Comparative in vitro antimicrobial activity of carumonam (Ro 17-2301) and its influence on the activity of other antibiotics

I. M. Hoepelman; G. Steyger; M. Rozenberg-Arska; J. Verhoef

doi:10.1159/000238482

Comparative in vitro antimicrobial activity of carumonam (Ro 17-2301) and its influence on the activity of other antibiotics

I. M. Hoepelman^*, G. Steyger, M. Rozenberg-Arska, J. Verhoef

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The antimicrobial activity of carumonam (Ro 17-2301) was compared with that of 20 antibiotics against 338 clinical isolates. Carumonam did not possess activity against gram-positive cocci, MIC₉₀of carumonam were ≤0.5 mg/1 for Enterobacteria- ceae, except for Citrobacter (≤8 mg/1) and ≤32 mg/1 for nonfermenters. It was slightly more active than aztreonam against gentamicin-resistant bacilli (MIC90 ≤64 vs≥256). Combinations of carumonam with antibiotics with activity against gram-positive microorganisms were indifferent.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Chemotherapy
Volume	33
Issue number	2
DOIs	https://doi.org/10.1159/000238482
Publication status	Published - 1 Jan 1987

Keywords

Carumonam
Gentamicin-resistant bacilli
In vitro activity
Ro 17-2301
Synergism

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title = "Comparative in vitro antimicrobial activity of carumonam (Ro 17-2301) and its influence on the activity of other antibiotics",

abstract = "The antimicrobial activity of carumonam (Ro 17-2301) was compared with that of 20 antibiotics against 338 clinical isolates. Carumonam did not possess activity against gram-positive cocci, MIC90of carumonam were ≤0.5 mg/1 for Enterobacteria- ceae, except for Citrobacter (≤8 mg/1) and ≤32 mg/1 for nonfermenters. It was slightly more active than aztreonam against gentamicin-resistant bacilli (MIC90 ≤64 vs≥256). Combinations of carumonam with antibiotics with activity against gram-positive microorganisms were indifferent.",

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AU - Steyger, G.

AU - Rozenberg-Arska, M.

AU - Verhoef, J.

PY - 1987/1/1

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N2 - The antimicrobial activity of carumonam (Ro 17-2301) was compared with that of 20 antibiotics against 338 clinical isolates. Carumonam did not possess activity against gram-positive cocci, MIC90of carumonam were ≤0.5 mg/1 for Enterobacteria- ceae, except for Citrobacter (≤8 mg/1) and ≤32 mg/1 for nonfermenters. It was slightly more active than aztreonam against gentamicin-resistant bacilli (MIC90 ≤64 vs≥256). Combinations of carumonam with antibiotics with activity against gram-positive microorganisms were indifferent.

AB - The antimicrobial activity of carumonam (Ro 17-2301) was compared with that of 20 antibiotics against 338 clinical isolates. Carumonam did not possess activity against gram-positive cocci, MIC90of carumonam were ≤0.5 mg/1 for Enterobacteria- ceae, except for Citrobacter (≤8 mg/1) and ≤32 mg/1 for nonfermenters. It was slightly more active than aztreonam against gentamicin-resistant bacilli (MIC90 ≤64 vs≥256). Combinations of carumonam with antibiotics with activity against gram-positive microorganisms were indifferent.

KW - Carumonam

KW - Gentamicin-resistant bacilli

KW - In vitro activity

KW - Ro 17-2301

KW - Synergism

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JO - Chemotherapy

JF - Chemotherapy

IS - 2

ER -

Comparative in vitro antimicrobial activity of carumonam (Ro 17-2301) and its influence on the activity of other antibiotics

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