Comparative in vitro antibacterial activity of the new carbapenem meropenem (SM-7338)

M. R. Visser; I. M. Hoepelman; H. Beumer; M. Rozenberg-Arska; J. Verhoef

doi:10.1007/BF01975170

Comparative in vitro antibacterial activity of the new carbapenem meropenem (SM-7338)

M. R. Visser^*, I. M. Hoepelman, H. Beumer, M. Rozenberg-Arska, J. Verhoef

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

The in vitro antimicrobial activity of the new carbapenem meropenem (SM-7338) was determined by an agar dilution method in comparison with imipenem, ticarcillin/calvulanic acid, ceftazidime and the fourth-generation cephalosporin cefepime (BMY 28142). Meropenem showed superior activity against Enterobacteriaceae (MIC90≤0.06 mg/l) and against non-fermentative gram-negative rods, with the exception of Xanthomonas maltophilia. Meropenem had excellent activity against beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae, and against the Bacteroides fragilis group. Imipenem was slightly more active then meropenem against gram-positive cocci especially Enterococcus faecalis.

Original language	English
Pages (from-to)	1061-1064
Number of pages	4
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	8
Issue number	12
DOIs	https://doi.org/10.1007/BF01975170
Publication status	Published - 1 Dec 1989

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abstract = "The in vitro antimicrobial activity of the new carbapenem meropenem (SM-7338) was determined by an agar dilution method in comparison with imipenem, ticarcillin/calvulanic acid, ceftazidime and the fourth-generation cephalosporin cefepime (BMY 28142). Meropenem showed superior activity against Enterobacteriaceae (MIC90≤0.06 mg/l) and against non-fermentative gram-negative rods, with the exception of Xanthomonas maltophilia. Meropenem had excellent activity against beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae, and against the Bacteroides fragilis group. Imipenem was slightly more active then meropenem against gram-positive cocci especially Enterococcus faecalis.",

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AU - Visser, M. R.

AU - Hoepelman, I. M.

AU - Beumer, H.

AU - Rozenberg-Arska, M.

AU - Verhoef, J.

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AB - The in vitro antimicrobial activity of the new carbapenem meropenem (SM-7338) was determined by an agar dilution method in comparison with imipenem, ticarcillin/calvulanic acid, ceftazidime and the fourth-generation cephalosporin cefepime (BMY 28142). Meropenem showed superior activity against Enterobacteriaceae (MIC90≤0.06 mg/l) and against non-fermentative gram-negative rods, with the exception of Xanthomonas maltophilia. Meropenem had excellent activity against beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae, and against the Bacteroides fragilis group. Imipenem was slightly more active then meropenem against gram-positive cocci especially Enterococcus faecalis.

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Comparative in vitro antibacterial activity of the new carbapenem meropenem (SM-7338)

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