Combined therapy for thyroid squamous cell carcinoma

Filip Yves F L De Vos; Aniel Sewnaik; J Hans W de Wilt; Ernst J Smid; Michael A den Bakker; Esther van Meerten

doi:10.1002/hed.21484

Combined therapy for thyroid squamous cell carcinoma

Filip Yves F L De Vos^*, Aniel Sewnaik, J Hans W de Wilt, Ernst J Smid, Michael A den Bakker, Esther van Meerten

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND.: Squamous carcinoma of the thyroid is a rare aggressive disease, resulting in poor prognosis. METHODS AND RESULTS.: We combined cisplatin with paclitaxel on a weekly basis as induction therapy, achieving a high cumulative dose, in a patient with squamous cell tumor of the thyroid with arterial encasement. After surgery, pathologic examination confirmed a complete resection of the primary tumor with clear margins, revealing a successful induction treatment with chemotherapy. CONCLUSIONS.: Our patient now has a recurrence-free survival of >20 months, longer than the mean survival described in the literature.

Original language	English
Pages (from-to)	131-134
Number of pages	4
Journal	Head and Neck
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/hed.21484
Publication status	Published - Jan 2012

Keywords

Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Squamous Cell
Cisplatin
Combined Modality Therapy
Female
Humans
Induction Chemotherapy
Middle Aged
Paclitaxel
Thyroid Neoplasms

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title = "Combined therapy for thyroid squamous cell carcinoma",

abstract = "BACKGROUND.: Squamous carcinoma of the thyroid is a rare aggressive disease, resulting in poor prognosis. METHODS AND RESULTS.: We combined cisplatin with paclitaxel on a weekly basis as induction therapy, achieving a high cumulative dose, in a patient with squamous cell tumor of the thyroid with arterial encasement. After surgery, pathologic examination confirmed a complete resection of the primary tumor with clear margins, revealing a successful induction treatment with chemotherapy. CONCLUSIONS.: Our patient now has a recurrence-free survival of >20 months, longer than the mean survival described in the literature.",

keywords = "Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Cisplatin, Combined Modality Therapy, Female, Humans, Induction Chemotherapy, Middle Aged, Paclitaxel, Thyroid Neoplasms",

author = "{De Vos}, {Filip Yves F L} and Aniel Sewnaik and {de Wilt}, {J Hans W} and Smid, {Ernst J} and {den Bakker}, {Michael A} and {van Meerten}, Esther",

note = "Copyright {\textcopyright} 2010 Wiley Periodicals, Inc.",

year = "2012",

month = jan,

doi = "10.1002/hed.21484",

language = "English",

volume = "34",

pages = "131--134",

journal = "Head and Neck",

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T1 - Combined therapy for thyroid squamous cell carcinoma

AU - De Vos, Filip Yves F L

AU - Sewnaik, Aniel

AU - de Wilt, J Hans W

AU - Smid, Ernst J

AU - den Bakker, Michael A

AU - van Meerten, Esther

PY - 2012/1

Y1 - 2012/1

N2 - BACKGROUND.: Squamous carcinoma of the thyroid is a rare aggressive disease, resulting in poor prognosis. METHODS AND RESULTS.: We combined cisplatin with paclitaxel on a weekly basis as induction therapy, achieving a high cumulative dose, in a patient with squamous cell tumor of the thyroid with arterial encasement. After surgery, pathologic examination confirmed a complete resection of the primary tumor with clear margins, revealing a successful induction treatment with chemotherapy. CONCLUSIONS.: Our patient now has a recurrence-free survival of >20 months, longer than the mean survival described in the literature.

AB - BACKGROUND.: Squamous carcinoma of the thyroid is a rare aggressive disease, resulting in poor prognosis. METHODS AND RESULTS.: We combined cisplatin with paclitaxel on a weekly basis as induction therapy, achieving a high cumulative dose, in a patient with squamous cell tumor of the thyroid with arterial encasement. After surgery, pathologic examination confirmed a complete resection of the primary tumor with clear margins, revealing a successful induction treatment with chemotherapy. CONCLUSIONS.: Our patient now has a recurrence-free survival of >20 months, longer than the mean survival described in the literature.

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Carcinoma, Squamous Cell

KW - Cisplatin

KW - Combined Modality Therapy

KW - Female

KW - Humans

KW - Induction Chemotherapy

KW - Middle Aged

KW - Paclitaxel

KW - Thyroid Neoplasms

U2 - 10.1002/hed.21484

DO - 10.1002/hed.21484

M3 - Article

C2 - 20652981

SN - 1043-3074

VL - 34

SP - 131

EP - 134

JO - Head and Neck

JF - Head and Neck

IS - 1

ER -

Combined therapy for thyroid squamous cell carcinoma

Abstract

Keywords

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