Colorectal cancer stem cells: regulation of the phenotype and implications for therapy resistance

BL Emmink

Colorectal cancer stem cells: regulation of the phenotype and implications for therapy resistance

BL Emmink

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

In this thesis different aspects of cancer stem cells in colorectal cancer are discribed. We focus on the therapy resistance of cancer stem cells and the effect that reactive oxygen species and hypoxia have on the cancer stem cell phenotype. For this purpose a novel culture method to propagate cancer stem cells form resected tumor specimens was used

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Borel Rinkes, Inne, Primary supervisor Kranenburg, Onno, Co-supervisor Jimenez, C.R., Co-supervisor, External person
Award date	6 Nov 2014
Publisher	Utrecht University
Print ISBNs	978-94-6108-812-3
Publication status	Published - 6 Nov 2014

Keywords

colorectal
cancer stem cells
reactive oxygen species
therapy resistance
phenotype

Cite this

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title = "Colorectal cancer stem cells: regulation of the phenotype and implications for therapy resistance",

abstract = "In this thesis different aspects of cancer stem cells in colorectal cancer are discribed. We focus on the therapy resistance of cancer stem cells and the effect that reactive oxygen species and hypoxia have on the cancer stem cell phenotype. For this purpose a novel culture method to propagate cancer stem cells form resected tumor specimens was used",

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year = "2014",

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TY - THES

T1 - Colorectal cancer stem cells

T2 - regulation of the phenotype and implications for therapy resistance

AU - Emmink, BL

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N2 - In this thesis different aspects of cancer stem cells in colorectal cancer are discribed. We focus on the therapy resistance of cancer stem cells and the effect that reactive oxygen species and hypoxia have on the cancer stem cell phenotype. For this purpose a novel culture method to propagate cancer stem cells form resected tumor specimens was used

AB - In this thesis different aspects of cancer stem cells in colorectal cancer are discribed. We focus on the therapy resistance of cancer stem cells and the effect that reactive oxygen species and hypoxia have on the cancer stem cell phenotype. For this purpose a novel culture method to propagate cancer stem cells form resected tumor specimens was used

KW - colorectal

KW - cancer stem cells

KW - reactive oxygen species

KW - therapy resistance

KW - phenotype

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-94-6108-812-3

PB - Utrecht University

ER -

Colorectal cancer stem cells: regulation of the phenotype and implications for therapy resistance

Abstract

Keywords

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