Colonic Crypts: Safe Haven from Microbial Products

HJG Snippert

doi:10.1016/j.cell.2016.06.003

Colonic Crypts: Safe Haven from Microbial Products

HJG Snippert

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The notion that the colon’s deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.

Original language	English
Pages (from-to)	1564–1566
Journal	Cell
Volume	165
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2016.06.003
Publication status	Published - 2016

Access to Document

10.1016/j.cell.2016.06.003

22-mainFinal published version, 403 KBLicence: Taverne

Cite this

@article{887e59230d344f0d94d85369934299cc,

title = "Colonic Crypts: Safe Haven from Microbial Products",

abstract = "The notion that the colon{\textquoteright}s deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture. ",

author = "HJG Snippert",

year = "2016",

doi = "10.1016/j.cell.2016.06.003",

language = "English",

volume = "165",

pages = "1564–1566",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Colonic Crypts: Safe Haven from Microbial Products

AU - Snippert, HJG

PY - 2016

Y1 - 2016

N2 - The notion that the colon’s deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.

AB - The notion that the colon’s deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.

U2 - 10.1016/j.cell.2016.06.003

DO - 10.1016/j.cell.2016.06.003

M3 - Article

C2 - 27315471

SN - 0092-8674

VL - 165

SP - 1564

EP - 1566

JO - Cell

JF - Cell

IS - 7

ER -

Colonic Crypts: Safe Haven from Microbial Products

Abstract

Access to Document

Fingerprint

Cite this