Colonic Crypts: Safe Haven from Microbial Products

HJG Snippert

doi:10.1016/j.cell.2016.06.003

Colonic Crypts: Safe Haven from Microbial Products

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The notion that the colon’s deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.

Original language	English
Pages (from-to)	1564–1566
Journal	Cell
Volume	165
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2016.06.003
Publication status	Published - 2016

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10.1016/j.cell.2016.06.003

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title = "Colonic Crypts: Safe Haven from Microbial Products",

abstract = "The notion that the colon{\textquoteright}s deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.",

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AB - The notion that the colon’s deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.

U2 - 10.1016/j.cell.2016.06.003

DO - 10.1016/j.cell.2016.06.003

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SN - 0092-8674

VL - 165

SP - 1564

EP - 1566

JO - Cell

JF - Cell

IS - 7

ER -

Colonic Crypts: Safe Haven from Microbial Products

Abstract

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