Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors

C. M.T. Schilder; C. Seynaeve; S. C. Linn; W. Boogerd; L. V.A.M. Beex; C. M. Gundy; J. W.R. Nortier; C. J.H. van de Velde; F. S.A.M. van Dam; S. B. Schagen

doi:10.1016/j.critrevonc.2009.11.001

Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors

C. M.T. Schilder, C. Seynaeve, S. C. Linn, W. Boogerd, L. V.A.M. Beex, C. M. Gundy, J. W.R. Nortier, C. J.H. van de Velde, F. S.A.M. van Dam, S. B. Schagen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

Purpose: This study aimed to identify medical and psychological predictors for cognitive performance of breast cancer (BC) patients before the start of adjuvant systemic treatment and to compare cognitive performance between BC patients and healthy controls adjusting for medical and psychological variables. Material: 205 postmenopausal BC patients underwent pre-treatment neuropsychological tests and provided medical and psychological data. 124 healthy controls underwent the same assessment. Results: 'Treatment for diabetes mellitus' and/or 'hypertension', 'less hours spent on cognitively stimulating activities', 'fewer days since surgery' and 'more reproductive years' were associated with worse cognitive performance in the BC patients, independent of age and IQ. Cognitive differences between BC patients and healthy controls could partly be explained by the evaluated variables. Conclusion: The results stress the need for adjustment for pre-treatment cognitive differences between study groups, and also indicate that further research into pre-treatment cognitive dysfunction is warranted.

Original language	English
Pages (from-to)	133-141
Number of pages	9
Journal	Critical Reviews in Oncology/Hematology
Volume	76
Issue number	2
DOIs	https://doi.org/10.1016/j.critrevonc.2009.11.001
Publication status	Published - Nov 2010
Externally published	Yes

Keywords

Adjuvant systemic treatment
Breast cancer
Cognitive function
Neuropsychological testing
Postmenopausal
Psychological function

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10.1016/j.critrevonc.2009.11.001

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Schilder, C. M. T., Seynaeve, C., Linn, S. C., Boogerd, W., Beex, L. V. A. M., Gundy, C. M., Nortier, J. W. R., van de Velde, C. J. H., van Dam, F. S. A. M., & Schagen, S. B. (2010). Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors. Critical Reviews in Oncology/Hematology, 76(2), 133-141. https://doi.org/10.1016/j.critrevonc.2009.11.001

@article{50a13ca5ac8c4338a516bea3d0d18169,

title = "Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors",

abstract = "Purpose: This study aimed to identify medical and psychological predictors for cognitive performance of breast cancer (BC) patients before the start of adjuvant systemic treatment and to compare cognitive performance between BC patients and healthy controls adjusting for medical and psychological variables. Material: 205 postmenopausal BC patients underwent pre-treatment neuropsychological tests and provided medical and psychological data. 124 healthy controls underwent the same assessment. Results: 'Treatment for diabetes mellitus' and/or 'hypertension', 'less hours spent on cognitively stimulating activities', 'fewer days since surgery' and 'more reproductive years' were associated with worse cognitive performance in the BC patients, independent of age and IQ. Cognitive differences between BC patients and healthy controls could partly be explained by the evaluated variables. Conclusion: The results stress the need for adjustment for pre-treatment cognitive differences between study groups, and also indicate that further research into pre-treatment cognitive dysfunction is warranted.",

keywords = "Adjuvant systemic treatment, Breast cancer, Cognitive function, Neuropsychological testing, Postmenopausal, Psychological function",

author = "Schilder, {C. M.T.} and C. Seynaeve and Linn, {S. C.} and W. Boogerd and Beex, {L. V.A.M.} and Gundy, {C. M.} and Nortier, {J. W.R.} and {van de Velde}, {C. J.H.} and {van Dam}, {F. S.A.M.} and Schagen, {S. B.}",

note = "Funding Information: This original work was supported by an independent research grant from Pfizer. Schilder CMT, the first author, receives salary out of this independent research grant. Seynaeve C, Linn SC, Boogerd W, Beex LVAM, Gundy CM, Nortier JWR, van de Velde CJH, van Dam FSAM, and Schagen SB have no conflict of interests. ",

year = "2010",

month = nov,

doi = "10.1016/j.critrevonc.2009.11.001",

language = "English",

volume = "76",

pages = "133--141",

journal = "Critical Reviews in Oncology/Hematology",

issn = "1040-8428",

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number = "2",

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Schilder, CMT, Seynaeve, C, Linn, SC, Boogerd, W, Beex, LVAM, Gundy, CM, Nortier, JWR, van de Velde, CJH, van Dam, FSAM & Schagen, SB 2010, 'Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors', Critical Reviews in Oncology/Hematology, vol. 76, no. 2, pp. 133-141. https://doi.org/10.1016/j.critrevonc.2009.11.001

TY - JOUR

T1 - Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors

AU - Schilder, C. M.T.

AU - Seynaeve, C.

AU - Linn, S. C.

AU - Boogerd, W.

AU - Beex, L. V.A.M.

AU - Gundy, C. M.

AU - Nortier, J. W.R.

AU - van de Velde, C. J.H.

AU - van Dam, F. S.A.M.

AU - Schagen, S. B.

N1 - Funding Information: This original work was supported by an independent research grant from Pfizer. Schilder CMT, the first author, receives salary out of this independent research grant. Seynaeve C, Linn SC, Boogerd W, Beex LVAM, Gundy CM, Nortier JWR, van de Velde CJH, van Dam FSAM, and Schagen SB have no conflict of interests.

PY - 2010/11

Y1 - 2010/11

N2 - Purpose: This study aimed to identify medical and psychological predictors for cognitive performance of breast cancer (BC) patients before the start of adjuvant systemic treatment and to compare cognitive performance between BC patients and healthy controls adjusting for medical and psychological variables. Material: 205 postmenopausal BC patients underwent pre-treatment neuropsychological tests and provided medical and psychological data. 124 healthy controls underwent the same assessment. Results: 'Treatment for diabetes mellitus' and/or 'hypertension', 'less hours spent on cognitively stimulating activities', 'fewer days since surgery' and 'more reproductive years' were associated with worse cognitive performance in the BC patients, independent of age and IQ. Cognitive differences between BC patients and healthy controls could partly be explained by the evaluated variables. Conclusion: The results stress the need for adjustment for pre-treatment cognitive differences between study groups, and also indicate that further research into pre-treatment cognitive dysfunction is warranted.

AB - Purpose: This study aimed to identify medical and psychological predictors for cognitive performance of breast cancer (BC) patients before the start of adjuvant systemic treatment and to compare cognitive performance between BC patients and healthy controls adjusting for medical and psychological variables. Material: 205 postmenopausal BC patients underwent pre-treatment neuropsychological tests and provided medical and psychological data. 124 healthy controls underwent the same assessment. Results: 'Treatment for diabetes mellitus' and/or 'hypertension', 'less hours spent on cognitively stimulating activities', 'fewer days since surgery' and 'more reproductive years' were associated with worse cognitive performance in the BC patients, independent of age and IQ. Cognitive differences between BC patients and healthy controls could partly be explained by the evaluated variables. Conclusion: The results stress the need for adjustment for pre-treatment cognitive differences between study groups, and also indicate that further research into pre-treatment cognitive dysfunction is warranted.

KW - Adjuvant systemic treatment

KW - Breast cancer

KW - Cognitive function

KW - Neuropsychological testing

KW - Postmenopausal

KW - Psychological function

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DO - 10.1016/j.critrevonc.2009.11.001

M3 - Review article

C2 - 20036141

AN - SCOPUS:77957904566

SN - 1040-8428

VL - 76

SP - 133

EP - 141

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

IS - 2

ER -

Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors

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Keywords

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