Cognitive decline in elderly bipolar disorder patients: a follow-up study

Sigfried Ntm Schouws; Max L Stek; Hannie C Comijs; Annemiek Dols; Aartjan Tf Beekman

doi:10.1111/bdi.12000

Cognitive decline in elderly bipolar disorder patients: a follow-up study

Sigfried Ntm Schouws, Max L Stek, Hannie C Comijs, Annemiek Dols, Aartjan Tf Beekman

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: Older individuals with bipolar disorder may exhibit greater cognitive decline over time compared to mentally healthy elderly individuals. We aimed to investigate neurocognitive performance in bipolar disorder over a period of two years.

METHODS: A comprehensive neuropsychological test battery was applied at baseline and two years later to 65 euthymic elderly outpatients with bipolar disorder (mean age = 68.35, range: 60-90 years) and to a demographically comparable sample of 42 healthy elderly controls. A general linear model was used to measure changes over time for the two groups. The impact of baseline illness characteristics on intra-individual change in neurocognitive performance within the bipolar group was studied by using logistic regression analysis.

RESULTS: At baseline and at follow up, bipolar disorder patients performed worse on all neurocognitive measures compared to the healthy elderly group. However, there was no significant group-by-time interaction between the bipolar disorder patients and the comparison group.

CONCLUSIONS: Although older bipolar disorder patients have worse cognitive function than normal controls, they did not have greater cognitive decline over a period of two years.

Original language	English
Pages (from-to)	749-55
Number of pages	7
Journal	Bipolar Disorders
Volume	14
Issue number	7
DOIs	https://doi.org/10.1111/bdi.12000
Publication status	Published - Nov 2012
Externally published	Yes

Keywords

Aged
Aged, 80 and over
Analysis of Variance
Antimanic Agents/therapeutic use
Bipolar Disorder/complications
Cognition Disorders/diagnosis
Female
Follow-Up Studies
Geriatrics
Humans
Male
Middle Aged
Neuropsychological Tests
Psychiatric Status Rating Scales

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10.1111/bdi.12000

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title = "Cognitive decline in elderly bipolar disorder patients: a follow-up study",

abstract = "OBJECTIVE: Older individuals with bipolar disorder may exhibit greater cognitive decline over time compared to mentally healthy elderly individuals. We aimed to investigate neurocognitive performance in bipolar disorder over a period of two years.METHODS: A comprehensive neuropsychological test battery was applied at baseline and two years later to 65 euthymic elderly outpatients with bipolar disorder (mean age = 68.35, range: 60-90 years) and to a demographically comparable sample of 42 healthy elderly controls. A general linear model was used to measure changes over time for the two groups. The impact of baseline illness characteristics on intra-individual change in neurocognitive performance within the bipolar group was studied by using logistic regression analysis.RESULTS: At baseline and at follow up, bipolar disorder patients performed worse on all neurocognitive measures compared to the healthy elderly group. However, there was no significant group-by-time interaction between the bipolar disorder patients and the comparison group.CONCLUSIONS: Although older bipolar disorder patients have worse cognitive function than normal controls, they did not have greater cognitive decline over a period of two years.",

keywords = "Aged, Aged, 80 and over, Analysis of Variance, Antimanic Agents/therapeutic use, Bipolar Disorder/complications, Cognition Disorders/diagnosis, Female, Follow-Up Studies, Geriatrics, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales",

author = "Schouws, {Sigfried Ntm} and Stek, {Max L} and Comijs, {Hannie C} and Annemiek Dols and Beekman, {Aartjan Tf}",

note = "{\textcopyright} 2012 John Wiley and Sons A/S.",

year = "2012",

month = nov,

doi = "10.1111/bdi.12000",

language = "English",

volume = "14",

pages = "749--55",

journal = "Bipolar Disorders",

issn = "1398-5647",

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TY - JOUR

T1 - Cognitive decline in elderly bipolar disorder patients

T2 - a follow-up study

AU - Schouws, Sigfried Ntm

AU - Stek, Max L

AU - Comijs, Hannie C

AU - Dols, Annemiek

AU - Beekman, Aartjan Tf

PY - 2012/11

Y1 - 2012/11

N2 - OBJECTIVE: Older individuals with bipolar disorder may exhibit greater cognitive decline over time compared to mentally healthy elderly individuals. We aimed to investigate neurocognitive performance in bipolar disorder over a period of two years.METHODS: A comprehensive neuropsychological test battery was applied at baseline and two years later to 65 euthymic elderly outpatients with bipolar disorder (mean age = 68.35, range: 60-90 years) and to a demographically comparable sample of 42 healthy elderly controls. A general linear model was used to measure changes over time for the two groups. The impact of baseline illness characteristics on intra-individual change in neurocognitive performance within the bipolar group was studied by using logistic regression analysis.RESULTS: At baseline and at follow up, bipolar disorder patients performed worse on all neurocognitive measures compared to the healthy elderly group. However, there was no significant group-by-time interaction between the bipolar disorder patients and the comparison group.CONCLUSIONS: Although older bipolar disorder patients have worse cognitive function than normal controls, they did not have greater cognitive decline over a period of two years.

AB - OBJECTIVE: Older individuals with bipolar disorder may exhibit greater cognitive decline over time compared to mentally healthy elderly individuals. We aimed to investigate neurocognitive performance in bipolar disorder over a period of two years.METHODS: A comprehensive neuropsychological test battery was applied at baseline and two years later to 65 euthymic elderly outpatients with bipolar disorder (mean age = 68.35, range: 60-90 years) and to a demographically comparable sample of 42 healthy elderly controls. A general linear model was used to measure changes over time for the two groups. The impact of baseline illness characteristics on intra-individual change in neurocognitive performance within the bipolar group was studied by using logistic regression analysis.RESULTS: At baseline and at follow up, bipolar disorder patients performed worse on all neurocognitive measures compared to the healthy elderly group. However, there was no significant group-by-time interaction between the bipolar disorder patients and the comparison group.CONCLUSIONS: Although older bipolar disorder patients have worse cognitive function than normal controls, they did not have greater cognitive decline over a period of two years.

KW - Aged

KW - Aged, 80 and over

KW - Analysis of Variance

KW - Antimanic Agents/therapeutic use

KW - Bipolar Disorder/complications

KW - Cognition Disorders/diagnosis

KW - Female

KW - Follow-Up Studies

KW - Geriatrics

KW - Humans

KW - Male

KW - Middle Aged

KW - Neuropsychological Tests

KW - Psychiatric Status Rating Scales

U2 - 10.1111/bdi.12000

DO - 10.1111/bdi.12000

M3 - Article

C2 - 22998105

SN - 1398-5647

VL - 14

SP - 749

EP - 755

JO - Bipolar Disorders

JF - Bipolar Disorders

IS - 7

ER -

Cognitive decline in elderly bipolar disorder patients: a follow-up study

Abstract

Keywords

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