Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Christina Bamia; Pagona Lagiou; Mazda Jenab; Antonia Trichopoulou; Veronika Fedirko; Krasimira Aleksandrova; Tobias Pischon; Kim Overvad; Anja Olsen; Anne Tjonneland; Marie-Christine Boutron-Ruault; Guy Fagherazzi; Antoine Racine; Tilman Kuhn; Heiner Boeing; Anna Floegel; Vasiliki Benetou; Domenico Palli; Sara Grioni; Salvatore Panico; Rosario Tumino; Paolo Vineis; H. B. (as) Bueno-de-Mesquita; Vincent K. Dik; Nirmala Bhoo Pathy; Cuno S.P.M. Uiterwaal; Elisabete Weiderpass; Eiliv Lund; J. Ramon Quiros; Raul Zamora-Ros; Esther Molina-Montes; Maria-Dolores Chirlaque; Eva Ardanaz; Miren Dorronsoro; Bjoern Lindkvist; Peter Wallstroem; Lena Maria Nilsson; Malin Sund; Kay-Tee Khaw; Nick Wareham; Kathryn E. Bradbury; Ruth C. Travis; Pietro Ferrari; Talita Duarte-Salles; Magdalena Stepien; Marc Gunter; Neil Murphy; Elio Riboli; Dimitrios Trichopoulos

doi:10.1002/ijc.29214

Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Christina Bamia^*, Pagona Lagiou, Mazda Jenab, Antonia Trichopoulou, Veronika Fedirko, Krasimira Aleksandrova, Tobias Pischon, Kim Overvad, Anja Olsen, Anne Tjonneland, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Antoine Racine, Tilman Kuhn, Heiner Boeing, Anna Floegel, Vasiliki Benetou, Domenico Palli, Sara Grioni, Salvatore PanicoRosario Tumino, Paolo Vineis, H. B. (as) Bueno-de-Mesquita, Vincent K. Dik, Nirmala Bhoo Pathy, Cuno S.P.M. Uiterwaal, Elisabete Weiderpass, Eiliv Lund, J. Ramon Quiros, Raul Zamora-Ros, Esther Molina-Montes, Maria-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Bjoern Lindkvist, Peter Wallstroem, Lena Maria Nilsson, Malin Sund, Kay-Tee Khaw, Nick Wareham, Kathryn E. Bradbury, Ruth C. Travis, Pietro Ferrari, Talita Duarte-Salles, Magdalena Stepien, Marc Gunter, Neil Murphy, Elio Riboli, Dimitrios Trichopoulos

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend

Original language	English
Pages (from-to)	1899-1908
Number of pages	10
Journal	International Journal of Cancer
Volume	136
Issue number	8
DOIs	https://doi.org/10.1002/ijc.29214
Publication status	Published - 15 Apr 2015

Keywords

hepatocellular carcinoma
liver cancer
coffee
tea
EPIC
CHRONIC LIVER-DISEASE
RISK-FACTORS
GREEN TEA
CANCER INCIDENCE
CONSUMPTION
JAPAN
DRINKING
ASSOCIATION
EPIDEMIOLOGY
METAANALYSIS

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Bamia, C., Lagiou, P., Jenab, M., Trichopoulou, A., Fedirko, V., Aleksandrova, K., Pischon, T., Overvad, K., Olsen, A., Tjonneland, A., Boutron-Ruault, M.-C., Fagherazzi, G., Racine, A., Kuhn, T., Boeing, H., Floegel, A., Benetou, V., Palli, D., Grioni, S., ... Trichopoulos, D. (2015). Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study. International Journal of Cancer, 136(8), 1899-1908. https://doi.org/10.1002/ijc.29214

@article{6265bede13d2432b98921fbcccdf1024,

title = "Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study",

abstract = "Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend",

keywords = "hepatocellular carcinoma, liver cancer, coffee, tea, EPIC, CHRONIC LIVER-DISEASE, RISK-FACTORS, GREEN TEA, CANCER INCIDENCE, CONSUMPTION, JAPAN, DRINKING, ASSOCIATION, EPIDEMIOLOGY, METAANALYSIS",

author = "Christina Bamia and Pagona Lagiou and Mazda Jenab and Antonia Trichopoulou and Veronika Fedirko and Krasimira Aleksandrova and Tobias Pischon and Kim Overvad and Anja Olsen and Anne Tjonneland and Marie-Christine Boutron-Ruault and Guy Fagherazzi and Antoine Racine and Tilman Kuhn and Heiner Boeing and Anna Floegel and Vasiliki Benetou and Domenico Palli and Sara Grioni and Salvatore Panico and Rosario Tumino and Paolo Vineis and Bueno-de-Mesquita, {H. B. (as)} and Dik, {Vincent K.} and {Bhoo Pathy}, Nirmala and Uiterwaal, {Cuno S.P.M.} and Elisabete Weiderpass and Eiliv Lund and Quiros, {J. Ramon} and Raul Zamora-Ros and Esther Molina-Montes and Maria-Dolores Chirlaque and Eva Ardanaz and Miren Dorronsoro and Bjoern Lindkvist and Peter Wallstroem and Nilsson, {Lena Maria} and Malin Sund and Kay-Tee Khaw and Nick Wareham and Bradbury, {Kathryn E.} and Travis, {Ruth C.} and Pietro Ferrari and Talita Duarte-Salles and Magdalena Stepien and Marc Gunter and Neil Murphy and Elio Riboli and Dimitrios Trichopoulos",

year = "2015",

month = apr,

day = "15",

doi = "10.1002/ijc.29214",

language = "English",

volume = "136",

pages = "1899--1908",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley & Sons Inc.",

number = "8",

}

Bamia, C, Lagiou, P, Jenab, M, Trichopoulou, A, Fedirko, V, Aleksandrova, K, Pischon, T, Overvad, K, Olsen, A, Tjonneland, A, Boutron-Ruault, M-C, Fagherazzi, G, Racine, A, Kuhn, T, Boeing, H, Floegel, A, Benetou, V, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, HB, Dik, VK, Bhoo Pathy, N, Uiterwaal, CSPM, Weiderpass, E, Lund, E, Quiros, JR, Zamora-Ros, R, Molina-Montes, E, Chirlaque, M-D, Ardanaz, E, Dorronsoro, M, Lindkvist, B, Wallstroem, P, Nilsson, LM, Sund, M, Khaw, K-T, Wareham, N, Bradbury, KE, Travis, RC, Ferrari, P, Duarte-Salles, T, Stepien, M, Gunter, M, Murphy, N, Riboli, E & Trichopoulos, D 2015, 'Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study', International Journal of Cancer, vol. 136, no. 8, pp. 1899-1908. https://doi.org/10.1002/ijc.29214

TY - JOUR

T1 - Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population

T2 - Multicentre, prospective cohort study

AU - Bamia, Christina

AU - Lagiou, Pagona

AU - Jenab, Mazda

AU - Trichopoulou, Antonia

AU - Fedirko, Veronika

AU - Aleksandrova, Krasimira

AU - Pischon, Tobias

AU - Overvad, Kim

AU - Olsen, Anja

AU - Tjonneland, Anne

AU - Boutron-Ruault, Marie-Christine

AU - Fagherazzi, Guy

AU - Racine, Antoine

AU - Kuhn, Tilman

AU - Boeing, Heiner

AU - Floegel, Anna

AU - Benetou, Vasiliki

AU - Palli, Domenico

AU - Grioni, Sara

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Bueno-de-Mesquita, H. B. (as)

AU - Dik, Vincent K.

AU - Bhoo Pathy, Nirmala

AU - Uiterwaal, Cuno S.P.M.

AU - Weiderpass, Elisabete

AU - Lund, Eiliv

AU - Quiros, J. Ramon

AU - Zamora-Ros, Raul

AU - Molina-Montes, Esther

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Dorronsoro, Miren

AU - Lindkvist, Bjoern

AU - Wallstroem, Peter

AU - Nilsson, Lena Maria

AU - Sund, Malin

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Bradbury, Kathryn E.

AU - Travis, Ruth C.

AU - Ferrari, Pietro

AU - Duarte-Salles, Talita

AU - Stepien, Magdalena

AU - Gunter, Marc

AU - Murphy, Neil

AU - Riboli, Elio

AU - Trichopoulos, Dimitrios

PY - 2015/4/15

Y1 - 2015/4/15

N2 - Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend

AB - Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend

KW - hepatocellular carcinoma

KW - liver cancer

KW - coffee

KW - tea

KW - EPIC

KW - CHRONIC LIVER-DISEASE

KW - RISK-FACTORS

KW - GREEN TEA

KW - CANCER INCIDENCE

KW - CONSUMPTION

KW - JAPAN

KW - DRINKING

KW - ASSOCIATION

KW - EPIDEMIOLOGY

KW - METAANALYSIS

U2 - 10.1002/ijc.29214

DO - 10.1002/ijc.29214

M3 - Article

C2 - 25219573

SN - 0020-7136

VL - 136

SP - 1899

EP - 1908

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 8

ER -

Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Abstract

Keywords

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