Co-prevalence of extracranial carotid aneurysms differs between European intracranial aneurysm cohorts

Constance J.H.C.M. van Laarhoven, Vanessa E.C. Pourier, Antti E. Lindgren, Mervyn D.I. Vergouwen, Juha E. Jääskeläinen, Gabriël J.E. Rinkel, Dominique P.V. de Kleijn, Gert J. de Borst*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background and purpose Previously, we showed that co-prevalence of extracranial carotid artery aneurysms (ECAAs) in patients with intracranial aneurysms (IAs) was 2% in a Dutch cohort. In order to obtain more precise estimates and discover potential predictors of ECAA co-prevalence in the European population, we retrospectively compared differences and similarities of our Dutch cohort with a Finnish cohort using protocolled imaging of the cerebrovascular tree. Methods IA patients within the prospective database of the Kuopio University Hospital were eligible for this study (n = 1,118). Image analysis and hospital chart review were conducted. Results In total, 458 patients with complete carotid imaging conform protocol were analyzed. Twenty-four ECAAs in 21 patients were identified (4.6%, 95% CI 2.9–6.9), a higher co-prevalence than in the Dutch cohort (1.9%; 95% CI 1.0–3.3), prevalence odds ratio (POR) 2.45 (95% CI 1.19–5.03). In the Finnish cohort, 25% of all ECAAs were located around the carotid bifurcation, others in the internal carotid artery distally from the bifurcation. Independent predictors for ECAA co-prevalence were origin of country (POR 2.41, 95% CI 1.15–5.06) and male gender (POR 2.25, 95% CI 1.09–4.64). Conclusion The co-prevalence of ECAA in IA patients was twice as high in the Finnish compared to the Dutch IA cohort, with origin of country and male gender as independent predictors. Twenty-five percent of ECAAs would be missed, if the carotid bifurcation was not imaged. Therefore, we propose to always include imaging of the carotid bifurcation as the gold standard technique to identify ECAA in IA patients.

Original languageEnglish
Article numbere0228041
Pages (from-to)1-10
JournalPLoS ONE
Volume15
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Angiography, Digital Subtraction
  • Carotid Arteries/diagnostic imaging
  • Cohort Studies
  • Europe/epidemiology
  • Female
  • Humans
  • Intracranial Aneurysm/diagnostic imaging
  • Logistic Models
  • Male
  • Middle Aged
  • Prevalence

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