CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy

G. M.J. Ramakers; B. W.M.M. Peeters; J. M.H. Vossen; A. M.L. Coenen

doi:10.1016/0920-1211(91)90023-9

CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy

G. M.J. Ramakers
, B. W.M.M. Peeters^*
, J. M.H. Vossen
, A. M.L. Coenen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

Abstract

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 μl CNQX) showed that CNQX decreases the number of spike wave discharges in a dose-dependent way. Coinjection of CNQX (100 nmol/5μJ) and AMPA (0.1 pmol/5 μl), kainic acid (0.01 nmol/5 μl) or NMDA (50 pmol/5 μl) attenuated the CNQX response, indicating that CNQX acts on both non-NMDA and NMDA receptors. The observed effects appear to be specific manipulations of the epilepsy not mediated by behavioral changes.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Epilepsy Research
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0920-1211(91)90023-9
Publication status	Published - 1 Jan 1991

Keywords

Absence epilepsy
Antiepileptic drug
CNQX
NMDA receptors
Non-NMDA receptors
WAG/Rij rats

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10.1016/0920-1211(91)90023-9

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title = "CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy",

abstract = "The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 μl CNQX) showed that CNQX decreases the number of spike wave discharges in a dose-dependent way. Coinjection of CNQX (100 nmol/5μJ) and AMPA (0.1 pmol/5 μl), kainic acid (0.01 nmol/5 μl) or NMDA (50 pmol/5 μl) attenuated the CNQX response, indicating that CNQX acts on both non-NMDA and NMDA receptors. The observed effects appear to be specific manipulations of the epilepsy not mediated by behavioral changes.",

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year = "1991",

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AU - Ramakers, G. M.J.

AU - Peeters, B. W.M.M.

AU - Vossen, J. M.H.

AU - Coenen, A. M.L.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 μl CNQX) showed that CNQX decreases the number of spike wave discharges in a dose-dependent way. Coinjection of CNQX (100 nmol/5μJ) and AMPA (0.1 pmol/5 μl), kainic acid (0.01 nmol/5 μl) or NMDA (50 pmol/5 μl) attenuated the CNQX response, indicating that CNQX acts on both non-NMDA and NMDA receptors. The observed effects appear to be specific manipulations of the epilepsy not mediated by behavioral changes.

AB - The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 μl CNQX) showed that CNQX decreases the number of spike wave discharges in a dose-dependent way. Coinjection of CNQX (100 nmol/5μJ) and AMPA (0.1 pmol/5 μl), kainic acid (0.01 nmol/5 μl) or NMDA (50 pmol/5 μl) attenuated the CNQX response, indicating that CNQX acts on both non-NMDA and NMDA receptors. The observed effects appear to be specific manipulations of the epilepsy not mediated by behavioral changes.

KW - Absence epilepsy

KW - Antiepileptic drug

KW - CNQX

KW - NMDA receptors

KW - Non-NMDA receptors

KW - WAG/Rij rats

UR - https://www.scopus.com/pages/publications/0025868506

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SN - 0920-1211

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JO - Epilepsy Research

JF - Epilepsy Research

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ER -

CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy

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Keywords

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