Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome

Elisabeth A.  Cats; W. Ludo Van Der Pol; Anne P. Tio-Gillen; Frank P. Diekstra; Leonard H. Van Den Berg; Bart C. Jacobs

doi:10.1136/jnnp-2014-308118

Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome

Elisabeth A. Cats^*
, W. Ludo Van Der Pol
, Anne P. Tio-Gillen
, Frank P. Diekstra
, Leonard H. Van Den Berg
, Bart C. Jacobs

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Objective Multifocal motor neuropathy (MMN) and the Guillain-Barré syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive.

Methods We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA.

Results Exclusive use of either κ or λ light chains was found in 38 (90%) patients with MMN and 9 (39%) with GBS (p<0.001).

Conclusions Anti-GM1 IgM antibodies in most patients with MMN are produced by only a single or very limited number of B-cell clones, whereas in most patients with GBS, anti-GM1 IgM antibodies are most likely polyclonal.

Original language	English
Pages (from-to)	502-504
Number of pages	3
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	86
Issue number	5
DOIs	https://doi.org/10.1136/jnnp-2014-308118
Publication status	Published - 1 May 2015

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title = "Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barr{\'e} syndrome",

abstract = "Objective Multifocal motor neuropathy (MMN) and the Guillain-Barr{\'e} syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. Methods We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA. Results Exclusive use of either κ or λ light chains was found in 38 (90\%) patients with MMN and 9 (39\%) with GBS (p<0.001). Conclusions Anti-GM1 IgM antibodies in most patients with MMN are produced by only a single or very limited number of B-cell clones, whereas in most patients with GBS, anti-GM1 IgM antibodies are most likely polyclonal.",

author = "Cats, \{Elisabeth A.\} and \{Van Der Pol\}, \{W. Ludo\} and Tio-Gillen, \{Anne P.\} and Diekstra, \{Frank P.\} and \{Van Den Berg\}, \{Leonard H.\} and Jacobs, \{Bart C.\}",

year = "2015",

month = may,

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doi = "10.1136/jnnp-2014-308118",

language = "English",

volume = "86",

pages = "502--504",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

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publisher = "BMJ Publishing Group",

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TY - JOUR

T1 - Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome

AU - Cats, Elisabeth A.

AU - Van Der Pol, W. Ludo

AU - Tio-Gillen, Anne P.

AU - Diekstra, Frank P.

AU - Van Den Berg, Leonard H.

AU - Jacobs, Bart C.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objective Multifocal motor neuropathy (MMN) and the Guillain-Barré syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. Methods We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA. Results Exclusive use of either κ or λ light chains was found in 38 (90%) patients with MMN and 9 (39%) with GBS (p<0.001). Conclusions Anti-GM1 IgM antibodies in most patients with MMN are produced by only a single or very limited number of B-cell clones, whereas in most patients with GBS, anti-GM1 IgM antibodies are most likely polyclonal.

AB - Objective Multifocal motor neuropathy (MMN) and the Guillain-Barré syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. Methods We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA. Results Exclusive use of either κ or λ light chains was found in 38 (90%) patients with MMN and 9 (39%) with GBS (p<0.001). Conclusions Anti-GM1 IgM antibodies in most patients with MMN are produced by only a single or very limited number of B-cell clones, whereas in most patients with GBS, anti-GM1 IgM antibodies are most likely polyclonal.

UR - https://www.scopus.com/pages/publications/84927632161

U2 - 10.1136/jnnp-2014-308118

DO - 10.1136/jnnp-2014-308118

M3 - Article

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AN - SCOPUS:84927632161

SN - 0022-3050

VL - 86

SP - 502

EP - 504

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 5

ER -

Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome

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