Clinical trials for continuously monitored and updated AI systems

Wouter A.C. van Amsterdam; Michael Oberst; Jean Feng; Jenna Wiens; Shengpu Tang; Shalmali Joshi; Rajesh Ranganath; Mark Sendak; Uri Shalit; Julia E. Vogt; Brett Beaulieu-Jones; Muhammad Mamdani; David Kent; Patrick J. Heagerty; Thomas R. Fleming; Anna Goldenberg

doi:10.1038/s41591-026-04368-9

Clinical trials for continuously monitored and updated AI systems

Wouter A.C. van Amsterdam
, Michael Oberst
, Jean Feng
, Jenna Wiens
, Shengpu Tang
, Shalmali Joshi
, Rajesh Ranganath
, Mark Sendak
, Uri Shalit
, Julia E. Vogt
, Brett Beaulieu-Jones
, Muhammad Mamdani
, David Kent
, Patrick J. Heagerty
, Thomas R. Fleming
, Anna Goldenberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.

Original language	English
Pages (from-to)	1972-1974
Number of pages	3
Journal	Nature medicine
Volume	32
Issue number	6
Early online date	2026
DOIs	https://doi.org/10.1038/s41591-026-04368-9
Publication status	Published - Jun 2026

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van Amsterdam, W. A. C., Oberst, M., Feng, J., Wiens, J., Tang, S., Joshi, S., Ranganath, R., Sendak, M., Shalit, U., Vogt, J. E., Beaulieu-Jones, B., Mamdani, M., Kent, D., Heagerty, P. J., Fleming, T. R., & Goldenberg, A. (2026). Clinical trials for continuously monitored and updated AI systems. Nature medicine, 32(6), 1972-1974. https://doi.org/10.1038/s41591-026-04368-9

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author = "\{van Amsterdam\}, \{Wouter A.C.\} and Michael Oberst and Jean Feng and Jenna Wiens and Shengpu Tang and Shalmali Joshi and Rajesh Ranganath and Mark Sendak and Uri Shalit and Vogt, \{Julia E.\} and Brett Beaulieu-Jones and Muhammad Mamdani and David Kent and Heagerty, \{Patrick J.\} and Fleming, \{Thomas R.\} and Anna Goldenberg",

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doi = "10.1038/s41591-026-04368-9",

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T1 - Clinical trials for continuously monitored and updated AI systems

AU - van Amsterdam, Wouter A.C.

AU - Oberst, Michael

AU - Feng, Jean

AU - Wiens, Jenna

AU - Tang, Shengpu

AU - Joshi, Shalmali

AU - Ranganath, Rajesh

AU - Sendak, Mark

AU - Shalit, Uri

AU - Vogt, Julia E.

AU - Beaulieu-Jones, Brett

AU - Mamdani, Muhammad

AU - Kent, David

AU - Heagerty, Patrick J.

AU - Fleming, Thomas R.

AU - Goldenberg, Anna

PY - 2026/6

Y1 - 2026/6

N2 - As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.

AB - As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.

UR - https://www.scopus.com/pages/publications/105037926373

U2 - 10.1038/s41591-026-04368-9

DO - 10.1038/s41591-026-04368-9

M3 - Comment/Letter to the editor

C2 - 42050181

AN - SCOPUS:105037926373

SN - 1078-8956

VL - 32

SP - 1972

EP - 1974

JO - Nature medicine

JF - Nature medicine

IS - 6

ER -

Clinical trials for continuously monitored and updated AI systems

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