TY - JOUR
T1 - Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry
T2 - A prospective cohort study
AU - Habib, Gilbert
AU - Erba, Paola Anna
AU - Iung, Bernard
AU - Donal, Erwan
AU - Cosyns, Bernard
AU - Laroche, Cécile
AU - Popescu, Bogdan A.
AU - Prendergast, Bernard
AU - Tornos, Pilar
AU - Sadeghpour, Anita
AU - Oliver, Leopold
AU - Vaskelyte, Jolanta Justina
AU - Sow, Rouguiatou
AU - Axler, Olivier
AU - Maggioni, Aldo P.
AU - Lancellotti, Patrizio
AU - Gale, C. P.
AU - Beleslin, B.
AU - Budaj, A.
AU - Chioncel, O.
AU - Dagres, N.
AU - Danchin, N.
AU - Emberson, J.
AU - Erlinge, D.
AU - Glikson, M.
AU - Gray, A.
AU - Kayikcioglu, M.
AU - Nagy, V. K.
AU - Nedoshivin, A.
AU - Petronio, A. S.
AU - Roos-Hesselink, J.
AU - Wallentin, L.
AU - Zeymer, U.
AU - Andarala, M.
AU - Berle, C.
AU - Brunel-Lebecq, A.
AU - Schneider, M.
AU - Winter, M. P.
AU - Silva, L.
AU - Ali, M.
AU - Becker, M.
AU - Lee, S.
AU - Budde, R.
AU - Bekkers, S. C.
AU - Chamuleau, S.
AU - Cramer, M. J.
AU - Teske, A.
AU - Van der Spoel, T.
AU - Wind, A.
AU - Gunning, M.
N1 - Publisher Copyright:
© The Author(s) 2019.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2019/10/14
Y1 - 2019/10/14
N2 - Aims: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion: Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.
AB - Aims: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion: Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.
KW - Infective endocarditis
KW - Registry
KW - Valve disease
UR - http://www.scopus.com/inward/record.url?scp=85073182903&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehz620
DO - 10.1093/eurheartj/ehz620
M3 - Article
C2 - 31504413
AN - SCOPUS:85073182903
SN - 0195-668X
VL - 40
SP - 3222
EP - 3232
JO - European heart journal
JF - European heart journal
IS - 39
ER -