TY - JOUR
T1 - Clinical outcomes of the BioMime™ morph coronary stent system for long (30 to ≤56 mm length) coronary lesions
T2 - Three-year follow-up of the Morpheus Global Registry
AU - Agostoni, Pierfrancesco
AU - Van Kuijk, Jan-Peter
AU - Knaapen, Paul
AU - Fouladvand, Farhat
AU - Hudec, Martin
AU - Nicosia, Antonino
AU - Kervinen, Kari
AU - Tomasello, Salvatore Davide
AU - Singh, Ramesh Singh Arjan
AU - Vishwanathan, Girish N
AU - Merkely, Béla
AU - Liew, Houng Bang
AU - Al Faraidy, Khalid
AU - Corbett, Clive
AU - Dawood, Saleem
AU - Choudhury, Anirban
AU - Alhaddad, Imad Abdelhafiz
AU - Zaman, Azfar
AU - Kraaijeveld, Adriaan O
AU - Pepe, Martino
N1 - Publisher Copyright:
© 2025 Elsevier Inc.
PY - 2025/12
Y1 - 2025/12
N2 - BACKGROUND: Percutaneous coronary intervention (PCI) of long coronary artery lesions (CAL) presents a puzzle, often requiring multiple stents. As the arteries twist and narrow, this becomes even more challenging with issues like potential distal overexpansion and proximal under expansion, and edge dissections. The study aims to assess the safety and performance of BioMime™ Morph sirolimus-eluting stent (SES) in individuals with long CAL.METHODS: This prospective, single-arm, multi-center, observational, real-world registry, included 565 patients with long CAL (length 30 to ≤56 mm) in native coronary arteries (reference vessel diameters: 2.25 mm to 3.50 mm). Based on lesion length, patients were implanted with 30 mm, 40 mm, 50 mm, or 60 mm BioMime™ Morph SES. Primary endpoint was freedom of target lesion failure (TLF) at 6-month and up to 36-month.RESULTS: Over 65 % of patients had lesions requiring 50 mm and 60 mm stents. The follow-up length was up to 24-month for the whole cohort and up to 36-month only for 211 patients from seven selected centers. The freedom from TLF rate was 97.86 %, 97.26 %, 96.27 %, and 95.15 % at 6-, 12-, 24-, and 36-month follow-ups, respectively. The cumulative rates of major adverse cardiac events (MACE) were 2.74 % at 12-month, 3.73 % at 24-month and 4.85 % at 36-month. Additionally, the rates of ischemia-driven target lesion revascularization were 2.01 % at 12-month, 2.16 % at 24-month, and 3.88 % at 36-month. Lastly, stent thrombosis (ST) was reported in only 2 cases (0.97 %) at 36-month.CONCLUSION: The lower incidences of MACE and ST up to three-year follow-up indicate BioMime™ Morph SES is an effective and safe option for PCI in long CAL.
AB - BACKGROUND: Percutaneous coronary intervention (PCI) of long coronary artery lesions (CAL) presents a puzzle, often requiring multiple stents. As the arteries twist and narrow, this becomes even more challenging with issues like potential distal overexpansion and proximal under expansion, and edge dissections. The study aims to assess the safety and performance of BioMime™ Morph sirolimus-eluting stent (SES) in individuals with long CAL.METHODS: This prospective, single-arm, multi-center, observational, real-world registry, included 565 patients with long CAL (length 30 to ≤56 mm) in native coronary arteries (reference vessel diameters: 2.25 mm to 3.50 mm). Based on lesion length, patients were implanted with 30 mm, 40 mm, 50 mm, or 60 mm BioMime™ Morph SES. Primary endpoint was freedom of target lesion failure (TLF) at 6-month and up to 36-month.RESULTS: Over 65 % of patients had lesions requiring 50 mm and 60 mm stents. The follow-up length was up to 24-month for the whole cohort and up to 36-month only for 211 patients from seven selected centers. The freedom from TLF rate was 97.86 %, 97.26 %, 96.27 %, and 95.15 % at 6-, 12-, 24-, and 36-month follow-ups, respectively. The cumulative rates of major adverse cardiac events (MACE) were 2.74 % at 12-month, 3.73 % at 24-month and 4.85 % at 36-month. Additionally, the rates of ischemia-driven target lesion revascularization were 2.01 % at 12-month, 2.16 % at 24-month, and 3.88 % at 36-month. Lastly, stent thrombosis (ST) was reported in only 2 cases (0.97 %) at 36-month.CONCLUSION: The lower incidences of MACE and ST up to three-year follow-up indicate BioMime™ Morph SES is an effective and safe option for PCI in long CAL.
KW - BioMime Morph
KW - Long coronary lesions
KW - MACE
KW - Tapered stents
KW - Target lesion failure
UR - https://www.scopus.com/pages/publications/85219025418
U2 - 10.1016/j.carrev.2025.02.010
DO - 10.1016/j.carrev.2025.02.010
M3 - Article
C2 - 40023706
SN - 1553-8389
VL - 81
SP - 39
EP - 47
JO - Cardiovascular revascularization medicine : including molecular interventions
JF - Cardiovascular revascularization medicine : including molecular interventions
ER -