Clinical Outcomes in Early-stage NSCLC Treated with Stereotactic Body Radiotherapy Versus Surgical Resection

Elisabeth A. Kastelijn; SY el Sharouni; Frederik N. Hofman; Bart P. Van Putte; Evelyn M. Monninkhof; Marco Van Vulpen; Franz M. N. H. Schramel

Clinical Outcomes in Early-stage NSCLC Treated with Stereotactic Body Radiotherapy Versus Surgical Resection

Elisabeth A. Kastelijn, SY el Sharouni, Frederik N. Hofman, Bart P. Van Putte, Evelyn M. Monninkhof, Marco Van Vulpen, Franz M. N. H. Schramel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Surgical resection is the treatment of first choice for patients with stage I-II non-small cell lung cancer (NSCLC). However, stereotactic body radiotherapy (SBRT) has been shown to be a good alternative treatment. Patients and Methods: Overall survival (OS), progression-free survival (PFS) and recurrence rates were compared between patients with stage I-II NSCLC treated with SBRT (n=53) and those treated with surgical resection (n=175). The propensity score method was used to correct for confounding by indication. Results: Before correction, the OS and PFS rates at 1 and 3 years were significantly different between SBRT and surgery, in favor of surgery. After correction, the OS and PFS after SBRT were not significantly different compared to surgery. The recurrence rates for the two treatments were also similar both before and after correction. Conclusion: This retrospective study showed that clinical outcomes after SBRT are equal to those after surgery in patients with stage I-II NSCLC.

Original language	English
Pages (from-to)	5607-5614
Number of pages	8
Journal	Anticancer Research
Volume	35
Issue number	10
Publication status	Published - Oct 2015

Keywords

Non-small cell lung cancer
stage I-II
clinical outcome
surgery
stereotactic body radiotherapy
CELL LUNG-CANCER
ASSISTED THORACIC-SURGERY
ABLATIVE RADIOTHERAPY
RADIATION-THERAPY
MATCHED-PAIR
LOBECTOMY
SURVIVAL
DIAGNOSIS
STANDARDIZATION
THORACOTOMY

Cite this

@article{65fd881e1e754e479bf522133c37e6bc,

title = "Clinical Outcomes in Early-stage NSCLC Treated with Stereotactic Body Radiotherapy Versus Surgical Resection",

abstract = "Background: Surgical resection is the treatment of first choice for patients with stage I-II non-small cell lung cancer (NSCLC). However, stereotactic body radiotherapy (SBRT) has been shown to be a good alternative treatment. Patients and Methods: Overall survival (OS), progression-free survival (PFS) and recurrence rates were compared between patients with stage I-II NSCLC treated with SBRT (n=53) and those treated with surgical resection (n=175). The propensity score method was used to correct for confounding by indication. Results: Before correction, the OS and PFS rates at 1 and 3 years were significantly different between SBRT and surgery, in favor of surgery. After correction, the OS and PFS after SBRT were not significantly different compared to surgery. The recurrence rates for the two treatments were also similar both before and after correction. Conclusion: This retrospective study showed that clinical outcomes after SBRT are equal to those after surgery in patients with stage I-II NSCLC.",

keywords = "Non-small cell lung cancer, stage I-II, clinical outcome, surgery, stereotactic body radiotherapy, CELL LUNG-CANCER, ASSISTED THORACIC-SURGERY, ABLATIVE RADIOTHERAPY, RADIATION-THERAPY, MATCHED-PAIR, LOBECTOMY, SURVIVAL, DIAGNOSIS, STANDARDIZATION, THORACOTOMY",

author = "Kastelijn, {Elisabeth A.} and {el Sharouni}, SY and Hofman, {Frederik N.} and {Van Putte}, {Bart P.} and Monninkhof, {Evelyn M.} and {Van Vulpen}, Marco and Schramel, {Franz M. N. H.}",

year = "2015",

month = oct,

language = "English",

volume = "35",

pages = "5607--5614",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "10",

}

TY - JOUR

T1 - Clinical Outcomes in Early-stage NSCLC Treated with Stereotactic Body Radiotherapy Versus Surgical Resection

AU - Kastelijn, Elisabeth A.

AU - el Sharouni, SY

AU - Hofman, Frederik N.

AU - Van Putte, Bart P.

AU - Monninkhof, Evelyn M.

AU - Van Vulpen, Marco

AU - Schramel, Franz M. N. H.

PY - 2015/10

Y1 - 2015/10

N2 - Background: Surgical resection is the treatment of first choice for patients with stage I-II non-small cell lung cancer (NSCLC). However, stereotactic body radiotherapy (SBRT) has been shown to be a good alternative treatment. Patients and Methods: Overall survival (OS), progression-free survival (PFS) and recurrence rates were compared between patients with stage I-II NSCLC treated with SBRT (n=53) and those treated with surgical resection (n=175). The propensity score method was used to correct for confounding by indication. Results: Before correction, the OS and PFS rates at 1 and 3 years were significantly different between SBRT and surgery, in favor of surgery. After correction, the OS and PFS after SBRT were not significantly different compared to surgery. The recurrence rates for the two treatments were also similar both before and after correction. Conclusion: This retrospective study showed that clinical outcomes after SBRT are equal to those after surgery in patients with stage I-II NSCLC.

AB - Background: Surgical resection is the treatment of first choice for patients with stage I-II non-small cell lung cancer (NSCLC). However, stereotactic body radiotherapy (SBRT) has been shown to be a good alternative treatment. Patients and Methods: Overall survival (OS), progression-free survival (PFS) and recurrence rates were compared between patients with stage I-II NSCLC treated with SBRT (n=53) and those treated with surgical resection (n=175). The propensity score method was used to correct for confounding by indication. Results: Before correction, the OS and PFS rates at 1 and 3 years were significantly different between SBRT and surgery, in favor of surgery. After correction, the OS and PFS after SBRT were not significantly different compared to surgery. The recurrence rates for the two treatments were also similar both before and after correction. Conclusion: This retrospective study showed that clinical outcomes after SBRT are equal to those after surgery in patients with stage I-II NSCLC.

KW - Non-small cell lung cancer

KW - stage I-II

KW - clinical outcome

KW - surgery

KW - stereotactic body radiotherapy

KW - CELL LUNG-CANCER

KW - ASSISTED THORACIC-SURGERY

KW - ABLATIVE RADIOTHERAPY

KW - RADIATION-THERAPY

KW - MATCHED-PAIR

KW - LOBECTOMY

KW - SURVIVAL

KW - DIAGNOSIS

KW - STANDARDIZATION

KW - THORACOTOMY

UR - http://www.ncbi.nlm.nih.gov/pubmed/26408733

M3 - Article

SN - 0250-7005

VL - 35

SP - 5607

EP - 5614

JO - Anticancer Research

JF - Anticancer Research

IS - 10

ER -

Clinical Outcomes in Early-stage NSCLC Treated with Stereotactic Body Radiotherapy Versus Surgical Resection

Abstract

Keywords

Other files and links

Fingerprint

Cite this