Clinical experience of preimplantation genetic testing

Martine De Rycke; Veerle Berckmoes; Anick De Vos; Stefanie Van De Voorde; Pieter Verdyck; Willem Verpoest; Kathelijn Keymolen

doi:10.1530/REP-20-0082

Clinical experience of preimplantation genetic testing

Martine De Rycke^*, Veerle Berckmoes, Anick De Vos, Stefanie Van De Voorde, Pieter Verdyck, Willem Verpoest, Kathelijn Keymolen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Thirty years of rapid technological advances in the field of genetic testing and assisted reproduction have reshaped the procedure of preimplantation genetic testing (PGT). The development of whole genome amplification and genome-wide testing tools together with the implementation of optimal hormonal stimulation protocols and more efficient cryopreservation methods have led to more accurate diagnoses and improved clinical outcomes. In addition, the shift towards embryo biopsy at day 5/6 has changed the timeline of a typical PGT clinical procedure. In this paper, we present an up-to-date overview of the different steps in PGT from patient referral to baby follow-up.

Original language	English
Pages (from-to)	A45-A58
Journal	Reproduction
Volume	160
Issue number	5
DOIs	https://doi.org/10.1530/REP-20-0082
Publication status	Published - Nov 2020
Externally published	Yes

Keywords

Chromosome Aberrations
Female
Fetal Diseases/diagnosis
Genetic Diseases, Inborn/diagnosis
Genetic Testing/methods
Humans
Pregnancy
Preimplantation Diagnosis/methods

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10.1530/REP-20-0082

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abstract = "Thirty years of rapid technological advances in the field of genetic testing and assisted reproduction have reshaped the procedure of preimplantation genetic testing (PGT). The development of whole genome amplification and genome-wide testing tools together with the implementation of optimal hormonal stimulation protocols and more efficient cryopreservation methods have led to more accurate diagnoses and improved clinical outcomes. In addition, the shift towards embryo biopsy at day 5/6 has changed the timeline of a typical PGT clinical procedure. In this paper, we present an up-to-date overview of the different steps in PGT from patient referral to baby follow-up.",

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AU - De Rycke, Martine

AU - Berckmoes, Veerle

AU - De Vos, Anick

AU - Van De Voorde, Stefanie

AU - Verdyck, Pieter

AU - Verpoest, Willem

AU - Keymolen, Kathelijn

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Clinical experience of preimplantation genetic testing

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Keywords

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