Clinical Characteristics, Treatment Considerations, and Outcomes of Infants with Rhabdomyosarcoma

Adam P. Yan; Rajkumar Venkatramani; Julie A. Bradley; Timothy B. Lautz; Cristian I. Urla; Johannes H.M. Merks; Sapna Oberoi

doi:10.3390/cancers15082296

Clinical Characteristics, Treatment Considerations, and Outcomes of Infants with Rhabdomyosarcoma

Adam P. Yan, Rajkumar Venkatramani, Julie A. Bradley, Timothy B. Lautz, Cristian I. Urla, Johannes H.M. Merks, Sapna Oberoi^*

^*Corresponding author for this work

Imaging - research

Research output: Contribution to journal › Review article › peer-review

Abstract

RMS most commonly presents in children and adolescents, however a subset of tumors are diagnosed in infants under one year of age. Due to the rarity of infant RMS, utilization of different treatment approaches and goals, and small sample sizes, the published studies of infants with RMS have yielded heterogeneous results. In this review, we discuss the outcomes of infants with RMS treated in various clinical trials and the strategies that various international cooperative groups have employed to reduce the morbidity and mortality related to treatment without compromising the overall survival of this population. This review discusses the unique scenarios of diagnosing and managing congenitals or neonatal RMS, spindle cell RMS and relapsed RMS. This review concludes by exploring novel approaches to diagnosis and management of infants with RMS that are currently being studied by various international cooperative groups.

Original language	English
Article number	2296
Journal	Cancers
Volume	15
Issue number	8
DOIs	https://doi.org/10.3390/cancers15082296
Publication status	Published - Apr 2023

Keywords

infant
pediatric
rhabdomyosarcoma
sarcoma

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cancers-15-02296Final published version, 327 KBLicence: CC BY

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title = "Clinical Characteristics, Treatment Considerations, and Outcomes of Infants with Rhabdomyosarcoma",

abstract = "RMS most commonly presents in children and adolescents, however a subset of tumors are diagnosed in infants under one year of age. Due to the rarity of infant RMS, utilization of different treatment approaches and goals, and small sample sizes, the published studies of infants with RMS have yielded heterogeneous results. In this review, we discuss the outcomes of infants with RMS treated in various clinical trials and the strategies that various international cooperative groups have employed to reduce the morbidity and mortality related to treatment without compromising the overall survival of this population. This review discusses the unique scenarios of diagnosing and managing congenitals or neonatal RMS, spindle cell RMS and relapsed RMS. This review concludes by exploring novel approaches to diagnosis and management of infants with RMS that are currently being studied by various international cooperative groups.",

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author = "Yan, {Adam P.} and Rajkumar Venkatramani and Bradley, {Julie A.} and Lautz, {Timothy B.} and Urla, {Cristian I.} and Merks, {Johannes H.M.} and Sapna Oberoi",

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T1 - Clinical Characteristics, Treatment Considerations, and Outcomes of Infants with Rhabdomyosarcoma

AU - Yan, Adam P.

AU - Venkatramani, Rajkumar

AU - Bradley, Julie A.

AU - Lautz, Timothy B.

AU - Urla, Cristian I.

AU - Merks, Johannes H.M.

AU - Oberoi, Sapna

PY - 2023/4

Y1 - 2023/4

N2 - RMS most commonly presents in children and adolescents, however a subset of tumors are diagnosed in infants under one year of age. Due to the rarity of infant RMS, utilization of different treatment approaches and goals, and small sample sizes, the published studies of infants with RMS have yielded heterogeneous results. In this review, we discuss the outcomes of infants with RMS treated in various clinical trials and the strategies that various international cooperative groups have employed to reduce the morbidity and mortality related to treatment without compromising the overall survival of this population. This review discusses the unique scenarios of diagnosing and managing congenitals or neonatal RMS, spindle cell RMS and relapsed RMS. This review concludes by exploring novel approaches to diagnosis and management of infants with RMS that are currently being studied by various international cooperative groups.

AB - RMS most commonly presents in children and adolescents, however a subset of tumors are diagnosed in infants under one year of age. Due to the rarity of infant RMS, utilization of different treatment approaches and goals, and small sample sizes, the published studies of infants with RMS have yielded heterogeneous results. In this review, we discuss the outcomes of infants with RMS treated in various clinical trials and the strategies that various international cooperative groups have employed to reduce the morbidity and mortality related to treatment without compromising the overall survival of this population. This review discusses the unique scenarios of diagnosing and managing congenitals or neonatal RMS, spindle cell RMS and relapsed RMS. This review concludes by exploring novel approaches to diagnosis and management of infants with RMS that are currently being studied by various international cooperative groups.

KW - infant

KW - pediatric

KW - rhabdomyosarcoma

KW - sarcoma

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U2 - 10.3390/cancers15082296

DO - 10.3390/cancers15082296

M3 - Review article

AN - SCOPUS:85153871381

SN - 2072-6694

VL - 15

JO - Cancers

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ER -

Clinical Characteristics, Treatment Considerations, and Outcomes of Infants with Rhabdomyosarcoma

Abstract

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