Clinical application of the 70-gene profile: The MINDACT trial

Fatima Cardoso; Laura Van't Veer; Emiel Rutgers; Sherene Loi; Stella Mook; Martine J. Piccart-Gebhart

doi:10.1200/JCO.2007.14.3222

Clinical application of the 70-gene profile: The MINDACT trial

Fatima Cardoso
, Laura Van't Veer
, Emiel Rutgers
, Sherene Loi
, Stella Mook
, Martine J. Piccart-Gebhart^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

387 Citations (Scopus)

Abstract

The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.

Original language	English
Pages (from-to)	729-735
Number of pages	7
Journal	Journal of Clinical Oncology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1200/JCO.2007.14.3222
Publication status	Published - 2 Feb 2008
Externally published	Yes

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10.1200/JCO.2007.14.3222

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abstract = "The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.",

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AU - Cardoso, Fatima

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AU - Rutgers, Emiel

AU - Loi, Sherene

AU - Mook, Stella

AU - Piccart-Gebhart, Martine J.

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AB - The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.

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Clinical application of the 70-gene profile: The MINDACT trial

Abstract

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