TY - JOUR
T1 - Clinical application of the 70-gene profile
T2 - The MINDACT trial
AU - Cardoso, Fatima
AU - Van't Veer, Laura
AU - Rutgers, Emiel
AU - Loi, Sherene
AU - Mook, Stella
AU - Piccart-Gebhart, Martine J.
PY - 2008/2/2
Y1 - 2008/2/2
N2 - The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.
AB - The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.
UR - https://www.scopus.com/pages/publications/39149123547
U2 - 10.1200/JCO.2007.14.3222
DO - 10.1200/JCO.2007.14.3222
M3 - Review article
C2 - 18258980
AN - SCOPUS:39149123547
SN - 0732-183X
VL - 26
SP - 729
EP - 735
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 5
ER -