Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis

Antoine W T van Lieshout; Calin Popa; Friederike Meyer-Wentrup; Heidi L Lemmers; Anton F Stalenhoef; Gosse J Adema; Piet L C M van Riel; Lambertus J van Tits; Timothy R D J Radstake

doi:10.1016/j.bbrc.2007.01.161

Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis

Antoine W T van Lieshout, Calin Popa, Friederike Meyer-Wentrup, Heidi L Lemmers, Anton F Stalenhoef, Gosse J Adema, Piet L C M van Riel, Lambertus J van Tits, Timothy R D J Radstake

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

CXCL16 acts as a scavenger receptor for oxLDL in its membrane-bound form and induces migration of activated T cells in its soluble form. Due to these properties, CXCL16 has been suggested to play a role in both atherosclerosis and rheumatoid arthritis (RA). Our aim was to evaluate the contribution of soluble CXCL16 to the scavenging of oxLDL and its potential as a marker for cardiovascular disease (CVD) in patients with RA. We found that circulating CXCL16 was not correlated with plasma oxLDL or ApoB and was not related to the presence of CVD in RA patients. Moreover, CXCL16 did not bind and scavenge oxLDL in an in vitro setting. These data suggest that binding of oxLDL by soluble CXCL16 does not play a role in atherosclerosis and, although confirmation in larger studies is needed, that circulating CXCL16 is not related to the presence of CVD in patients with RA.

Original language	English
Pages (from-to)	392-7
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	355
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2007.01.161
Publication status	Published - 6 Apr 2007

Keywords

Adult
Aged
Arthritis, Rheumatoid
Chemokines, CXC
Enzyme-Linked Immunosorbent Assay
Humans
Lipoproteins, LDL
Middle Aged
Receptors, Scavenger
Journal Article

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10.1016/j.bbrc.2007.01.161

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van Lieshout, A. W. T., Popa, C., Meyer-Wentrup, F., Lemmers, H. L., Stalenhoef, A. F., Adema, G. J., van Riel, P. L. C. M., van Tits, L. J., & Radstake, T. R. D. J. (2007). Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis. Biochemical and Biophysical Research Communications, 355(2), 392-7. https://doi.org/10.1016/j.bbrc.2007.01.161

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title = "Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis",

abstract = "CXCL16 acts as a scavenger receptor for oxLDL in its membrane-bound form and induces migration of activated T cells in its soluble form. Due to these properties, CXCL16 has been suggested to play a role in both atherosclerosis and rheumatoid arthritis (RA). Our aim was to evaluate the contribution of soluble CXCL16 to the scavenging of oxLDL and its potential as a marker for cardiovascular disease (CVD) in patients with RA. We found that circulating CXCL16 was not correlated with plasma oxLDL or ApoB and was not related to the presence of CVD in RA patients. Moreover, CXCL16 did not bind and scavenge oxLDL in an in vitro setting. These data suggest that binding of oxLDL by soluble CXCL16 does not play a role in atherosclerosis and, although confirmation in larger studies is needed, that circulating CXCL16 is not related to the presence of CVD in patients with RA.",

keywords = "Adult, Aged, Arthritis, Rheumatoid, Chemokines, CXC, Enzyme-Linked Immunosorbent Assay, Humans, Lipoproteins, LDL, Middle Aged, Receptors, Scavenger, Journal Article",

author = "{van Lieshout}, {Antoine W T} and Calin Popa and Friederike Meyer-Wentrup and Lemmers, {Heidi L} and Stalenhoef, {Anton F} and Adema, {Gosse J} and {van Riel}, {Piet L C M} and {van Tits}, {Lambertus J} and Radstake, {Timothy R D J}",

year = "2007",

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doi = "10.1016/j.bbrc.2007.01.161",

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T1 - Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis

AU - van Lieshout, Antoine W T

AU - Popa, Calin

AU - Meyer-Wentrup, Friederike

AU - Lemmers, Heidi L

AU - Stalenhoef, Anton F

AU - Adema, Gosse J

AU - van Riel, Piet L C M

AU - van Tits, Lambertus J

AU - Radstake, Timothy R D J

PY - 2007/4/6

Y1 - 2007/4/6

N2 - CXCL16 acts as a scavenger receptor for oxLDL in its membrane-bound form and induces migration of activated T cells in its soluble form. Due to these properties, CXCL16 has been suggested to play a role in both atherosclerosis and rheumatoid arthritis (RA). Our aim was to evaluate the contribution of soluble CXCL16 to the scavenging of oxLDL and its potential as a marker for cardiovascular disease (CVD) in patients with RA. We found that circulating CXCL16 was not correlated with plasma oxLDL or ApoB and was not related to the presence of CVD in RA patients. Moreover, CXCL16 did not bind and scavenge oxLDL in an in vitro setting. These data suggest that binding of oxLDL by soluble CXCL16 does not play a role in atherosclerosis and, although confirmation in larger studies is needed, that circulating CXCL16 is not related to the presence of CVD in patients with RA.

AB - CXCL16 acts as a scavenger receptor for oxLDL in its membrane-bound form and induces migration of activated T cells in its soluble form. Due to these properties, CXCL16 has been suggested to play a role in both atherosclerosis and rheumatoid arthritis (RA). Our aim was to evaluate the contribution of soluble CXCL16 to the scavenging of oxLDL and its potential as a marker for cardiovascular disease (CVD) in patients with RA. We found that circulating CXCL16 was not correlated with plasma oxLDL or ApoB and was not related to the presence of CVD in RA patients. Moreover, CXCL16 did not bind and scavenge oxLDL in an in vitro setting. These data suggest that binding of oxLDL by soluble CXCL16 does not play a role in atherosclerosis and, although confirmation in larger studies is needed, that circulating CXCL16 is not related to the presence of CVD in patients with RA.

KW - Adult

KW - Aged

KW - Arthritis, Rheumatoid

KW - Chemokines, CXC

KW - Enzyme-Linked Immunosorbent Assay

KW - Humans

KW - Lipoproteins, LDL

KW - Middle Aged

KW - Receptors, Scavenger

KW - Journal Article

U2 - 10.1016/j.bbrc.2007.01.161

DO - 10.1016/j.bbrc.2007.01.161

M3 - Article

C2 - 17300746

SN - 0006-291X

VL - 355

SP - 392

EP - 397

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis

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