@article{829891b157c541efbafba293a5d57732,
title = "Circle of Willis variations in migraine patients with ischemic stroke",
abstract = "Objectives Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine. Materials and Methods Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness/hypoplasia (any segment <1 mm), for anterior cerebral artery asymmetry (difference > 1/3), and for posterior communicating artery (Pcom) dominance (Pcom–P1 difference > 1/3). Odds ratios with adjustments for age and sex (aOR) were calculated with logistic regression. Results We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87%) had an incomplete or hypoplastic CoW versus 506 (85%) of the 594 participants without migraine (aOR: 1.47; 95% CI: 0.63–3.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry (aOR: 0.86; 95% CI: 0.43–1.74), or Pcom dominance (aOR: 0.64; 95% CI: 0.32–1.30). There were no differences in CoW variations between migraine patients with or without aura. Conclusion We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.",
keywords = "Adult, Aged, Analysis of Variance, Brain Ischemia/diagnosis, Brain/blood supply, Circle of Willis/diagnostic imaging, Computed Tomography Angiography/methods, Female, Humans, Male, Middle Aged, Migraine Disorders/complications, Prevalence, Prospective Studies, Risk Factors, Stroke/complications",
author = "Hamming, {Arend M.} and {van Walderveen}, {Marianne A. A.} and Mulder, {Inge A.} and {van der Schaaf}, {Irene C.} and Kappelle, {L. Jaap} and Velthuis, {Birgitta K.} and Ferrari, {Michel D.} and Terwindt, {Gisela M.} and Visser, {Marieke C.} and Wouter Schonewille and Ale Algra and Wermer, {Marieke J. H.} and Majoie, {C. B.} and Roos, {Y. B.} and Duijm, {L. E.} and K. Keizer and {van der Lugt}, A. and Dippel, {D. W.} and {Droogh-de Greeve}, {K. E.} and Bienfait, {H. P.} and {Lycklama a Nijeholt}, {G. J.} and J. Boiten and D. Duyndam and Kwa, {V., I} and Meijer, {F. J.} and {van Dijk}, {E. J.} and Kesselring, {F. O.} and J. Hofmeijer and Vos, {J. A.} and {van Rooij}, {W. J.} and {de Kort}, {P. L.} and Pleiter, {C. C.} and Bakker, {S. L.} and J. Bot and Velthuis, {Birgitta K.} and Dankbaar, {J. W.} and Mali, {W. P.} and {van Seeters}, T. and Horsch, {A. D.} and Niesten, {J. M.} and Biessels, {G. J.} and Luitse, {M. J.} and {van der Graaf}, Y.",
note = "Funding Information: Netherlands Organization for Scientific Research; Dutch Heart Foundation, Grant/Award Number: 2011T055 and 2008T034; Dutch Brain Foundation, Grant/ Award Number: F2014(1)‐22; NutsOhra Foundation, Grant/Award Number: 0903‐012 Funding Information: The authors acknowledge all Dutch acute stroke trial (DUST) investigators. The Dutch acute stroke trial (DUST) investigators are: Academic Medical Center, Amsterdam, The Netherlands (Majoie CB, Roos YB); Catharina Hospital, Eindhoven, The Netherlands (Duijm LE, Keizer K); Erasmus Medical Center, Rotterdam, The Netherlands (van der Lugt A, Dippel DW); Gelre Hospitals, Apeldoorn, The Netherlands (Droogh - de Greeve KE, Bienfait HP); Leiden University Medical Center, Leiden, The Netherlands (van Walderveen MA, Wermer MJ); Medical Center Haaglanden, The Hague, The Netherlands (Lycklama ? Nijeholt GJ, Boiten J); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (Duyndam D, Kwa VI); Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands (Meijer FJ, van Dijk EJ); Rijnstate Hospital, Arnhem, The Netherlands (Kesselring FO, Hofmeijer J); St. Antonius Hospital, Nieuwegein, The Netherlands (Vos JA, Schonewille WJ); St. Elisabeth Hospital, Tilburg, The Netherlands (van Rooij WJ, de Kort PL); St. Franciscus Hospital, Rotterdam, The Netherlands (Pleiter CC, Bakker SL); VU Medical Center, Amsterdam, The Netherlands (Bot J, Visser MC); University Medical Center Utrecht, Utrecht, The Netherlands (Velthuis BK, van der Schaaf IC, Dankbaar JW, Mali WP, van Seeters T, Horsch AD, Niesten JM, Biessels GJ, Kappelle LJ, Luitse MJ, van der Graaf Y). Funding Information: Dr. Wermer was supported by a personal grant from the Netherlands Organization for Scientific Research (ZonMW Veni grant), the Dutch Heart Foundation (2011T055), and the Dutch Brain Foundation (F2014(1)‐22). The DUST study was supported by a grant from the Dutch Heart Foundation (2008T034) and the NutsOhra Foundation (0903‐012). Publisher Copyright: {\textcopyright} 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.",
year = "2019",
month = mar,
doi = "10.1002/brb3.1223",
language = "English",
volume = "9",
pages = "e01223",
number = "3",
}