Chronic pancreatitis

Naomi DE Thierens; Robert C. Verdonk; J. Matthias Löhr; Hjalmar C. van Santvoort; Stefan AW Bouwense; Jeanin E. van Hooft

doi:10.1016/S0140-6736(24)02187-1

Chronic pancreatitis

Naomi DE Thierens^*, Robert C. Verdonk, J. Matthias Löhr, Hjalmar C. van Santvoort, Stefan AW Bouwense, Jeanin E. van Hooft

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality. The diagnosis is based on the presence of typical symptoms and multiple morphological manifestations of the pancreas, including pancreatic duct stones and strictures, parenchymal calcifications, and pseudocysts. Management of chronic pancreatitis consists of prevention and treatment of complications, requiring a multidisciplinary approach focusing on lifestyle modifications, exocrine insufficiency, nutritional status, bone health, endocrine insufficiency, pain management, and psychological care. To optimise clinical outcomes, screening for complications and evaluation of treatment efficacy are indicated in all patients with chronic pancreatitis.

Original language	English
Pages (from-to)	2605-2618
Number of pages	14
Journal	The Lancet
Volume	404
Issue number	10471
DOIs	https://doi.org/10.1016/S0140-6736(24)02187-1
Publication status	Published - 21 Dec 2024

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10.1016/S0140-6736(24)02187-1

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title = "Chronic pancreatitis",

abstract = "Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality. The diagnosis is based on the presence of typical symptoms and multiple morphological manifestations of the pancreas, including pancreatic duct stones and strictures, parenchymal calcifications, and pseudocysts. Management of chronic pancreatitis consists of prevention and treatment of complications, requiring a multidisciplinary approach focusing on lifestyle modifications, exocrine insufficiency, nutritional status, bone health, endocrine insufficiency, pain management, and psychological care. To optimise clinical outcomes, screening for complications and evaluation of treatment efficacy are indicated in all patients with chronic pancreatitis.",

author = "Thierens, {Naomi DE} and Verdonk, {Robert C.} and L{\"o}hr, {J. Matthias} and {van Santvoort}, {Hjalmar C.} and Bouwense, {Stefan AW} and {van Hooft}, {Jeanin E.}",

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TY - JOUR

T1 - Chronic pancreatitis

AU - Thierens, Naomi DE

AU - Verdonk, Robert C.

AU - Löhr, J. Matthias

AU - van Santvoort, Hjalmar C.

AU - Bouwense, Stefan AW

AU - van Hooft, Jeanin E.

PY - 2024/12/21

Y1 - 2024/12/21

N2 - Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality. The diagnosis is based on the presence of typical symptoms and multiple morphological manifestations of the pancreas, including pancreatic duct stones and strictures, parenchymal calcifications, and pseudocysts. Management of chronic pancreatitis consists of prevention and treatment of complications, requiring a multidisciplinary approach focusing on lifestyle modifications, exocrine insufficiency, nutritional status, bone health, endocrine insufficiency, pain management, and psychological care. To optimise clinical outcomes, screening for complications and evaluation of treatment efficacy are indicated in all patients with chronic pancreatitis.

AB - Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality. The diagnosis is based on the presence of typical symptoms and multiple morphological manifestations of the pancreas, including pancreatic duct stones and strictures, parenchymal calcifications, and pseudocysts. Management of chronic pancreatitis consists of prevention and treatment of complications, requiring a multidisciplinary approach focusing on lifestyle modifications, exocrine insufficiency, nutritional status, bone health, endocrine insufficiency, pain management, and psychological care. To optimise clinical outcomes, screening for complications and evaluation of treatment efficacy are indicated in all patients with chronic pancreatitis.

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U2 - 10.1016/S0140-6736(24)02187-1

DO - 10.1016/S0140-6736(24)02187-1

M3 - Review article

C2 - 39647500

AN - SCOPUS:85212348492

SN - 0140-6736

VL - 404

SP - 2605

EP - 2618

JO - The Lancet

JF - The Lancet

IS - 10471

ER -

Chronic pancreatitis

Abstract

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