Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease

J H Sillevis Smitt, J H Leusen, H G Stas, A H Teeuw, R S Weening

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A 12 year old boy suffering from p67-phox deficient chronic granulomatous disease presented with a bullous skin disease and a lung infection with paecilomyces species. The histopathology of a bullous lesion showed subepidermal blister formation and microabcesses containing eosinophils in the dermal papillae. By direct immunofluorescence, linear staining of IgA at the dermal-epidermal junction was detected which confirmed the clinical diagnosis of chronic bullous disease of childhood (linear IgA dermatosis).

Original languageEnglish
Pages (from-to)150-2
Number of pages3
JournalArchives of Disease in Childhood
Volume77
Issue number2
Publication statusPublished - Aug 1997

Keywords

  • Amphotericin B
  • Anti-Inflammatory Agents
  • Antifungal Agents
  • Autoimmune Diseases
  • Child
  • Drug Therapy, Combination
  • Granulomatous Disease, Chronic
  • Humans
  • Itraconazole
  • Lung Diseases, Fungal
  • Male
  • Paecilomyces
  • Phosphoproteins
  • Prednisolone
  • Skin Diseases, Vesiculobullous
  • Case Reports
  • Journal Article

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