Cholesterol and age-related macular degeneration: is there a link?

Redmer van Leeuwen; Caroline C W Klaver; Johannes R Vingerling; Albert Hofman; Cornelia M van Duijn; Bruno H Ch Stricker; Paulus T V M de Jong

doi:10.1016/j.ajo.2003.09.015

Cholesterol and age-related macular degeneration: is there a link?

Redmer van Leeuwen, Caroline C W Klaver, Johannes R Vingerling, Albert Hofman, Cornelia M van Duijn, Bruno H Ch Stricker, Paulus T V M de Jong

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD).

DESIGN: The Rotterdam Study, a population based prospective cohort study.

METHODS: Serum levels of total and high-density lipoprotein (HDL) cholesterol as well as APOE genotype were determined at baseline. Of 3,944 subjects, 400 were diagnosed with incident early and late AMD after a mean follow-up of 5.2 years.

RESULTS: Serum HDL, but not total, cholesterol was associated with an increased risk of AMD (odds ratio/SD, 1.20; 95% confidence interval; 1.06-1.35). The association remained unchanged after adjustment for APOE genotype. When stratifying for APOE genotype, the association was strongest in persons with the e 4 allele; an inverse association seemed to be present for e 2 carriers.

CONCLUSION: Elevated HDL but not total cholesterol is associated with an increased risk of AMD. Apolipoprotein E genotype does not explain this association but may be an effect modifier.

Original language	English
Pages (from-to)	750-2
Number of pages	3
Journal	American Journal of Ophthalmology
Volume	137
Issue number	4
DOIs	https://doi.org/10.1016/j.ajo.2003.09.015
Publication status	Published - Apr 2004
Externally published	Yes

Keywords

Apolipoproteins E
Cholesterol
Cholesterol, HDL
Genotype
Humans
Macular Degeneration
Middle Aged
Prospective Studies
Risk Factors
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.ajo.2003.09.015

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title = "Cholesterol and age-related macular degeneration: is there a link?",

abstract = "PURPOSE: To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD).DESIGN: The Rotterdam Study, a population based prospective cohort study.METHODS: Serum levels of total and high-density lipoprotein (HDL) cholesterol as well as APOE genotype were determined at baseline. Of 3,944 subjects, 400 were diagnosed with incident early and late AMD after a mean follow-up of 5.2 years.RESULTS: Serum HDL, but not total, cholesterol was associated with an increased risk of AMD (odds ratio/SD, 1.20; 95% confidence interval; 1.06-1.35). The association remained unchanged after adjustment for APOE genotype. When stratifying for APOE genotype, the association was strongest in persons with the e 4 allele; an inverse association seemed to be present for e 2 carriers.CONCLUSION: Elevated HDL but not total cholesterol is associated with an increased risk of AMD. Apolipoprotein E genotype does not explain this association but may be an effect modifier.",

keywords = "Apolipoproteins E, Cholesterol, Cholesterol, HDL, Genotype, Humans, Macular Degeneration, Middle Aged, Prospective Studies, Risk Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "{van Leeuwen}, Redmer and Klaver, {Caroline C W} and Vingerling, {Johannes R} and Albert Hofman and {van Duijn}, {Cornelia M} and Stricker, {Bruno H Ch} and {de Jong}, {Paulus T V M}",

year = "2004",

month = apr,

doi = "10.1016/j.ajo.2003.09.015",

language = "English",

volume = "137",

pages = "750--2",

journal = "American Journal of Ophthalmology",

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TY - JOUR

T1 - Cholesterol and age-related macular degeneration

T2 - is there a link?

AU - van Leeuwen, Redmer

AU - Klaver, Caroline C W

AU - Vingerling, Johannes R

AU - Hofman, Albert

AU - van Duijn, Cornelia M

AU - Stricker, Bruno H Ch

AU - de Jong, Paulus T V M

PY - 2004/4

Y1 - 2004/4

N2 - PURPOSE: To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD).DESIGN: The Rotterdam Study, a population based prospective cohort study.METHODS: Serum levels of total and high-density lipoprotein (HDL) cholesterol as well as APOE genotype were determined at baseline. Of 3,944 subjects, 400 were diagnosed with incident early and late AMD after a mean follow-up of 5.2 years.RESULTS: Serum HDL, but not total, cholesterol was associated with an increased risk of AMD (odds ratio/SD, 1.20; 95% confidence interval; 1.06-1.35). The association remained unchanged after adjustment for APOE genotype. When stratifying for APOE genotype, the association was strongest in persons with the e 4 allele; an inverse association seemed to be present for e 2 carriers.CONCLUSION: Elevated HDL but not total cholesterol is associated with an increased risk of AMD. Apolipoprotein E genotype does not explain this association but may be an effect modifier.

AB - PURPOSE: To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD).DESIGN: The Rotterdam Study, a population based prospective cohort study.METHODS: Serum levels of total and high-density lipoprotein (HDL) cholesterol as well as APOE genotype were determined at baseline. Of 3,944 subjects, 400 were diagnosed with incident early and late AMD after a mean follow-up of 5.2 years.RESULTS: Serum HDL, but not total, cholesterol was associated with an increased risk of AMD (odds ratio/SD, 1.20; 95% confidence interval; 1.06-1.35). The association remained unchanged after adjustment for APOE genotype. When stratifying for APOE genotype, the association was strongest in persons with the e 4 allele; an inverse association seemed to be present for e 2 carriers.CONCLUSION: Elevated HDL but not total cholesterol is associated with an increased risk of AMD. Apolipoprotein E genotype does not explain this association but may be an effect modifier.

KW - Apolipoproteins E

KW - Cholesterol

KW - Cholesterol, HDL

KW - Genotype

KW - Humans

KW - Macular Degeneration

KW - Middle Aged

KW - Prospective Studies

KW - Risk Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ajo.2003.09.015

DO - 10.1016/j.ajo.2003.09.015

M3 - Article

C2 - 15059717

SN - 0002-9394

VL - 137

SP - 750

EP - 752

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 4

ER -

Cholesterol and age-related macular degeneration: is there a link?

Abstract

Keywords

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