Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

Marcus J Rijken; Machteld E Boel; Bruce Russell; Mallika Imwong; Mara L Leimanis; Aung Pyae Phyo; Atis Muehlenbachs; Niklas Lindegardh; Rose McGready; Laurent Rénia; Georges Snounou; Pratap Singhasivanon; François Nosten

doi:10.1186/1475-2875-10-113

Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

Marcus J Rijken, Machteld E Boel, Bruce Russell, Mallika Imwong, Mara L Leimanis, Aung Pyae Phyo, Atis Muehlenbachs, Niklas Lindegardh, Rose McGready, Laurent Rénia, Georges Snounou, Pratap Singhasivanon, François Nosten

Birth Center Obstetrics - Medical

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

Original language	English
Pages (from-to)	113
Journal	Malaria Journal
Volume	10
DOIs	https://doi.org/10.1186/1475-2875-10-113
Publication status	Published - 2011

Keywords

Adult
Antimalarials
Chloroquine
DNA, Protozoan
Drug Resistance
Female
Genotype
Humans
Malaria, Vivax
Parasitic Sensitivity Tests
Plasmodium vivax
Pregnancy
Pregnancy Complications, Infectious
Thailand
Case Reports
Journal Article
Research Support, Non-U.S. Gov't

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10.1186/1475-2875-10-113

Cite this

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title = "Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand",

abstract = "Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.",

keywords = "Adult, Antimalarials, Chloroquine, DNA, Protozoan, Drug Resistance, Female, Genotype, Humans, Malaria, Vivax, Parasitic Sensitivity Tests, Plasmodium vivax, Pregnancy, Pregnancy Complications, Infectious, Thailand, Case Reports, Journal Article, Research Support, Non-U.S. Gov't",

author = "Rijken, {Marcus J} and Boel, {Machteld E} and Bruce Russell and Mallika Imwong and Leimanis, {Mara L} and Phyo, {Aung Pyae} and Atis Muehlenbachs and Niklas Lindegardh and Rose McGready and Laurent R{\'e}nia and Georges Snounou and Pratap Singhasivanon and Fran{\c c}ois Nosten",

year = "2011",

doi = "10.1186/1475-2875-10-113",

language = "English",

volume = "10",

pages = "113",

journal = "Malaria Journal",

issn = "1475-2875",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

AU - Rijken, Marcus J

AU - Boel, Machteld E

AU - Russell, Bruce

AU - Imwong, Mallika

AU - Leimanis, Mara L

AU - Phyo, Aung Pyae

AU - Muehlenbachs, Atis

AU - Lindegardh, Niklas

AU - McGready, Rose

AU - Rénia, Laurent

AU - Snounou, Georges

AU - Singhasivanon, Pratap

AU - Nosten, François

PY - 2011

Y1 - 2011

N2 - Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

AB - Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

KW - Adult

KW - Antimalarials

KW - Chloroquine

KW - DNA, Protozoan

KW - Drug Resistance

KW - Female

KW - Genotype

KW - Humans

KW - Malaria, Vivax

KW - Parasitic Sensitivity Tests

KW - Plasmodium vivax

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - Thailand

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/1475-2875-10-113

DO - 10.1186/1475-2875-10-113

M3 - Article

C2 - 21545737

SN - 1475-2875

VL - 10

SP - 113

JO - Malaria Journal

JF - Malaria Journal

ER -

Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

Abstract

Keywords

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