Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials

Carmine Zoccali; Peter J Blankestijn; Annette Bruchfeld; Giovambattista Capasso; Danilo Fliser; Denis Fouque; Dimitrios Goumenos; Markus Ketteler; Ziad Massy; Ivan Rychlık; Maria Soler; Kate Stevens; Goce Spasovski; Christoph Wanner

doi:10.1093/ndt/gfz023

Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials

Carmine Zoccali, Peter J Blankestijn, Annette Bruchfeld, Giovambattista Capasso, Danilo Fliser, Denis Fouque, Dimitrios Goumenos, Markus Ketteler, Ziad Massy, Ivan Rychlık, Maria Soler, Kate Stevens, Goce Spasovski, Christoph Wanner

Research output: Contribution to journal › Review article › peer-review

Abstract

The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.

Original language	English
Pages (from-to)	1112-1114
Number of pages	3
Journal	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume	34
Issue number	7
Early online date	27 Feb 2019
DOIs	https://doi.org/10.1093/ndt/gfz023
Publication status	Published - Jul 2019

Keywords

CKD
Cardiovascular
Clinical trial
Diabetes mellitus
Guidelines
clinical trial
guidelines
diabetes mellitus
cardiovascular

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10.1093/ndt/gfz023

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Zoccali, C., Blankestijn, P. J., Bruchfeld, A., Capasso, G., Fliser, D., Fouque, D., Goumenos, D., Ketteler, M., Massy, Z., Rychlık, I., Soler, M., Stevens, K., Spasovski, G., & Wanner, C. (2019). Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 34(7), 1112-1114. https://doi.org/10.1093/ndt/gfz023

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title = "Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials",

abstract = "The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.",

keywords = "CKD, Cardiovascular, Clinical trial, Diabetes mellitus, Guidelines, clinical trial, guidelines, diabetes mellitus, cardiovascular",

author = "Carmine Zoccali and Blankestijn, {Peter J} and Annette Bruchfeld and Giovambattista Capasso and Danilo Fliser and Denis Fouque and Dimitrios Goumenos and Markus Ketteler and Ziad Massy and Ivan Rychlık and Maria Soler and Kate Stevens and Goce Spasovski and Christoph Wanner",

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year = "2019",

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doi = "10.1093/ndt/gfz023",

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Zoccali, C, Blankestijn, PJ, Bruchfeld, A, Capasso, G, Fliser, D, Fouque, D, Goumenos, D, Ketteler, M, Massy, Z, Rychlık, I, Soler, M, Stevens, K, Spasovski, G & Wanner, C 2019, 'Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials', Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, vol. 34, no. 7, pp. 1112-1114. https://doi.org/10.1093/ndt/gfz023

Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials. / Zoccali, Carmine; Blankestijn, Peter J; Bruchfeld, Annette et al.
In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 34, No. 7, 07.2019, p. 1112-1114.

Research output: Contribution to journal › Review article › peer-review

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T1 - Children of a lesser god

T2 - exclusion of chronic kidney disease patients from clinical trials

AU - Zoccali, Carmine

AU - Blankestijn, Peter J

AU - Bruchfeld, Annette

AU - Capasso, Giovambattista

AU - Fliser, Danilo

AU - Fouque, Denis

AU - Goumenos, Dimitrios

AU - Ketteler, Markus

AU - Massy, Ziad

AU - Rychlık, Ivan

AU - Soler, Maria

AU - Stevens, Kate

AU - Spasovski, Goce

AU - Wanner, Christoph

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AB - The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.

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KW - Cardiovascular

KW - Clinical trial

KW - Diabetes mellitus

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KW - guidelines

KW - diabetes mellitus

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Zoccali C, Blankestijn PJ, Bruchfeld A, Capasso G, Fliser D, Fouque D et al. Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2019 Jul;34(7):1112-1114. Epub 2019 Feb 27. doi: 10.1093/ndt/gfz023

Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials

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