Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Tesa M. Severson; Yongsoo Kim; Stacey E.P. Joosten; Karianne Schuurman; Petra Van Der Groep; Cathy B. Moelans; Natalie D. Ter Hoeve; Quirine F. Manson; John W. Martens; Carolien H.M. Van Deurzen; Ellis Barbe; Ingrid Hedenfalk; Peter Bult; Vincent T.H.B.M. Smit; Sabine C. Linn; Paul J. Van Diest; Lodewyk Wessels; Wilbert Zwart

doi:10.1038/s41467-018-02856-2

Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Tesa M. Severson, Yongsoo Kim, Stacey E.P. Joosten, Karianne Schuurman, Petra Van Der Groep, Cathy B. Moelans, Natalie D. Ter Hoeve, Quirine F. Manson, John W. Martens, Carolien H.M. Van Deurzen, Ellis Barbe, Ingrid Hedenfalk, Peter Bult, Vincent T.H.B.M. Smit, Sabine C. Linn, Paul J. Van Diest, Lodewyk Wessels, Wilbert Zwart^*

^*Corresponding author for this work

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Abstract

Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.

Original language	English
Article number	482
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-02856-2
Publication status	Published - 1 Dec 2018

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Severson, T. M., Kim, Y., Joosten, S. E. P., Schuurman, K., Van Der Groep, P., Moelans, C. B., Ter Hoeve, N. D., Manson, Q. F., Martens, J. W., Van Deurzen, C. H. M., Barbe, E., Hedenfalk, I., Bult, P., Smit, V. T. H. B. M., Linn, S. C., Van Diest, P. J., Wessels, L., & Zwart, W. (2018). Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer. Nature Communications, 9(1), Article 482. https://doi.org/10.1038/s41467-018-02856-2

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title = "Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer",

abstract = "Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.",

author = "Severson, {Tesa M.} and Yongsoo Kim and Joosten, {Stacey E.P.} and Karianne Schuurman and {Van Der Groep}, Petra and Moelans, {Cathy B.} and {Ter Hoeve}, {Natalie D.} and Manson, {Quirine F.} and Martens, {John W.} and {Van Deurzen}, {Carolien H.M.} and Ellis Barbe and Ingrid Hedenfalk and Peter Bult and Smit, {Vincent T.H.B.M.} and Linn, {Sabine C.} and {Van Diest}, {Paul J.} and Lodewyk Wessels and Wilbert Zwart",

note = "Funding Information: We thank all patients who contributed to this study. The authors would like to acknowledge all the members of hospitals that provided tumor material. Wilbert Zwart is supported by the Bas Mulder Award from the Dutch Cancer Society (KWF)/ALpe d{\textquoteright}HuZes and a VIDI grant from the Netherlands Organization for Scientific Research (NWO). JWMM received funding through the Cancer Genomics Netherlands from The Netherlands Organization for Scientific research (NWO). The authors would also like to acknowledge the effort and support of The Netherlands Cancer Institute (NKI) Genomics Core Facility. In addition, we would like to acknowledge the NKI Core Facility Molecular Pathology and Biobanking (CFMPB) for supplying Biobank material and lab support, especially Ingrid Hofland for GR IHC optimization. Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

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doi = "10.1038/s41467-018-02856-2",

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Severson, TM, Kim, Y, Joosten, SEP, Schuurman, K, Van Der Groep, P, Moelans, CB, Ter Hoeve, ND, Manson, QF, Martens, JW, Van Deurzen, CHM, Barbe, E, Hedenfalk, I, Bult, P, Smit, VTHBM, Linn, SC , Van Diest, PJ, Wessels, L & Zwart, W 2018, 'Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer', Nature Communications, vol. 9, no. 1, 482. https://doi.org/10.1038/s41467-018-02856-2

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T1 - Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

AU - Severson, Tesa M.

AU - Kim, Yongsoo

AU - Joosten, Stacey E.P.

AU - Schuurman, Karianne

AU - Van Der Groep, Petra

AU - Moelans, Cathy B.

AU - Ter Hoeve, Natalie D.

AU - Manson, Quirine F.

AU - Martens, John W.

AU - Van Deurzen, Carolien H.M.

AU - Barbe, Ellis

AU - Hedenfalk, Ingrid

AU - Bult, Peter

AU - Smit, Vincent T.H.B.M.

AU - Linn, Sabine C.

AU - Van Diest, Paul J.

AU - Wessels, Lodewyk

AU - Zwart, Wilbert

N1 - Funding Information: We thank all patients who contributed to this study. The authors would like to acknowledge all the members of hospitals that provided tumor material. Wilbert Zwart is supported by the Bas Mulder Award from the Dutch Cancer Society (KWF)/ALpe d’HuZes and a VIDI grant from the Netherlands Organization for Scientific Research (NWO). JWMM received funding through the Cancer Genomics Netherlands from The Netherlands Organization for Scientific research (NWO). The authors would also like to acknowledge the effort and support of The Netherlands Cancer Institute (NKI) Genomics Core Facility. In addition, we would like to acknowledge the NKI Core Facility Molecular Pathology and Biobanking (CFMPB) for supplying Biobank material and lab support, especially Ingrid Hofland for GR IHC optimization. Publisher Copyright: © 2018 The Author(s).

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.

AB - Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.

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SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

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