TY - JOUR
T1 - Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate
AU - Papagiannitsis, Costas C.
AU - Dolejska, Monika
AU - Izdebski, Radoslaw
AU - Dobiasova, Hana
AU - Studentova, Vendula
AU - Esteves, Francisco J.
AU - Derde, Lennie P G
AU - Bonten, Marc J M
AU - Hrabák, Jaroslav
AU - Gniadkowski, Marek
PY - 2015/8/1
Y1 - 2015/8/1
N2 - IMP-8 metallo-β-lactamase was identified in Klebsiella pneumoniae sequence type 252 (ST252), isolated in a Portuguese hospital in 2009. blaIMP-8 was the first gene cassette of a novel class 3 integron, In1144, also carrying the blaGES-5, blaBEL-1, and aacA4 cassettes. In1144 was located on a ColE1-like plasmid, pKP-M1144 (12,029 bp), with a replication region of limited nucleotide similarity to those of other RNA-priming plasmids, such as pJHCMW1. In1144 and pKP-M1144 represent an interesting case of evolution of resistance determinants in Gram-negative bacteria.
AB - IMP-8 metallo-β-lactamase was identified in Klebsiella pneumoniae sequence type 252 (ST252), isolated in a Portuguese hospital in 2009. blaIMP-8 was the first gene cassette of a novel class 3 integron, In1144, also carrying the blaGES-5, blaBEL-1, and aacA4 cassettes. In1144 was located on a ColE1-like plasmid, pKP-M1144 (12,029 bp), with a replication region of limited nucleotide similarity to those of other RNA-priming plasmids, such as pJHCMW1. In1144 and pKP-M1144 represent an interesting case of evolution of resistance determinants in Gram-negative bacteria.
UR - https://www.scopus.com/pages/publications/84939824525
U2 - 10.1128/AAC.00937-15
DO - 10.1128/AAC.00937-15
M3 - Article
AN - SCOPUS:84939824525
SN - 0066-4804
VL - 59
SP - 5065
EP - 5068
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
ER -