Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate

Costas C. Papagiannitsis; Monika Dolejska; Radoslaw Izdebski; Hana Dobiasova; Vendula Studentova; Francisco J. Esteves; Lennie P G Derde; Marc J M Bonten; Jaroslav Hrabák; Marek Gniadkowski

doi:10.1128/AAC.00937-15

Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate

Costas C. Papagiannitsis^*
, Monika Dolejska
, Radoslaw Izdebski
, Hana Dobiasova
, Vendula Studentova
, Francisco J. Esteves
, Lennie P G Derde
, Marc J M Bonten
, Jaroslav Hrabák
, Marek Gniadkowski

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

IMP-8 metallo-β-lactamase was identified in Klebsiella pneumoniae sequence type 252 (ST252), isolated in a Portuguese hospital in 2009. bla<inf>IMP-8</inf> was the first gene cassette of a novel class 3 integron, In1144, also carrying the bla<inf>GES-5</inf>, bla<inf>BEL-1</inf>, and aacA4 cassettes. In1144 was located on a ColE1-like plasmid, pKP-M1144 (12,029 bp), with a replication region of limited nucleotide similarity to those of other RNA-priming plasmids, such as pJHCMW1. In1144 and pKP-M1144 represent an interesting case of evolution of resistance determinants in Gram-negative bacteria.

Original language	English
Pages (from-to)	5065-5068
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00937-15
Publication status	Published - 1 Aug 2015

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Papagiannitsis, C. C., Dolejska, M., Izdebski, R., Dobiasova, H., Studentova, V., Esteves, F. J., Derde, L. P. G., Bonten, M. J. M., Hrabák, J., & Gniadkowski, M. (2015). Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate. Antimicrobial Agents and Chemotherapy, 59(8), 5065-5068. https://doi.org/10.1128/AAC.00937-15

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title = "Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate",

abstract = "IMP-8 metallo-β-lactamase was identified in Klebsiella pneumoniae sequence type 252 (ST252), isolated in a Portuguese hospital in 2009. blaIMP-8 was the first gene cassette of a novel class 3 integron, In1144, also carrying the blaGES-5, blaBEL-1, and aacA4 cassettes. In1144 was located on a ColE1-like plasmid, pKP-M1144 (12,029 bp), with a replication region of limited nucleotide similarity to those of other RNA-priming plasmids, such as pJHCMW1. In1144 and pKP-M1144 represent an interesting case of evolution of resistance determinants in Gram-negative bacteria.",

author = "Papagiannitsis, \{Costas C.\} and Monika Dolejska and Radoslaw Izdebski and Hana Dobiasova and Vendula Studentova and Esteves, \{Francisco J.\} and Derde, \{Lennie P G\} and Bonten, \{Marc J M\} and Jaroslav Hrab{\'a}k and Marek Gniadkowski",

year = "2015",

month = aug,

day = "1",

doi = "10.1128/AAC.00937-15",

language = "English",

volume = "59",

pages = "5065--5068",

journal = "Antimicrobial Agents and Chemotherapy",

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Papagiannitsis, CC, Dolejska, M, Izdebski, R, Dobiasova, H, Studentova, V, Esteves, FJ, Derde, LPG , Bonten, MJM, Hrabák, J & Gniadkowski, M 2015, 'Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate', Antimicrobial Agents and Chemotherapy, vol. 59, no. 8, pp. 5065-5068. https://doi.org/10.1128/AAC.00937-15

Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate. / Papagiannitsis, Costas C.; Dolejska, Monika; Izdebski, Radoslaw et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 8, 01.08.2015, p. 5065-5068.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate

AU - Papagiannitsis, Costas C.

AU - Dolejska, Monika

AU - Izdebski, Radoslaw

AU - Dobiasova, Hana

AU - Studentova, Vendula

AU - Esteves, Francisco J.

AU - Derde, Lennie P G

AU - Bonten, Marc J M

AU - Hrabák, Jaroslav

AU - Gniadkowski, Marek

PY - 2015/8/1

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AB - IMP-8 metallo-β-lactamase was identified in Klebsiella pneumoniae sequence type 252 (ST252), isolated in a Portuguese hospital in 2009. blaIMP-8 was the first gene cassette of a novel class 3 integron, In1144, also carrying the blaGES-5, blaBEL-1, and aacA4 cassettes. In1144 was located on a ColE1-like plasmid, pKP-M1144 (12,029 bp), with a replication region of limited nucleotide similarity to those of other RNA-priming plasmids, such as pJHCMW1. In1144 and pKP-M1144 represent an interesting case of evolution of resistance determinants in Gram-negative bacteria.

UR - https://www.scopus.com/pages/publications/84939824525

U2 - 10.1128/AAC.00937-15

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SN - 0066-4804

VL - 59

SP - 5065

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate

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