Characterization of atrial septal defect assessed by real-time 3-dimensional echocardiography

Annemien E van den Bosch, Derk-Jan Ten Harkel, Jackie S McGhie, Jolien W Roos-Hesselink, Maarten L Simoons, Ad J J C Bogers, Folkert J Meijboom

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVE: The aim of this study was to describe a quantitative evaluation by real-time 3-dimensional (3D) echocardiography (RT-3DE) of atrial septal defect (ASD) and atrial septum that is important for patient selection for transcatheter closure, and to assess the reliability of RT-3DE findings compared with operation.

METHODS: Forty-five patients, who were scheduled for surgical or transcatheter closure of an ASD, were included in the study.

RESULTS: In 43 patients (96%), 3D reconstructions allowed optimal imaging of the ASD. The correlations between the ASD maximal diameter by RT-3DE and operation or balloon sizing were excellent (r > 0.95). All surrounding rims of the atrial septum could be assessed on 3D reconstruction; except for the aortic rim, a cross-sectional reconstruction was created mimicking the transesophageal echocardiographic cross section (r > 0.92).

CONCLUSION: RT-3DE allows accurate determination of ASD location, ASD size, and surrounding tissue of the atrial septum, and might replace transesophageal echocardiography for patient selection for surgical or transcatheter closure.

Original languageEnglish
Pages (from-to)815-21
Number of pages7
JournalJournal of the American Society of Echocardiography
Issue number6
Publication statusPublished - Jun 2006


  • Child, Preschool
  • Computer Systems
  • Echocardiography, Three-Dimensional
  • Female
  • Heart Septal Defects, Atrial
  • Humans
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Male
  • Middle Aged
  • Prognosis
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Severity of Illness Index


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