Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

Jerome Avouac; Ulrich Walker; Alan Tyndall; André Kahan; Marco Matucci-Cerinic; Yannick Allanore; I Miniati; A Muller; F Iannone; O Distler; R Becvar; S Sierakowsky; O Kowal-Bielecka; P Coelho; J Cabane; M Cutolo; Y Shoenfeld; G Valentini; J Rovensky; G Riemekasten; P Vlachoyiannopoulos; R Caporali; S Jiri; M Inanc; I Zimmermann Gorska; P Carreira; S Novak; L Czirjak; F Oliveira Ramos; M Jendro; C Chizzolini; E J Kucharz; J Richter; F Cozzi; B Rozman; C M Mallia; A Gabrielli; D Farge; H P Kiener; D Schöffel; P Airo; F Wollheim; D Martinovic; F Trotta; S Jablonska; K Reich; S Bombardieri; P Siakka; R Pellerito; E Ton

doi:10.3899/jrheum.091165

Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

Jerome Avouac, Ulrich Walker, Alan Tyndall, André Kahan, Marco Matucci-Cerinic, Yannick Allanore, I Miniati, A Muller, F Iannone, O Distler, R Becvar, S Sierakowsky, O Kowal-Bielecka, P Coelho, J Cabane, M Cutolo, Y Shoenfeld, G Valentini, J Rovensky, G RiemekastenP Vlachoyiannopoulos, R Caporali, S Jiri, M Inanc, I Zimmermann Gorska, P Carreira, S Novak, L Czirjak, F Oliveira Ramos, M Jendro, C Chizzolini, E J Kucharz, J Richter, F Cozzi, B Rozman, C M Mallia, A Gabrielli, D Farge, H P Kiener, D Schöffel, P Airo, F Wollheim, D Martinovic, F Trotta, S Jablonska, K Reich, S Bombardieri, P Siakka, R Pellerito, E Ton,

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc).

METHODS: This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs.

RESULTS: We recruited 7286 patients with SSc; their mean age was 56 +/- 14 years, disease duration 10 +/- 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable.

CONCLUSION: Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.

Original language	English
Pages (from-to)	1488-1501
Number of pages	14
Journal	Journal of Rheumatology
Volume	37
Issue number	7
DOIs	https://doi.org/10.3899/jrheum.091165
Publication status	Published - Jul 2010

Keywords

Adult
Aged
Clinical Trials as Topic
Cross-Sectional Studies
Databases, Factual
Female
Humans
Inflammation
Joint Diseases
Joints
Male
Middle Aged
Range of Motion, Articular
Scleroderma, Localized
Scleroderma, Systemic
Synovitis
Tendons
Journal Article
Research Support, Non-U.S. Gov't

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10.3899/jrheum.091165

http://www.ncbi.nlm.nih.gov/pubmed/20551097

Cite this

Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., Miniati, I., Muller, A., Iannone, F., Distler, O., Becvar, R., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P., Cabane, J., Cutolo, M., Shoenfeld, Y., Valentini, G., Rovensky, J. (2010). Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. Journal of Rheumatology, 37(7), 1488-1501. https://doi.org/10.3899/jrheum.091165

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title = "Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database",

abstract = "OBJECTIVE: To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc).METHODS: This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs.RESULTS: We recruited 7286 patients with SSc; their mean age was 56 +/- 14 years, disease duration 10 +/- 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable.CONCLUSION: Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.",

keywords = "Adult, Aged, Clinical Trials as Topic, Cross-Sectional Studies, Databases, Factual, Female, Humans, Inflammation, Joint Diseases, Joints, Male, Middle Aged, Range of Motion, Articular, Scleroderma, Localized, Scleroderma, Systemic, Synovitis, Tendons, Journal Article, Research Support, Non-U.S. Gov't",

author = "Jerome Avouac and Ulrich Walker and Alan Tyndall and Andr{\'e} Kahan and Marco Matucci-Cerinic and Yannick Allanore and I Miniati and A Muller and F Iannone and O Distler and R Becvar and S Sierakowsky and O Kowal-Bielecka and P Coelho and J Cabane and M Cutolo and Y Shoenfeld and G Valentini and J Rovensky and G Riemekasten and P Vlachoyiannopoulos and R Caporali and S Jiri and M Inanc and {Zimmermann Gorska}, I and P Carreira and S Novak and L Czirjak and {Oliveira Ramos}, F and M Jendro and C Chizzolini and Kucharz, {E J} and J Richter and F Cozzi and B Rozman and Mallia, {C M} and A Gabrielli and D Farge and Kiener, {H P} and D Sch{\"o}ffel and P Airo and F Wollheim and D Martinovic and F Trotta and S Jablonska and K Reich and S Bombardieri and P Siakka and R Pellerito and E Ton",

year = "2010",

month = jul,

doi = "10.3899/jrheum.091165",

language = "English",

volume = "37",

pages = "1488--1501",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "7",

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Avouac, J, Walker, U, Tyndall, A, Kahan, A, Matucci-Cerinic, M, Allanore, Y, Miniati, I, Muller, A, Iannone, F, Distler, O, Becvar, R, Sierakowsky, S, Kowal-Bielecka, O, Coelho, P, Cabane, J, Cutolo, M, Shoenfeld, Y, Valentini, G, Rovensky, J, Riemekasten, G, Vlachoyiannopoulos, P, Caporali, R, Jiri, S, Inanc, M, Zimmermann Gorska, I, Carreira, P, Novak, S, Czirjak, L, Oliveira Ramos, F, Jendro, M, Chizzolini, C, Kucharz, EJ, Richter, J, Cozzi, F, Rozman, B, Mallia, CM, Gabrielli, A, Farge, D, Kiener, HP, Schöffel, D, Airo, P, Wollheim, F, Martinovic, D, Trotta, F, Jablonska, S, Reich, K, Bombardieri, S, Siakka, P, Pellerito, R, Ton, E 2010, 'Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database', Journal of Rheumatology, vol. 37, no. 7, pp. 1488-1501. https://doi.org/10.3899/jrheum.091165

Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. / Avouac, Jerome; Walker, Ulrich; Tyndall, Alan et al.
In: Journal of Rheumatology, Vol. 37, No. 7, 07.2010, p. 1488-1501.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis

T2 - results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

AU - Avouac, Jerome

AU - Walker, Ulrich

AU - Tyndall, Alan

AU - Kahan, André

AU - Matucci-Cerinic, Marco

AU - Allanore, Yannick

AU - Miniati, I

AU - Muller, A

AU - Iannone, F

AU - Distler, O

AU - Becvar, R

AU - Sierakowsky, S

AU - Kowal-Bielecka, O

AU - Coelho, P

AU - Cabane, J

AU - Cutolo, M

AU - Shoenfeld, Y

AU - Valentini, G

AU - Rovensky, J

AU - Riemekasten, G

AU - Vlachoyiannopoulos, P

AU - Caporali, R

AU - Jiri, S

AU - Inanc, M

AU - Zimmermann Gorska, I

AU - Carreira, P

AU - Novak, S

AU - Czirjak, L

AU - Oliveira Ramos, F

AU - Jendro, M

AU - Chizzolini, C

AU - Kucharz, E J

AU - Richter, J

AU - Cozzi, F

AU - Rozman, B

AU - Mallia, C M

AU - Gabrielli, A

AU - Farge, D

AU - Kiener, H P

AU - Schöffel, D

AU - Airo, P

AU - Wollheim, F

AU - Martinovic, D

AU - Trotta, F

AU - Jablonska, S

AU - Reich, K

AU - Bombardieri, S

AU - Siakka, P

AU - Pellerito, R

AU - Ton, E

PY - 2010/7

Y1 - 2010/7

N2 - OBJECTIVE: To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc).METHODS: This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs.RESULTS: We recruited 7286 patients with SSc; their mean age was 56 +/- 14 years, disease duration 10 +/- 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable.CONCLUSION: Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.

AB - OBJECTIVE: To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc).METHODS: This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs.RESULTS: We recruited 7286 patients with SSc; their mean age was 56 +/- 14 years, disease duration 10 +/- 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable.CONCLUSION: Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.

KW - Adult

KW - Aged

KW - Clinical Trials as Topic

KW - Cross-Sectional Studies

KW - Databases, Factual

KW - Female

KW - Humans

KW - Inflammation

KW - Joint Diseases

KW - Joints

KW - Male

KW - Middle Aged

KW - Range of Motion, Articular

KW - Scleroderma, Localized

KW - Scleroderma, Systemic

KW - Synovitis

KW - Tendons

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.3899/jrheum.091165

DO - 10.3899/jrheum.091165

M3 - Article

C2 - 20551097

SN - 0315-162X

VL - 37

SP - 1488

EP - 1501

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 7

ER -

Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

Abstract

Keywords

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