TY - JOUR
T1 - Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
AU - Citarella, Barbara Wanjiru
AU - Kartsonaki, Christiana
AU - Ibáñez-Prada, Elsa D.
AU - Gonçalves, Bronner P.
AU - Baruch, Joaquin
AU - Escher, Martina
AU - Pritchard, Mark G.
AU - Wei, Jia
AU - Philippy, Fred
AU - Dagens, Andrew
AU - Hall, Matthew
AU - Lee, James
AU - Kutsogiannis, Demetrios James
AU - Wils, Evert Jan
AU - Fernandes, Marília Andreia
AU - Tirupakuzhi Vijayaraghavan, Bharath Kumar
AU - Panda, Prasan Kumar
AU - Martin-Loeches, Ignacio
AU - Ohshimo, Shinichiro
AU - Fatoni, Arie Zainul
AU - Horby, Peter
AU - Dunning, Jake
AU - Rello, Jordi
AU - Merson, Laura
AU - Rojek, Amanda
AU - Vaillant, Michel
AU - Olliaro, Piero
AU - Reyes, Luis Felipe
AU - Moharam, S. A.
AU - Abdalasalam, Sabriya
AU - Abdalhadi, Alaa Abdalfattah
AU - Abdalla, Naana Reyam
AU - Abdalla, Walaa
AU - Abdalrheem, Almthani Hamza
AU - Abdalsalam, Ashraf
AU - Abdeewi, Saedah
AU - Abdelgaum, Esraa Hassan
AU - Abdelhalim, Mohamed
AU - Abdelkabir, Mohammed
AU - Abdelrahman, Israa
AU - Abdukahil, Sheryl Ann
AU - Abdulbaqi, Lamees Adil
AU - Abdulhamid, Salaheddin
AU - Bogaert, Debby
AU - Diaz, Juan Jose
AU - Khalil, Antoine
AU - Ong, David S.Y.
AU - Postma, Douwe F.
AU - van der Valk, Paul
AU - Verbon, Annelies
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/5/30
Y1 - 2024/5/30
N2 - Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders.
AB - Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders.
KW - COVID-19
KW - Mortality
KW - Non-respiratory symptoms
KW - Respiratory symptoms
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85192803986&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2024.e29591
DO - 10.1016/j.heliyon.2024.e29591
M3 - Article
AN - SCOPUS:85192803986
SN - 2405-8440
VL - 10
SP - 1
EP - 16
JO - Heliyon
JF - Heliyon
IS - 10
M1 - e29591
ER -