Changes in Pulmonary Function After Stereotactic Body Radiotherapy and After Surgery for Stage I and II Non-small Cell Lung Cancer, a Description of Two Cohorts

Leonie Alberts; SY el Sharouni; Frederik N Hofman; Bart P VAN Putte; Ellen Tromp; Marco van Vulpen; Elisabeth A Kastelijn; Franz M N H Schramel

Changes in Pulmonary Function After Stereotactic Body Radiotherapy and After Surgery for Stage I and II Non-small Cell Lung Cancer, a Description of Two Cohorts

Leonie Alberts, SY el Sharouni, Frederik N Hofman, Bart P VAN Putte, Ellen Tromp, Marco van Vulpen, Elisabeth A Kastelijn, Franz M N H Schramel

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIM: To evaluate changes in pulmonary function tests (PFTs) at different follow-up durations after stereotactic body radiotherapy (SBRT) and surgery in stage I and II non-small-cell lung cancer (NSCLC).

PATIENTS AND METHODS: Differences between pre-treatment- and follow-up PFTs were analyzed in 93 patients treated with surgery and 30 patients treated with SBRT for NSCLC. Follow-up durations were categorized into: early (0-9 months), middle (10-21 months) and late (≥22 months). Wilcoxon signed-rank test was used to analyze differences between pre-treatment and follow-up PFTs.

RESULTS: Forced expiratory volume in one second, forced vital capacity and diffusion capacity for carbon monoxide corrected for the actual hemoglobin level significantly diminished after surgery for all follow-up durations: 11-17% of predicted values. After SBRT, PFTs remained stable, but a declining trend of 6% (p=0.1) was observed after 22 months.

CONCLUSION: SBRT might lead to less treatment-related toxicity measured by PFTs than surgery in both the short and long term.

Original language	English
Pages (from-to)	6773-9
Number of pages	7
Journal	Anticancer Research
Volume	35
Issue number	12
Publication status	Published - Dec 2015

Cite this

@article{b353be2e34cf4409947b6febc93ee3b7,

title = "Changes in Pulmonary Function After Stereotactic Body Radiotherapy and After Surgery for Stage I and II Non-small Cell Lung Cancer, a Description of Two Cohorts",

abstract = "AIM: To evaluate changes in pulmonary function tests (PFTs) at different follow-up durations after stereotactic body radiotherapy (SBRT) and surgery in stage I and II non-small-cell lung cancer (NSCLC).PATIENTS AND METHODS: Differences between pre-treatment- and follow-up PFTs were analyzed in 93 patients treated with surgery and 30 patients treated with SBRT for NSCLC. Follow-up durations were categorized into: early (0-9 months), middle (10-21 months) and late (≥22 months). Wilcoxon signed-rank test was used to analyze differences between pre-treatment and follow-up PFTs.RESULTS: Forced expiratory volume in one second, forced vital capacity and diffusion capacity for carbon monoxide corrected for the actual hemoglobin level significantly diminished after surgery for all follow-up durations: 11-17\% of predicted values. After SBRT, PFTs remained stable, but a declining trend of 6\% (p=0.1) was observed after 22 months.CONCLUSION: SBRT might lead to less treatment-related toxicity measured by PFTs than surgery in both the short and long term.",

author = "Leonie Alberts and \{el Sharouni\}, SY and Hofman, \{Frederik N\} and \{VAN Putte\}, \{Bart P\} and Ellen Tromp and \{van Vulpen\}, Marco and Kastelijn, \{Elisabeth A\} and Schramel, \{Franz M N H\}",

year = "2015",

month = dec,

language = "English",

volume = "35",

pages = "6773--9",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "12",

}

TY - JOUR

T1 - Changes in Pulmonary Function After Stereotactic Body Radiotherapy and After Surgery for Stage I and II Non-small Cell Lung Cancer, a Description of Two Cohorts

AU - Alberts, Leonie

AU - el Sharouni, SY

AU - Hofman, Frederik N

AU - VAN Putte, Bart P

AU - Tromp, Ellen

AU - van Vulpen, Marco

AU - Kastelijn, Elisabeth A

AU - Schramel, Franz M N H

PY - 2015/12

Y1 - 2015/12

N2 - AIM: To evaluate changes in pulmonary function tests (PFTs) at different follow-up durations after stereotactic body radiotherapy (SBRT) and surgery in stage I and II non-small-cell lung cancer (NSCLC).PATIENTS AND METHODS: Differences between pre-treatment- and follow-up PFTs were analyzed in 93 patients treated with surgery and 30 patients treated with SBRT for NSCLC. Follow-up durations were categorized into: early (0-9 months), middle (10-21 months) and late (≥22 months). Wilcoxon signed-rank test was used to analyze differences between pre-treatment and follow-up PFTs.RESULTS: Forced expiratory volume in one second, forced vital capacity and diffusion capacity for carbon monoxide corrected for the actual hemoglobin level significantly diminished after surgery for all follow-up durations: 11-17% of predicted values. After SBRT, PFTs remained stable, but a declining trend of 6% (p=0.1) was observed after 22 months.CONCLUSION: SBRT might lead to less treatment-related toxicity measured by PFTs than surgery in both the short and long term.

AB - AIM: To evaluate changes in pulmonary function tests (PFTs) at different follow-up durations after stereotactic body radiotherapy (SBRT) and surgery in stage I and II non-small-cell lung cancer (NSCLC).PATIENTS AND METHODS: Differences between pre-treatment- and follow-up PFTs were analyzed in 93 patients treated with surgery and 30 patients treated with SBRT for NSCLC. Follow-up durations were categorized into: early (0-9 months), middle (10-21 months) and late (≥22 months). Wilcoxon signed-rank test was used to analyze differences between pre-treatment and follow-up PFTs.RESULTS: Forced expiratory volume in one second, forced vital capacity and diffusion capacity for carbon monoxide corrected for the actual hemoglobin level significantly diminished after surgery for all follow-up durations: 11-17% of predicted values. After SBRT, PFTs remained stable, but a declining trend of 6% (p=0.1) was observed after 22 months.CONCLUSION: SBRT might lead to less treatment-related toxicity measured by PFTs than surgery in both the short and long term.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26637895

M3 - Article

C2 - 26637895

SN - 0250-7005

VL - 35

SP - 6773

EP - 6779

JO - Anticancer Research

JF - Anticancer Research

IS - 12

ER -

Changes in Pulmonary Function After Stereotactic Body Radiotherapy and After Surgery for Stage I and II Non-small Cell Lung Cancer, a Description of Two Cohorts

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