TY - JOUR
T1 - Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma
AU - Schaeffers, Anouk W.M.A.
AU - Scholten, Hannah A.
AU - Kok, Annemieke
AU - Reinders, Floris C.J.
AU - Stellato, Rebecca K.
AU - Smid, Ernst J.
AU - van Beers, Maartje A.
AU - van Gils, Carla H.
AU - Speksnijder, Caroline M.
AU - Philippens, Marielle P.
AU - Devriese, Lot A.
AU - de Bree, Remco
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/6
Y1 - 2025/6
N2 - Background and purpose: The aim is to investigate whether lumbar skeletal muscle index (LSMI) decreases during treatment of head and neck squamous cell carcinoma (HNSCC) patients, and which pre-treatment variables are associated with change. Materials and methods: The LSMI before and during treatment was assessed using MRI scans of HNSCC patients treated with radiotherapy (RT) or chemoradiotherapy (CRT). Mixed models assessed LSMI change and pre-treatment covariates (i.e. age, BMI, tumor characteristics and treatment type). Results: In 63 patients the LSMI decreased from 40.56 cm2/m2 to 39.96 cm2/m2 (p trend = 0.008) on average. The LSMI of CRT patients decreased more than the LSMI of RT patients, but this was not significant (40.85–39.63 cm2/m2 vs. 40.37 to 40.19 cm2/m2; p-interaction = 0.052). No effects of pre-treatment covariates on the LSMI trend over time were observed. Conclusion: LSMI decreased during treatment in HNSCC patients, which was not related to pre-treatment variables, but seemed slightly larger for CRT patients than RT patients.
AB - Background and purpose: The aim is to investigate whether lumbar skeletal muscle index (LSMI) decreases during treatment of head and neck squamous cell carcinoma (HNSCC) patients, and which pre-treatment variables are associated with change. Materials and methods: The LSMI before and during treatment was assessed using MRI scans of HNSCC patients treated with radiotherapy (RT) or chemoradiotherapy (CRT). Mixed models assessed LSMI change and pre-treatment covariates (i.e. age, BMI, tumor characteristics and treatment type). Results: In 63 patients the LSMI decreased from 40.56 cm2/m2 to 39.96 cm2/m2 (p trend = 0.008) on average. The LSMI of CRT patients decreased more than the LSMI of RT patients, but this was not significant (40.85–39.63 cm2/m2 vs. 40.37 to 40.19 cm2/m2; p-interaction = 0.052). No effects of pre-treatment covariates on the LSMI trend over time were observed. Conclusion: LSMI decreased during treatment in HNSCC patients, which was not related to pre-treatment variables, but seemed slightly larger for CRT patients than RT patients.
KW - Change of muscle mass
KW - Chemoradiotherapy
KW - Cisplatin
KW - Head and neck oncology
KW - Skeletal muscle mass
UR - http://www.scopus.com/inward/record.url?scp=105001694000&partnerID=8YFLogxK
U2 - 10.1016/j.oor.2025.100737
DO - 10.1016/j.oor.2025.100737
M3 - Article
AN - SCOPUS:105001694000
SN - 2772-9060
VL - 14
JO - Oral Oncology Reports
JF - Oral Oncology Reports
M1 - 100737
ER -