CFTR and colorectal cancer susceptibility: an urgent need for further studies

S Spelier; S Derksen; R Hofland; J M Beekman; B Yetkin-Arik

doi:10.1016/j.trecan.2024.07.006

CFTR and colorectal cancer susceptibility: an urgent need for further studies

S Spelier, S Derksen, R Hofland, J M Beekman, B Yetkin-Arik

Research output: Contribution to journal › Short survey › peer-review

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Abstract

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.

Original language	English
Pages (from-to)	876-879
Number of pages	4
Journal	Trends in Cancer
Volume	10
Issue number	10
Early online date	14 Aug 2024
DOIs	https://doi.org/10.1016/j.trecan.2024.07.006
Publication status	Published - Oct 2024

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10.1016/j.trecan.2024.07.006Licence: CC BY-NC

PIIS2405803324001468Final published version, 525 KBLicence: CC BY-NC

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title = "CFTR and colorectal cancer susceptibility: an urgent need for further studies",

abstract = "Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.",

author = "S Spelier and S Derksen and R Hofland and Beekman, {J M} and B Yetkin-Arik",

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year = "2024",

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doi = "10.1016/j.trecan.2024.07.006",

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T1 - CFTR and colorectal cancer susceptibility

T2 - an urgent need for further studies

AU - Spelier, S

AU - Derksen, S

AU - Hofland, R

AU - Beekman, J M

AU - Yetkin-Arik, B

PY - 2024/10

Y1 - 2024/10

N2 - Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.

AB - Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.

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U2 - 10.1016/j.trecan.2024.07.006

DO - 10.1016/j.trecan.2024.07.006

M3 - Short survey

C2 - 39147661

SN - 2405-8033

VL - 10

SP - 876

EP - 879

JO - Trends in Cancer

JF - Trends in Cancer

IS - 10

ER -

CFTR and colorectal cancer susceptibility: an urgent need for further studies

Abstract

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