CFTR and colorectal cancer susceptibility: an urgent need for further studies

S Spelier, S Derksen, R Hofland, J M Beekman, B Yetkin-Arik

Research output: Contribution to journalShort surveypeer-review

Abstract

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.

Original languageEnglish
Pages (from-to)876-879
Number of pages4
JournalTrends in Cancer
Volume10
Issue number10
Early online date14 Aug 2024
DOIs
Publication statusPublished - Oct 2024

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