TY - JOUR
T1 - Cerebrovascular disease at young age is related to mother's health during the pregnancy-The Northern Finland Birth Cohort 1966 study
T2 - Cerebrovascular disease at young age is related to motherâs health during the pregnancy â the Northern Finland Birth Cohort 1966 study
AU - Rissanen, Ina
AU - Geerlings, Mirjam I
AU - Juvela, Seppo
AU - Miettunen, Jouko
AU - Paananen, Markus
AU - Tetri, Sami
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: NFBC1966 received financial support from University of Oulu (65354, 24000692); Oulu University Hospital (2/97, 8/97, 24301140); Ministry of Health and Social Affairs (23/251/97, 160/97, 190/97); National Institute for Health and Welfare (54121); and European Regional Development Fund (539/2010 A31592). This work was supported by Orion Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: NFBC1966 received financial support from University of Oulu (65354, 24000692); Oulu University Hospital (2/97, 8/97, 24301140); Ministry of Health and Social Affairs (23/251/97, 160/97, 190/97); National Institute for Health and Welfare (54121); and European Regional Development Fund (539/2010 A31592). This work was supported by Orion Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2021 World Stroke Organization.
PY - 2022/7
Y1 - 2022/7
N2 - BACKGROUND AND PURPOSE: For prevention of cerebrovascular diseases at younger age, it is important to understand the risk factors occurring early in life. We investigated the relationship between mothers' general health during pregnancy and the offspring's risk of cerebrovascular disease in age of 15 to 52 years.METHODS: Within the population-based prospective Northern Finland Birth Cohort 1966, 11,926 persons were followed from antenatal period to 52 years of age. Information on their mother's ill health conditions, i.e., hospitalizations, chronic diseases, medications, vitamin or iron supplement, fever, anemia, mood, and smoking was collected from 24th gestational week onwards. Ischemic and hemorrhagic cerebrovascular diseases of the offspring were identified from national registers in Finland. Cox proportional hazard models were used to estimate the association of mother's health conditions with incidence of cerebrovascular disease in the offspring, with adjustments for potential confounders.RESULTS: During 565,585 person-years of follow-up, 449 (2.8%) of the offspring had a cerebrovascular disease. Hospitalization during pregnancy was associated with an increased risk of cerebrovascular disease in the offspring (hazard ratio (HR) = 1.49; 95% confidence interval (CI) 1.06-2.08) after adjustment for confounders, as was having more than three ill health conditions (HR = 1.89; CI 1.14-3.11). Not using vitamin or iron supplement was associated with increased risk for cerebrovascular disease in the offspring (HR = 1.39; CI 1.01-1.89).CONCLUSIONS: The results suggest that the risk of cerebrovascular disease may start as early as during the antenatal period, and the health characteristics of mothers during pregnancy may play a role in cerebrovascular disease risk of the offspring.
AB - BACKGROUND AND PURPOSE: For prevention of cerebrovascular diseases at younger age, it is important to understand the risk factors occurring early in life. We investigated the relationship between mothers' general health during pregnancy and the offspring's risk of cerebrovascular disease in age of 15 to 52 years.METHODS: Within the population-based prospective Northern Finland Birth Cohort 1966, 11,926 persons were followed from antenatal period to 52 years of age. Information on their mother's ill health conditions, i.e., hospitalizations, chronic diseases, medications, vitamin or iron supplement, fever, anemia, mood, and smoking was collected from 24th gestational week onwards. Ischemic and hemorrhagic cerebrovascular diseases of the offspring were identified from national registers in Finland. Cox proportional hazard models were used to estimate the association of mother's health conditions with incidence of cerebrovascular disease in the offspring, with adjustments for potential confounders.RESULTS: During 565,585 person-years of follow-up, 449 (2.8%) of the offspring had a cerebrovascular disease. Hospitalization during pregnancy was associated with an increased risk of cerebrovascular disease in the offspring (hazard ratio (HR) = 1.49; 95% confidence interval (CI) 1.06-2.08) after adjustment for confounders, as was having more than three ill health conditions (HR = 1.89; CI 1.14-3.11). Not using vitamin or iron supplement was associated with increased risk for cerebrovascular disease in the offspring (HR = 1.39; CI 1.01-1.89).CONCLUSIONS: The results suggest that the risk of cerebrovascular disease may start as early as during the antenatal period, and the health characteristics of mothers during pregnancy may play a role in cerebrovascular disease risk of the offspring.
KW - birth cohort
KW - Cerebrovascular disease
KW - offspring
KW - pregnancy
KW - risk factors
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85114882442&partnerID=8YFLogxK
U2 - 10.1177/17474930211040720
DO - 10.1177/17474930211040720
M3 - Article
C2 - 34427472
SN - 1747-4930
VL - 17
SP - 681
EP - 688
JO - International Journal of Stroke
JF - International Journal of Stroke
IS - 6
ER -