Cerebrospinal Fluid Amyloid-beta Subtypes in Confirmed Frontotemporal Lobar Degeneration Cases: A Pilot Study: A Pilot Study

Nicolaas A. Verwey; Charlotte E. Teunissen; Jeroen J.M. Hoozemans; Annemieke J.M. Rozemuller; Philip Scheltens; Yolande A.L. Pijnenburg

doi:10.3233/JAD-190344

Cerebrospinal Fluid Amyloid-beta Subtypes in Confirmed Frontotemporal Lobar Degeneration Cases: A Pilot Study: A Pilot Study

Nicolaas A. Verwey^*
, Charlotte E. Teunissen
, Jeroen J.M. Hoozemans
, Annemieke J.M. Rozemuller
, Philip Scheltens
, Yolande A.L. Pijnenburg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To investigate amyloid-β (Aβ) in frontotemporal dementia (FTD), cerebrospinal fluid (CSF) Aβ38, Aβ40, and Aβ42 in frontotemporal lobar degeneration (FTLD; N = 18 genetically and/or pathologically confirmed and N = 8 FTD with concomitant amyotrophic lateral sclerosis) were compared with Alzheimer's disease (AD; pathological or Pittsburgh-compound-B Positron-emission-tomography (PIB-PET) positive; N = 25) and controls (N = 24). For all the Aβ subtypes, group difference was seen and post-hoc analysis revealed lower levels in FTLD compared to controls (p≤0.05). Aβ42/40 ratio showed no difference between FTLD and controls; however, a difference was seen between AD versus FTLD (p < 0.01). This is an intriguing finding, suggesting a possible role of Aβ in FTLD pathogenesis.

Original language	English
Pages (from-to)	15-20
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	71
Issue number	1
DOIs	https://doi.org/10.3233/JAD-190344
Publication status	Published - 1 Jan 2019
Externally published	Yes

Keywords

Alzheimer's disease
amyloid
frontotemporal dementia
frontotemporal lobar degeneration

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10.3233/JAD-190344

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title = "Cerebrospinal Fluid Amyloid-beta Subtypes in Confirmed Frontotemporal Lobar Degeneration Cases: A Pilot Study: A Pilot Study",

abstract = "To investigate amyloid-β (Aβ) in frontotemporal dementia (FTD), cerebrospinal fluid (CSF) Aβ38, Aβ40, and Aβ42 in frontotemporal lobar degeneration (FTLD; N = 18 genetically and/or pathologically confirmed and N = 8 FTD with concomitant amyotrophic lateral sclerosis) were compared with Alzheimer's disease (AD; pathological or Pittsburgh-compound-B Positron-emission-tomography (PIB-PET) positive; N = 25) and controls (N = 24). For all the Aβ subtypes, group difference was seen and post-hoc analysis revealed lower levels in FTLD compared to controls (p≤0.05). Aβ42/40 ratio showed no difference between FTLD and controls; however, a difference was seen between AD versus FTLD (p < 0.01). This is an intriguing finding, suggesting a possible role of Aβ in FTLD pathogenesis.",

keywords = "Alzheimer's disease, amyloid, frontotemporal dementia, frontotemporal lobar degeneration",

author = "Verwey, \{Nicolaas A.\} and Teunissen, \{Charlotte E.\} and Hoozemans, \{Jeroen J.M.\} and Rozemuller, \{Annemieke J.M.\} and Philip Scheltens and Pijnenburg, \{Yolande A.L.\}",

year = "2019",

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doi = "10.3233/JAD-190344",

language = "English",

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journal = "Journal of Alzheimer's Disease",

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AU - Verwey, Nicolaas A.

AU - Teunissen, Charlotte E.

AU - Hoozemans, Jeroen J.M.

AU - Rozemuller, Annemieke J.M.

AU - Scheltens, Philip

AU - Pijnenburg, Yolande A.L.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - To investigate amyloid-β (Aβ) in frontotemporal dementia (FTD), cerebrospinal fluid (CSF) Aβ38, Aβ40, and Aβ42 in frontotemporal lobar degeneration (FTLD; N = 18 genetically and/or pathologically confirmed and N = 8 FTD with concomitant amyotrophic lateral sclerosis) were compared with Alzheimer's disease (AD; pathological or Pittsburgh-compound-B Positron-emission-tomography (PIB-PET) positive; N = 25) and controls (N = 24). For all the Aβ subtypes, group difference was seen and post-hoc analysis revealed lower levels in FTLD compared to controls (p≤0.05). Aβ42/40 ratio showed no difference between FTLD and controls; however, a difference was seen between AD versus FTLD (p < 0.01). This is an intriguing finding, suggesting a possible role of Aβ in FTLD pathogenesis.

AB - To investigate amyloid-β (Aβ) in frontotemporal dementia (FTD), cerebrospinal fluid (CSF) Aβ38, Aβ40, and Aβ42 in frontotemporal lobar degeneration (FTLD; N = 18 genetically and/or pathologically confirmed and N = 8 FTD with concomitant amyotrophic lateral sclerosis) were compared with Alzheimer's disease (AD; pathological or Pittsburgh-compound-B Positron-emission-tomography (PIB-PET) positive; N = 25) and controls (N = 24). For all the Aβ subtypes, group difference was seen and post-hoc analysis revealed lower levels in FTLD compared to controls (p≤0.05). Aβ42/40 ratio showed no difference between FTLD and controls; however, a difference was seen between AD versus FTLD (p < 0.01). This is an intriguing finding, suggesting a possible role of Aβ in FTLD pathogenesis.

KW - Alzheimer's disease

KW - amyloid

KW - frontotemporal dementia

KW - frontotemporal lobar degeneration

UR - https://www.scopus.com/pages/publications/85071900358

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AN - SCOPUS:85071900358

SN - 1387-2877

VL - 71

SP - 15

EP - 20

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 1

ER -

Cerebrospinal Fluid Amyloid-beta Subtypes in Confirmed Frontotemporal Lobar Degeneration Cases: A Pilot Study: A Pilot Study

Abstract

Keywords

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