Cerebral volume measurements and subcortical white matter lesions and short-term treatment response in late life depression

Joost Janssen; Hilleke E Hulshoff Pol; Hugo G Schnack; Rob M Kok; Indrag K Lampe; Frank-Erik de Leeuw; Rene S Kahn; Thea J Heeren

doi:10.1002/gps.1790

Cerebral volume measurements and subcortical white matter lesions and short-term treatment response in late life depression

Joost Janssen, Hilleke E Hulshoff Pol, Hugo G Schnack, Rob M Kok, Indrag K Lampe, Frank-Erik de Leeuw, Rene S Kahn, Thea J Heeren

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Late life depression is associated with volumetric reductions of gray matter and increased prevalence of subcortical white matter lesions. Previous studies have shown a poorer treatment outcome in those with more severe structural brain abnormalities. In this study, quantitative and semi-quantitative magnetic resonance imaging (MRI) measures were studied in relation to response to a 12-week controlled antidepressant monotherapy trial.

METHODS: MRI (1.5 T) brain scans of 42 elderly inpatients with major depression, of which 23 were non-responder to a controlled 12-week antidepressant monotherapy trial, were acquired. In addition, clinical outcome was assessed after a one year period. Measures were volumes of global cerebral and subcortical structures.

RESULTS: After controlling for confounding, no differences were found between non-responders and responders after 12 weeks and after one year in volumes of cerebral gray and white matter, orbitofrontal cortex, hippocampus and white matter lesions.

CONCLUSIONS: Structural brain measures associated with late life depression may not be related to short-term treatment response.

Original language	English
Pages (from-to)	468-474
Number of pages	7
Journal	International Journal of Geriatric Psychiatry
Volume	22
Issue number	5
DOIs	https://doi.org/10.1002/gps.1790
Publication status	Published - 2007

Keywords

Activities of Daily Living
Aged
Aged, 80 and over
Antidepressive Agents, Second-Generation
Antidepressive Agents, Tricyclic
Brain
Cyclohexanols
Depressive Disorder, Major
Dose-Response Relationship, Drug
Double-Blind Method
Female
Follow-Up Studies
Humans
Image Processing, Computer-Assisted
Leukoaraiosis
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Fibers, Myelinated
Nortriptyline
Venlafaxine Hydrochloride
Comparative Study
Journal Article
Randomized Controlled Trial

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10.1002/gps.1790

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title = "Cerebral volume measurements and subcortical white matter lesions and short-term treatment response in late life depression",

abstract = "BACKGROUND: Late life depression is associated with volumetric reductions of gray matter and increased prevalence of subcortical white matter lesions. Previous studies have shown a poorer treatment outcome in those with more severe structural brain abnormalities. In this study, quantitative and semi-quantitative magnetic resonance imaging (MRI) measures were studied in relation to response to a 12-week controlled antidepressant monotherapy trial.METHODS: MRI (1.5 T) brain scans of 42 elderly inpatients with major depression, of which 23 were non-responder to a controlled 12-week antidepressant monotherapy trial, were acquired. In addition, clinical outcome was assessed after a one year period. Measures were volumes of global cerebral and subcortical structures.RESULTS: After controlling for confounding, no differences were found between non-responders and responders after 12 weeks and after one year in volumes of cerebral gray and white matter, orbitofrontal cortex, hippocampus and white matter lesions.CONCLUSIONS: Structural brain measures associated with late life depression may not be related to short-term treatment response.",

keywords = "Activities of Daily Living, Aged, Aged, 80 and over, Antidepressive Agents, Second-Generation, Antidepressive Agents, Tricyclic, Brain, Cyclohexanols, Depressive Disorder, Major, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Leukoaraiosis, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Nortriptyline, Venlafaxine Hydrochloride, Comparative Study, Journal Article, Randomized Controlled Trial",

author = "Joost Janssen and \{Hulshoff Pol\}, \{Hilleke E\} and Schnack, \{Hugo G\} and Kok, \{Rob M\} and Lampe, \{Indrag K\} and \{de Leeuw\}, Frank-Erik and Kahn, \{Rene S\} and Heeren, \{Thea J\}",

year = "2007",

doi = "10.1002/gps.1790",

language = "English",

volume = "22",

pages = "468--474",

journal = "International Journal of Geriatric Psychiatry",

issn = "0885-6230",

publisher = "John Wiley \& Sons Inc.",

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T1 - Cerebral volume measurements and subcortical white matter lesions and short-term treatment response in late life depression

AU - Janssen, Joost

AU - Hulshoff Pol, Hilleke E

AU - Schnack, Hugo G

AU - Kok, Rob M

AU - Lampe, Indrag K

AU - de Leeuw, Frank-Erik

AU - Kahn, Rene S

AU - Heeren, Thea J

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Late life depression is associated with volumetric reductions of gray matter and increased prevalence of subcortical white matter lesions. Previous studies have shown a poorer treatment outcome in those with more severe structural brain abnormalities. In this study, quantitative and semi-quantitative magnetic resonance imaging (MRI) measures were studied in relation to response to a 12-week controlled antidepressant monotherapy trial.METHODS: MRI (1.5 T) brain scans of 42 elderly inpatients with major depression, of which 23 were non-responder to a controlled 12-week antidepressant monotherapy trial, were acquired. In addition, clinical outcome was assessed after a one year period. Measures were volumes of global cerebral and subcortical structures.RESULTS: After controlling for confounding, no differences were found between non-responders and responders after 12 weeks and after one year in volumes of cerebral gray and white matter, orbitofrontal cortex, hippocampus and white matter lesions.CONCLUSIONS: Structural brain measures associated with late life depression may not be related to short-term treatment response.

AB - BACKGROUND: Late life depression is associated with volumetric reductions of gray matter and increased prevalence of subcortical white matter lesions. Previous studies have shown a poorer treatment outcome in those with more severe structural brain abnormalities. In this study, quantitative and semi-quantitative magnetic resonance imaging (MRI) measures were studied in relation to response to a 12-week controlled antidepressant monotherapy trial.METHODS: MRI (1.5 T) brain scans of 42 elderly inpatients with major depression, of which 23 were non-responder to a controlled 12-week antidepressant monotherapy trial, were acquired. In addition, clinical outcome was assessed after a one year period. Measures were volumes of global cerebral and subcortical structures.RESULTS: After controlling for confounding, no differences were found between non-responders and responders after 12 weeks and after one year in volumes of cerebral gray and white matter, orbitofrontal cortex, hippocampus and white matter lesions.CONCLUSIONS: Structural brain measures associated with late life depression may not be related to short-term treatment response.

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Cerebral volume measurements and subcortical white matter lesions and short-term treatment response in late life depression

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Keywords

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