Cerebral oxygenation and echocardiographic parameters in preterm neonates with a patent ductus arteriosus: An observational study

Background: A haemodynamically significant patent ductus arteriosus (hsPDA) is clinically suspected and confirmed by echocardiographic examination. A hsPDA decreases cerebral blood flow and oxygen saturation by the ductal steal phenomenon. Aim: To determine the relationship between echocardiographic parameters, cerebral oxygenation and a hsPDA in preterm infants. Methods: 380 preterm infants (2) was continuously monitored by near-infrared spectroscopy during 72 h after birth, and afterwards for at least 1 h before echocardiography. Echocardiographic parameters included ductal diameter, end-diastolic flow in the left pulmonary artery, left atrium/aorta ratio and ductal flow pattern. Results: rScO₂ was significantly related only to ductal diameter over time. Mixed modelling analysed the course of rScO₂ over time, where infants were divided into four groups: a closed duct, an open haemodynamically insignificant duct (non-sPDA), a hsPDA, which was successfully closed during study period (SC hsPDA) or a hsPDA, which was unsuccessfully closed during study period (UC hsPDA). SC hsPDA infants showed the highest rScO₂ on day 6, while UC hsPDA infants had the lowest rScO₂ values. Conclusions: Ductal diameter is the only echocardiographic parameter significantly related to cerebral oxygenation over time. Cerebral oxygenation takes a different course over time depending on the status of the duct. Low cerebral oxygenation may be suggestive of a hsPDA.