TY - JOUR
T1 - Cerebral Collateral Circulation in the Era of Reperfusion Therapies for Acute Ischemic Stroke
AU - Uniken Venema, Simone M
AU - Dankbaar, Jan Willem
AU - van der Lugt, Aad
AU - Dippel, Diederik W J
AU - van der Worp, H Bart
N1 - Funding Information:
Dr van der Lugt received research grants from the Dutch Heart Foundation, Brain Foundation Netherlands, The Netherlands Organisation for Health Research and Development, Health Holland Top Sector Life Sciences & Health; unrestricted research grants from Penumbra Inc‚ Stryker, Medtronic, Cerenovus, and Thrombolytic Science, LCC. All paid to his institution. Dr Dippel reports research grants received from the Dutch Heart Foundation, Brain Foundation Netherlands, The Netherlands Organisation for Health Research and Development, Health Holland Top Sector Life Sciences & Health; unrestricted research grants from Penumbra, Inc, Stryker, Medtronic, Cerenovus and Thrombolytic Science, LCC. All paid to his institution. Dr van der Worp is past president of the European Stroke Organisation; received research grants from the Dutch Heart Foundation, Stryker, and the European Union; advisory role for Liva Nova and Bayer. All payments were made to his institution. The other authors report no conflicts.
Funding Information:
Dr Uniken Venema performed this work as coordinator of the trial MR ASAP (Multicenter Randomized Trial of Acute Stroke Treatment in the Ambulance With a Nitroglycerin Patch), which is funded by Netherlands Cardiovascular Research Initiative, an initiative from the Dutch Heart Foundation.
Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/10
Y1 - 2022/10
N2 - Clinical outcomes of patients with acute ischemic stroke depend in part on the extent of their collateral circulation. A good collateral circulation has also been associated with greater benefit of intravenous thrombolysis and endovascular treatment. Treatment decisions for these reperfusion therapies are increasingly guided by a combination of clinical and imaging parameters, particularly in later time windows. Computed tomography and magnetic resonance imaging enable a rapid assessment of both the collateral extent and cerebral perfusion. Yet, the role of the collateral circulation in clinical decision-making is currently limited and may be underappreciated due to the use of rather coarse and rater-dependent grading methods. In this review, we discuss determinants of the collateral circulation in patients with acute ischemic stroke, report on commonly used and emerging neuroimaging techniques for assessing the collateral circulation, and discuss the therapeutic and prognostic implications of the collateral circulation in relation to reperfusion therapies for acute ischemic stroke.
AB - Clinical outcomes of patients with acute ischemic stroke depend in part on the extent of their collateral circulation. A good collateral circulation has also been associated with greater benefit of intravenous thrombolysis and endovascular treatment. Treatment decisions for these reperfusion therapies are increasingly guided by a combination of clinical and imaging parameters, particularly in later time windows. Computed tomography and magnetic resonance imaging enable a rapid assessment of both the collateral extent and cerebral perfusion. Yet, the role of the collateral circulation in clinical decision-making is currently limited and may be underappreciated due to the use of rather coarse and rater-dependent grading methods. In this review, we discuss determinants of the collateral circulation in patients with acute ischemic stroke, report on commonly used and emerging neuroimaging techniques for assessing the collateral circulation, and discuss the therapeutic and prognostic implications of the collateral circulation in relation to reperfusion therapies for acute ischemic stroke.
KW - Brain Ischemia/diagnostic imaging
KW - Cerebrovascular Circulation
KW - Collateral Circulation
KW - Humans
KW - Ischemic Stroke
KW - Reperfusion
KW - Stroke/diagnostic imaging
KW - magnetic resonance imaging
KW - tomography
KW - collateral circulation
KW - reperfusion
KW - ischemic stroke
UR - https://www.scopus.com/pages/publications/85138487103
U2 - 10.1161/STROKEAHA.121.037869
DO - 10.1161/STROKEAHA.121.037869
M3 - Review article
C2 - 35938420
SN - 0039-2499
VL - 53
SP - 3222
EP - 3234
JO - Stroke
JF - Stroke
IS - 10
ER -