Central Nervous System Progression in Primary Vitreoretinal Lymphoma with Bilateral and Unilateral Involvement: A Systematic Review and Meta-Analysis

Josephus L M van Rooij; Klaudia A Tokarska; Ninette H Ten Dam-van Loon; Peter H Wessels; Tatjana Seute; Monique C Minnema; Tom J Snijders

doi:10.3390/cancers14122967

Central Nervous System Progression in Primary Vitreoretinal Lymphoma with Bilateral and Unilateral Involvement: A Systematic Review and Meta-Analysis

Josephus L M van Rooij, Klaudia A Tokarska, Ninette H Ten Dam-van Loon, Peter H Wessels, Tatjana Seute, Monique C Minnema, Tom J Snijders

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Abstract

BACKGROUND: Primary vitreoretinal lymphoma (PVRL) is either unilateral or bilateral at initial presentation. Progression to a central nervous system (CNS) lymphoma is regularly observed and these patients seem to have an inferior survival. Knowledge of the predictive value of laterality for CNS progression may facilitate risk stratification and the development of more effective treatment strategies, and eventually, improve outcomes. The objective of this analysis is to estimate the risk of CNS progression for patients with bilateral versus unilateral involvement of PVRL.

METHODS: Systematic literature search for studies on CNS progression in PVRL with bilateral and unilateral involvement according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We assessed the risk of bias and the methodological quality of studies using the Quality in Prognosis Studies (QUIPS) tool. Risk ratios of CNS progression in PVRL with bilateral and unilateral involvement were calculated and combined via a meta-analysis.

RESULTS: Twenty-five small-sized (total n = 371 cases) studies were included. The majority of the studies were at medium to high risk of bias. Results suggest no significant difference in CNS progression between bilateral and unilateral PVRL, with a pooled relative risk ratio of 1.12 (95% confidence interval 0.89-1.41).

CONCLUSIONS: CNS progression is common in PVRL. From the limited available evidence, there is no significant difference in CNS progression between bilateral and unilateral PVRL.

Original language	English
Article number	2967
Pages (from-to)	1-14
Journal	Cancers
Volume	14
Issue number	12
DOIs	https://doi.org/10.3390/cancers14122967
Publication status	Published - 16 Jun 2022

Keywords

CNS involvement
neuro-oncology
ophthalmology
primary central nervous system lymphoma
primary intraocular lymphoma
primary vitreoretinal lymphoma

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10.3390/cancers14122967Licence: CC BY

cancers-14-02967Final published version, 1.08 MBLicence: CC BY

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@article{9db55408a30d488db123869d4fe364f4,

title = "Central Nervous System Progression in Primary Vitreoretinal Lymphoma with Bilateral and Unilateral Involvement: A Systematic Review and Meta-Analysis",

abstract = "BACKGROUND: Primary vitreoretinal lymphoma (PVRL) is either unilateral or bilateral at initial presentation. Progression to a central nervous system (CNS) lymphoma is regularly observed and these patients seem to have an inferior survival. Knowledge of the predictive value of laterality for CNS progression may facilitate risk stratification and the development of more effective treatment strategies, and eventually, improve outcomes. The objective of this analysis is to estimate the risk of CNS progression for patients with bilateral versus unilateral involvement of PVRL.METHODS: Systematic literature search for studies on CNS progression in PVRL with bilateral and unilateral involvement according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We assessed the risk of bias and the methodological quality of studies using the Quality in Prognosis Studies (QUIPS) tool. Risk ratios of CNS progression in PVRL with bilateral and unilateral involvement were calculated and combined via a meta-analysis.RESULTS: Twenty-five small-sized (total n = 371 cases) studies were included. The majority of the studies were at medium to high risk of bias. Results suggest no significant difference in CNS progression between bilateral and unilateral PVRL, with a pooled relative risk ratio of 1.12 (95% confidence interval 0.89-1.41). CONCLUSIONS: CNS progression is common in PVRL. From the limited available evidence, there is no significant difference in CNS progression between bilateral and unilateral PVRL.",

keywords = "CNS involvement, neuro-oncology, ophthalmology, primary central nervous system lymphoma, primary intraocular lymphoma, primary vitreoretinal lymphoma",

author = "{van Rooij}, {Josephus L M} and Tokarska, {Klaudia A} and {Ten Dam-van Loon}, {Ninette H} and Wessels, {Peter H} and Tatjana Seute and Minnema, {Monique C} and Snijders, {Tom J}",

note = "Funding Information: Funding: This research was funded by the Stichting Annie van Koeverden. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "16",

doi = "10.3390/cancers14122967",

language = "English",

volume = "14",

pages = "1--14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

TY - JOUR

T1 - Central Nervous System Progression in Primary Vitreoretinal Lymphoma with Bilateral and Unilateral Involvement

T2 - A Systematic Review and Meta-Analysis

AU - van Rooij, Josephus L M

AU - Tokarska, Klaudia A

AU - Ten Dam-van Loon, Ninette H

AU - Wessels, Peter H

AU - Seute, Tatjana

AU - Minnema, Monique C

AU - Snijders, Tom J

PY - 2022/6/16

Y1 - 2022/6/16

N2 - BACKGROUND: Primary vitreoretinal lymphoma (PVRL) is either unilateral or bilateral at initial presentation. Progression to a central nervous system (CNS) lymphoma is regularly observed and these patients seem to have an inferior survival. Knowledge of the predictive value of laterality for CNS progression may facilitate risk stratification and the development of more effective treatment strategies, and eventually, improve outcomes. The objective of this analysis is to estimate the risk of CNS progression for patients with bilateral versus unilateral involvement of PVRL.METHODS: Systematic literature search for studies on CNS progression in PVRL with bilateral and unilateral involvement according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We assessed the risk of bias and the methodological quality of studies using the Quality in Prognosis Studies (QUIPS) tool. Risk ratios of CNS progression in PVRL with bilateral and unilateral involvement were calculated and combined via a meta-analysis.RESULTS: Twenty-five small-sized (total n = 371 cases) studies were included. The majority of the studies were at medium to high risk of bias. Results suggest no significant difference in CNS progression between bilateral and unilateral PVRL, with a pooled relative risk ratio of 1.12 (95% confidence interval 0.89-1.41). CONCLUSIONS: CNS progression is common in PVRL. From the limited available evidence, there is no significant difference in CNS progression between bilateral and unilateral PVRL.

AB - BACKGROUND: Primary vitreoretinal lymphoma (PVRL) is either unilateral or bilateral at initial presentation. Progression to a central nervous system (CNS) lymphoma is regularly observed and these patients seem to have an inferior survival. Knowledge of the predictive value of laterality for CNS progression may facilitate risk stratification and the development of more effective treatment strategies, and eventually, improve outcomes. The objective of this analysis is to estimate the risk of CNS progression for patients with bilateral versus unilateral involvement of PVRL.METHODS: Systematic literature search for studies on CNS progression in PVRL with bilateral and unilateral involvement according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We assessed the risk of bias and the methodological quality of studies using the Quality in Prognosis Studies (QUIPS) tool. Risk ratios of CNS progression in PVRL with bilateral and unilateral involvement were calculated and combined via a meta-analysis.RESULTS: Twenty-five small-sized (total n = 371 cases) studies were included. The majority of the studies were at medium to high risk of bias. Results suggest no significant difference in CNS progression between bilateral and unilateral PVRL, with a pooled relative risk ratio of 1.12 (95% confidence interval 0.89-1.41). CONCLUSIONS: CNS progression is common in PVRL. From the limited available evidence, there is no significant difference in CNS progression between bilateral and unilateral PVRL.

KW - CNS involvement

KW - neuro-oncology

KW - ophthalmology

KW - primary central nervous system lymphoma

KW - primary intraocular lymphoma

KW - primary vitreoretinal lymphoma

UR - http://www.scopus.com/inward/record.url?scp=85132044924&partnerID=8YFLogxK

U2 - 10.3390/cancers14122967

DO - 10.3390/cancers14122967

M3 - Review article

C2 - 35740632

SN - 2072-6694

VL - 14

SP - 1

EP - 14

JO - Cancers

JF - Cancers

IS - 12

M1 - 2967

ER -

Central Nervous System Progression in Primary Vitreoretinal Lymphoma with Bilateral and Unilateral Involvement: A Systematic Review and Meta-Analysis

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