TY - JOUR
T1 - Cellular polyploidy in organ homeostasis and regeneration
AU - Fang, Juntao
AU - de Bruin, Alain
AU - Villunger, Andreas
AU - Schiffelers, Raymond
AU - Lei, Zhiyong
AU - Sluijter, Joost P G
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.
AB - Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.
KW - cardiac regeneration
KW - cellular polyploidy
KW - liver regeneration
KW - tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=85166395118&partnerID=8YFLogxK
U2 - 10.1093/procel/pwac064
DO - 10.1093/procel/pwac064
M3 - Article
C2 - 37526344
SN - 1674-800X
VL - 14
SP - 560
EP - 578
JO - Protein & cell
JF - Protein & cell
IS - 8
ER -