Cellular and humoral responses to tetanus vaccination in gabonese children

E. van Riet; K. Retra; A. A. Adegnika; C. M. Jol-van der Zijde; B. Lell; S. Issifou; P. G. Kremsner; M. Yazdanbakhsh; M. J.D. van Tol; F. C. Hartgers

doi:10.1016/j.vaccine.2008.04.067

Cellular and humoral responses to tetanus vaccination in gabonese children

E. van Riet^*, K. Retra, A. A. Adegnika, C. M. Jol-van der Zijde, B. Lell, S. Issifou, P. G. Kremsner, M. Yazdanbakhsh, M. J.D. van Tol, F. C. Hartgers

^*Corresponding author for this work

Julius Center, dept. General Practice & Nursing Science

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Abstract

Protection to tetanus is often not optimal in developing countries due to incomplete vaccination schemes, or decreased efficacy of vaccination. In this study we investigated the immunological response to tetanus booster vaccination in school children living in a semi-urban or in a rural area of Gabon. Tetanus-specific total IgG as well as antibody subclasses of the IgG1, IgG2, IgG3 and IgG4 isotype and the avidity of the dominating IgG1 subclass were determined both before and 1 month after the booster vaccination. In addition, tetanus-specific cytokine responses were determined. We found a polarization towards a T helper 1 (Th1) profile in the semi-urban children, whereas the cytokine responses of the rural children showed a T helper 2 (Th2) skewed response. Furthermore, tetanus-specific antibodies of the different IgG subclasses were all increased upon a tetanus booster vaccination and levels of IgG1 and IgG3 were higher in the rural children. In conclusion, a tetanus booster vaccination induced a stronger Th2 over Th1 cytokine profile to tetanus toxoid (TT) in rural children who showed the highest levels of IgG1 and IgG3 anti-TT antibody responses.

Original language	English
Pages (from-to)	3690-3695
Number of pages	6
Journal	Vaccine
Volume	26
Issue number	29-30
DOIs	https://doi.org/10.1016/j.vaccine.2008.04.067
Publication status	Published - 4 Jul 2008

Keywords

Rural/semi-urban
Tetanus
Vaccination

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10.1016/j.vaccine.2008.04.067

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title = "Cellular and humoral responses to tetanus vaccination in gabonese children",

abstract = "Protection to tetanus is often not optimal in developing countries due to incomplete vaccination schemes, or decreased efficacy of vaccination. In this study we investigated the immunological response to tetanus booster vaccination in school children living in a semi-urban or in a rural area of Gabon. Tetanus-specific total IgG as well as antibody subclasses of the IgG1, IgG2, IgG3 and IgG4 isotype and the avidity of the dominating IgG1 subclass were determined both before and 1 month after the booster vaccination. In addition, tetanus-specific cytokine responses were determined. We found a polarization towards a T helper 1 (Th1) profile in the semi-urban children, whereas the cytokine responses of the rural children showed a T helper 2 (Th2) skewed response. Furthermore, tetanus-specific antibodies of the different IgG subclasses were all increased upon a tetanus booster vaccination and levels of IgG1 and IgG3 were higher in the rural children. In conclusion, a tetanus booster vaccination induced a stronger Th2 over Th1 cytokine profile to tetanus toxoid (TT) in rural children who showed the highest levels of IgG1 and IgG3 anti-TT antibody responses.",

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AU - van Riet, E.

AU - Retra, K.

AU - Adegnika, A. A.

AU - Jol-van der Zijde, C. M.

AU - Lell, B.

AU - Issifou, S.

AU - Kremsner, P. G.

AU - Yazdanbakhsh, M.

AU - van Tol, M. J.D.

AU - Hartgers, F. C.

PY - 2008/7/4

Y1 - 2008/7/4

N2 - Protection to tetanus is often not optimal in developing countries due to incomplete vaccination schemes, or decreased efficacy of vaccination. In this study we investigated the immunological response to tetanus booster vaccination in school children living in a semi-urban or in a rural area of Gabon. Tetanus-specific total IgG as well as antibody subclasses of the IgG1, IgG2, IgG3 and IgG4 isotype and the avidity of the dominating IgG1 subclass were determined both before and 1 month after the booster vaccination. In addition, tetanus-specific cytokine responses were determined. We found a polarization towards a T helper 1 (Th1) profile in the semi-urban children, whereas the cytokine responses of the rural children showed a T helper 2 (Th2) skewed response. Furthermore, tetanus-specific antibodies of the different IgG subclasses were all increased upon a tetanus booster vaccination and levels of IgG1 and IgG3 were higher in the rural children. In conclusion, a tetanus booster vaccination induced a stronger Th2 over Th1 cytokine profile to tetanus toxoid (TT) in rural children who showed the highest levels of IgG1 and IgG3 anti-TT antibody responses.

AB - Protection to tetanus is often not optimal in developing countries due to incomplete vaccination schemes, or decreased efficacy of vaccination. In this study we investigated the immunological response to tetanus booster vaccination in school children living in a semi-urban or in a rural area of Gabon. Tetanus-specific total IgG as well as antibody subclasses of the IgG1, IgG2, IgG3 and IgG4 isotype and the avidity of the dominating IgG1 subclass were determined both before and 1 month after the booster vaccination. In addition, tetanus-specific cytokine responses were determined. We found a polarization towards a T helper 1 (Th1) profile in the semi-urban children, whereas the cytokine responses of the rural children showed a T helper 2 (Th2) skewed response. Furthermore, tetanus-specific antibodies of the different IgG subclasses were all increased upon a tetanus booster vaccination and levels of IgG1 and IgG3 were higher in the rural children. In conclusion, a tetanus booster vaccination induced a stronger Th2 over Th1 cytokine profile to tetanus toxoid (TT) in rural children who showed the highest levels of IgG1 and IgG3 anti-TT antibody responses.

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ER -

Cellular and humoral responses to tetanus vaccination in gabonese children

Abstract

Keywords

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