TY - JOUR
T1 - Cell-mediated cytotoxicity patterns of coloned cytotoxic t lymphocytes
T2 - Cytotoxicity directed against canine lymphoblasts, monocytes, and endothelial cells
AU - Groenewegen, G.
AU - Buurman, W. A.
AU - Van Der Linden, C. J.
AU - Jeunhomme, G. M.A.A.
AU - Kootstra, G.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Knowledge of the antigens recognized during allograft rejection is still incomplete. Cloned cytotoxic T lymphocytes were used to study the distribution of target determinants in the dog. CTL clones were obtained with a limiting dilution technique from effector cells generated in mixed lymphocyte culture. The clones have been tested for cell-mediated cytotoxicity against PHA-stimulated lymphoblasts, monocytes, and arterial and venous endothelial cells. A limited number of patterns of lysis of one, or more than one, of the four different target cells was observed. The nature of the possible target determinants recognized by these CTL-clones is discussed.
AB - Knowledge of the antigens recognized during allograft rejection is still incomplete. Cloned cytotoxic T lymphocytes were used to study the distribution of target determinants in the dog. CTL clones were obtained with a limiting dilution technique from effector cells generated in mixed lymphocyte culture. The clones have been tested for cell-mediated cytotoxicity against PHA-stimulated lymphoblasts, monocytes, and arterial and venous endothelial cells. A limited number of patterns of lysis of one, or more than one, of the four different target cells was observed. The nature of the possible target determinants recognized by these CTL-clones is discussed.
UR - https://www.scopus.com/pages/publications/0021813918
U2 - 10.1097/00007890-198506000-00016
DO - 10.1097/00007890-198506000-00016
M3 - Article
C2 - 2408367
AN - SCOPUS:0021813918
SN - 0041-1337
VL - 39
SP - 657
EP - 660
JO - Transplantation
JF - Transplantation
IS - 6
ER -