CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: A multinational, multicohort European study

Linda Wittkop; Julie Arsandaux; Ana Trevino; Maarten Schim van der Loeff; Jane Anderson; Ard van Sighem; Jürg Böni; Françoise Brun-Vezinet; Vicente Soriano; Faroudy Boufassa; Norbert Brockmeyer; Alexandra Calmy; François Dabis; Inma Jarrin; Maria Dorrucci; Vitor Duque; Gerd Fätkenheuer; Robert Zangerle; Elena Ferrer; Kholoud Porter; Ali Judd; Nikolaos V. Sipsas; Olivier Lambotte; Leah Shepherd; Catherine Leport; Charles Morrison; Cristina Mussini; Niels Obel; Jean Ruelle; Carolyne Schwarze-Zander; Anders Sonnerborg; Ramon Teira; Carlo Torti; Emilia Valadas; Celine Colin; Nina Friis-Møller; Dominique Costagliola; Rodolphe Thiebaut; Geneviève Chene; Sophie Matheron; Giota Touloumi; Josiane Warszawski; Laurence Meyer; Murielle Mary Krause; Jade Ghosn; Peter Reiss; Ferdinand Wit; Maria Prins; Heiner Bucher; Marc van der Valk

doi:10.1093/jac/dkx210

CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: A multinational, multicohort European study

Linda Wittkop^*, Julie Arsandaux, Ana Trevino, Maarten Schim van der Loeff, Jane Anderson, Ard van Sighem, Jürg Böni, Françoise Brun-Vezinet, Vicente Soriano, Faroudy Boufassa, Norbert Brockmeyer, Alexandra Calmy, François Dabis, Inma Jarrin, Maria Dorrucci, Vitor Duque, Gerd Fätkenheuer, Robert Zangerle, Elena Ferrer, Kholoud PorterAli Judd, Nikolaos V. Sipsas, Olivier Lambotte, Leah Shepherd, Catherine Leport, Charles Morrison, Cristina Mussini, Niels Obel, Jean Ruelle, Carolyne Schwarze-Zander, Anders Sonnerborg, Ramon Teira, Carlo Torti, Emilia Valadas, Celine Colin, Nina Friis-Møller, Dominique Costagliola, Rodolphe Thiebaut, Geneviève Chene, Sophie Matheron, Giota Touloumi, Josiane Warszawski, Laurence Meyer, Murielle Mary Krause, Jade Ghosn, Peter Reiss, Ferdinand Wit, Maria Prins, Heiner Bucher, Marc van der Valk,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: CD4 cell recovery following first-line combination ART (cART) is poorer in HIV-2+ than in HIV-1+ patients. Only large comparisons may allow adjustments for demographic and pretreatment plasma viral load (pVL). Methods: ART-naive HIV+ adults from two European multicohort collaborations, COHERE (HIV-1 alone) and ACHIeV2e (HIV-2 alone), were included, if they started first-line cART (without NNRTIs or fusion inhibitors) between 1997 and 2011. Patients without at least one CD4 cell count before start of cART, without a pretreatment pVL and with missing a priori-defined covariables were excluded. Evolution of CD4 cell count was studied using adjusted linear mixed models. Results: We included 185 HIV-2+ and 30321 HIV-1+ patients with median age of 46 years (IQR 36-52) and 37 years (IQR 31-44), respectively. Median observed pretreatment CD4 cell counts/mm3 were 203 (95% CI 100-290) in HIV-2+ patients and 223 (95% CI 100-353) in HIV-1+ patients. Mean observed CD4 cell count changes from start of cART to 12months were +105 (95% CI 77-134) in HIV-2+ patients and +202 (95% CI 199-205) in HIV-1+ patients, an observed difference of 97 cells/mm³ in 1 year. In adjusted analysis, the mean CD4 cell increase was overall 25 CD4 cells/mm³/year lower (95% CI 5-44; P=0.0127) in HIV-2+ patients compared with HIV-1+ patients. Conclusions: A poorer CD4 cell increase during first-line cART was observed in HIV-2+patients, even after adjusting for pretreatment pVL and other potential confounders. Our results underline the need to identify more potent therapeutic regimens or strategies against HIV-2.

Original language	English
Pages (from-to)	2869-2878
Number of pages	10
Journal	Journal of Antimicrobial Chemotherapy
Volume	72
Issue number	10
DOIs	https://doi.org/10.1093/jac/dkx210
Publication status	Published - Oct 2017

Keywords

Adult
Anti-HIV Agents/administration & dosage
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes/immunology
Cohort Studies
Europe
Female
HIV Infections/blood
HIV-1/drug effects
HIV-2/drug effects
Humans
Internationality
Male
Middle Aged
RNA, Viral/blood
Viral Load

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10.1093/jac/dkx210

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Wittkop, L., Arsandaux, J., Trevino, A., van der Loeff, M. S., Anderson, J., van Sighem, A., Böni, J., Brun-Vezinet, F., Soriano, V., Boufassa, F., Brockmeyer, N., Calmy, A., Dabis, F., Jarrin, I., Dorrucci, M., Duque, V., Fätkenheuer, G., Zangerle, R., Ferrer, E. (2017). CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: A multinational, multicohort European study. Journal of Antimicrobial Chemotherapy, 72(10), 2869-2878. https://doi.org/10.1093/jac/dkx210

@article{7c3ef78242c34525ba727b709b24b26b,

title = "CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: A multinational, multicohort European study",

abstract = "Background: CD4 cell recovery following first-line combination ART (cART) is poorer in HIV-2+ than in HIV-1+ patients. Only large comparisons may allow adjustments for demographic and pretreatment plasma viral load (pVL). Methods: ART-naive HIV+ adults from two European multicohort collaborations, COHERE (HIV-1 alone) and ACHIeV2e (HIV-2 alone), were included, if they started first-line cART (without NNRTIs or fusion inhibitors) between 1997 and 2011. Patients without at least one CD4 cell count before start of cART, without a pretreatment pVL and with missing a priori-defined covariables were excluded. Evolution of CD4 cell count was studied using adjusted linear mixed models. Results: We included 185 HIV-2+ and 30321 HIV-1+ patients with median age of 46 years (IQR 36-52) and 37 years (IQR 31-44), respectively. Median observed pretreatment CD4 cell counts/mm3 were 203 (95\% CI 100-290) in HIV-2+ patients and 223 (95\% CI 100-353) in HIV-1+ patients. Mean observed CD4 cell count changes from start of cART to 12months were +105 (95\% CI 77-134) in HIV-2+ patients and +202 (95\% CI 199-205) in HIV-1+ patients, an observed difference of 97 cells/mm3 in 1 year. In adjusted analysis, the mean CD4 cell increase was overall 25 CD4 cells/mm3/year lower (95\% CI 5-44; P=0.0127) in HIV-2+ patients compared with HIV-1+ patients. Conclusions: A poorer CD4 cell increase during first-line cART was observed in HIV-2+patients, even after adjusting for pretreatment pVL and other potential confounders. Our results underline the need to identify more potent therapeutic regimens or strategies against HIV-2.",

keywords = "Adult, Anti-HIV Agents/administration \& dosage, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes/immunology, Cohort Studies, Europe, Female, HIV Infections/blood, HIV-1/drug effects, HIV-2/drug effects, Humans, Internationality, Male, Middle Aged, RNA, Viral/blood, Viral Load",

author = "Linda Wittkop and Julie Arsandaux and Ana Trevino and \{van der Loeff\}, \{Maarten Schim\} and Jane Anderson and \{van Sighem\}, Ard and J{\"u}rg B{\"o}ni and Fran{\c c}oise Brun-Vezinet and Vicente Soriano and Faroudy Boufassa and Norbert Brockmeyer and Alexandra Calmy and Fran{\c c}ois Dabis and Inma Jarrin and Maria Dorrucci and Vitor Duque and Gerd F{\"a}tkenheuer and Robert Zangerle and Elena Ferrer and Kholoud Porter and Ali Judd and Sipsas, \{Nikolaos V.\} and Olivier Lambotte and Leah Shepherd and Catherine Leport and Charles Morrison and Cristina Mussini and Niels Obel and Jean Ruelle and Carolyne Schwarze-Zander and Anders Sonnerborg and Ramon Teira and Carlo Torti and Emilia Valadas and Celine Colin and Nina Friis-M{\o}ller and Dominique Costagliola and Rodolphe Thiebaut and Genevi{\`e}ve Chene and Sophie Matheron and Giota Touloumi and Josiane Warszawski and Laurence Meyer and Krause, \{Murielle Mary\} and Jade Ghosn and Peter Reiss and Ferdinand Wit and Maria Prins and Heiner Bucher and \{van der Valk\}, Marc and Andy Hoepelman",

year = "2017",

month = oct,

doi = "10.1093/jac/dkx210",

language = "English",

volume = "72",

pages = "2869--2878",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "10",

}

Wittkop, L, Arsandaux, J, Trevino, A, van der Loeff, MS, Anderson, J, van Sighem, A, Böni, J, Brun-Vezinet, F, Soriano, V, Boufassa, F, Brockmeyer, N, Calmy, A, Dabis, F, Jarrin, I, Dorrucci, M, Duque, V, Fätkenheuer, G, Zangerle, R, Ferrer, E, Porter, K, Judd, A, Sipsas, NV, Lambotte, O, Shepherd, L, Leport, C, Morrison, C, Mussini, C, Obel, N, Ruelle, J, Schwarze-Zander, C, Sonnerborg, A, Teira, R, Torti, C, Valadas, E, Colin, C, Friis-Møller, N, Costagliola, D, Thiebaut, R, Chene, G, Matheron, S, Touloumi, G, Warszawski, J, Meyer, L, Krause, MM, Ghosn, J, Reiss, P, Wit, F, Prins, M, Bucher, H, van der Valk, M 2017, 'CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: A multinational, multicohort European study', Journal of Antimicrobial Chemotherapy, vol. 72, no. 10, pp. 2869-2878. https://doi.org/10.1093/jac/dkx210

TY - JOUR

T1 - CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients

T2 - A multinational, multicohort European study

AU - Wittkop, Linda

AU - Arsandaux, Julie

AU - Trevino, Ana

AU - van der Loeff, Maarten Schim

AU - Anderson, Jane

AU - van Sighem, Ard

AU - Böni, Jürg

AU - Brun-Vezinet, Françoise

AU - Soriano, Vicente

AU - Boufassa, Faroudy

AU - Brockmeyer, Norbert

AU - Calmy, Alexandra

AU - Dabis, François

AU - Jarrin, Inma

AU - Dorrucci, Maria

AU - Duque, Vitor

AU - Fätkenheuer, Gerd

AU - Zangerle, Robert

AU - Ferrer, Elena

AU - Porter, Kholoud

AU - Judd, Ali

AU - Sipsas, Nikolaos V.

AU - Lambotte, Olivier

AU - Shepherd, Leah

AU - Leport, Catherine

AU - Morrison, Charles

AU - Mussini, Cristina

AU - Obel, Niels

AU - Ruelle, Jean

AU - Schwarze-Zander, Carolyne

AU - Sonnerborg, Anders

AU - Teira, Ramon

AU - Torti, Carlo

AU - Valadas, Emilia

AU - Colin, Celine

AU - Friis-Møller, Nina

AU - Costagliola, Dominique

AU - Thiebaut, Rodolphe

AU - Chene, Geneviève

AU - Matheron, Sophie

AU - Touloumi, Giota

AU - Warszawski, Josiane

AU - Meyer, Laurence

AU - Krause, Murielle Mary

AU - Ghosn, Jade

AU - Reiss, Peter

AU - Wit, Ferdinand

AU - Prins, Maria

AU - Bucher, Heiner

AU - van der Valk, Marc

AU - Hoepelman, Andy

PY - 2017/10

Y1 - 2017/10

N2 - Background: CD4 cell recovery following first-line combination ART (cART) is poorer in HIV-2+ than in HIV-1+ patients. Only large comparisons may allow adjustments for demographic and pretreatment plasma viral load (pVL). Methods: ART-naive HIV+ adults from two European multicohort collaborations, COHERE (HIV-1 alone) and ACHIeV2e (HIV-2 alone), were included, if they started first-line cART (without NNRTIs or fusion inhibitors) between 1997 and 2011. Patients without at least one CD4 cell count before start of cART, without a pretreatment pVL and with missing a priori-defined covariables were excluded. Evolution of CD4 cell count was studied using adjusted linear mixed models. Results: We included 185 HIV-2+ and 30321 HIV-1+ patients with median age of 46 years (IQR 36-52) and 37 years (IQR 31-44), respectively. Median observed pretreatment CD4 cell counts/mm3 were 203 (95% CI 100-290) in HIV-2+ patients and 223 (95% CI 100-353) in HIV-1+ patients. Mean observed CD4 cell count changes from start of cART to 12months were +105 (95% CI 77-134) in HIV-2+ patients and +202 (95% CI 199-205) in HIV-1+ patients, an observed difference of 97 cells/mm3 in 1 year. In adjusted analysis, the mean CD4 cell increase was overall 25 CD4 cells/mm3/year lower (95% CI 5-44; P=0.0127) in HIV-2+ patients compared with HIV-1+ patients. Conclusions: A poorer CD4 cell increase during first-line cART was observed in HIV-2+patients, even after adjusting for pretreatment pVL and other potential confounders. Our results underline the need to identify more potent therapeutic regimens or strategies against HIV-2.

AB - Background: CD4 cell recovery following first-line combination ART (cART) is poorer in HIV-2+ than in HIV-1+ patients. Only large comparisons may allow adjustments for demographic and pretreatment plasma viral load (pVL). Methods: ART-naive HIV+ adults from two European multicohort collaborations, COHERE (HIV-1 alone) and ACHIeV2e (HIV-2 alone), were included, if they started first-line cART (without NNRTIs or fusion inhibitors) between 1997 and 2011. Patients without at least one CD4 cell count before start of cART, without a pretreatment pVL and with missing a priori-defined covariables were excluded. Evolution of CD4 cell count was studied using adjusted linear mixed models. Results: We included 185 HIV-2+ and 30321 HIV-1+ patients with median age of 46 years (IQR 36-52) and 37 years (IQR 31-44), respectively. Median observed pretreatment CD4 cell counts/mm3 were 203 (95% CI 100-290) in HIV-2+ patients and 223 (95% CI 100-353) in HIV-1+ patients. Mean observed CD4 cell count changes from start of cART to 12months were +105 (95% CI 77-134) in HIV-2+ patients and +202 (95% CI 199-205) in HIV-1+ patients, an observed difference of 97 cells/mm3 in 1 year. In adjusted analysis, the mean CD4 cell increase was overall 25 CD4 cells/mm3/year lower (95% CI 5-44; P=0.0127) in HIV-2+ patients compared with HIV-1+ patients. Conclusions: A poorer CD4 cell increase during first-line cART was observed in HIV-2+patients, even after adjusting for pretreatment pVL and other potential confounders. Our results underline the need to identify more potent therapeutic regimens or strategies against HIV-2.

KW - Adult

KW - Anti-HIV Agents/administration & dosage

KW - CD4 Lymphocyte Count

KW - CD4-Positive T-Lymphocytes/immunology

KW - Cohort Studies

KW - Europe

KW - Female

KW - HIV Infections/blood

KW - HIV-1/drug effects

KW - HIV-2/drug effects

KW - Humans

KW - Internationality

KW - Male

KW - Middle Aged

KW - RNA, Viral/blood

KW - Viral Load

UR - https://www.scopus.com/pages/publications/85028557471

U2 - 10.1093/jac/dkx210

DO - 10.1093/jac/dkx210

M3 - Article

C2 - 29091198

AN - SCOPUS:85028557471

SN - 0305-7453

VL - 72

SP - 2869

EP - 2878

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 10

ER -

CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: A multinational, multicohort European study

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Keywords

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