TY - GEN
T1 - Cavitation-enhanced back projection for acoustic detection of attenuating structures
AU - Ramaekers, Pascal
AU - De Greef, Martijn
AU - Moonen, Chrit T.W.
AU - Ries, Mario
N1 - Funding Information:
The authors would like to thank Joost Wijlemans MD and the Communal Animal Laboratory Utrecht for their support regarding the in vivo animal experiment. Additionally, many thanks go to Dr Gerald Schubert of Philips Healthcare for his allround support regarding the HIFU system. The research conducted in this work was made possible by the following grants: x European Research Council (ERC), project # ERC-2010-AdG 268906-Sound Pharma x VOLTA project, Center for Translational Molecular Medicine (CTMM), project # 05T-201 x iPaCT project, Seventh Framework Programme (FP7), Grant # 603028
Publisher Copyright:
© 2017 Author(s).
PY - 2017/3/17
Y1 - 2017/3/17
N2 - Current methodology for the detection of attenuating structures in abdominal HIFU interventions requires lengthy, elaborate image analysis, which is undesired in a clinical setting. In this work, a method for the acoustic detection of attenuating structures in the beam path of the therapeutic HIFU array is described. The proposed method is used to determine binary apodizations that can be applied to the HIFU transducer for intercostal shot positions. Such a binary apodization was determined in vivo on an anesthetized pig under controlled breathing. Validation of the proposed method was done by comparing the binary apodization based on the proposed method to a binary apodization obtained using methodology based on MR image analysis and a collision detection algorithm. The proposed acoustical method provided a binary apodization that was over 90% similar to the apodization obtained using the image analysis-based method. Additionally, the proposed method can provide a measure of the amount of attenuation that each respective transducer element encounters in its beam path towards the focus.
AB - Current methodology for the detection of attenuating structures in abdominal HIFU interventions requires lengthy, elaborate image analysis, which is undesired in a clinical setting. In this work, a method for the acoustic detection of attenuating structures in the beam path of the therapeutic HIFU array is described. The proposed method is used to determine binary apodizations that can be applied to the HIFU transducer for intercostal shot positions. Such a binary apodization was determined in vivo on an anesthetized pig under controlled breathing. Validation of the proposed method was done by comparing the binary apodization based on the proposed method to a binary apodization obtained using methodology based on MR image analysis and a collision detection algorithm. The proposed acoustical method provided a binary apodization that was over 90% similar to the apodization obtained using the image analysis-based method. Additionally, the proposed method can provide a measure of the amount of attenuation that each respective transducer element encounters in its beam path towards the focus.
UR - http://www.scopus.com/inward/record.url?scp=85028922402&partnerID=8YFLogxK
U2 - 10.1063/1.4977633
DO - 10.1063/1.4977633
M3 - Conference contribution
AN - SCOPUS:85028922402
VL - 1821
BT - Proceedings from the 14th International Symposium on Therapeutic Ultrasound, ISTU 2014
PB - American Institute of Physics Inc.
T2 - 14th International Symposium on Therapeutic Ultrasound, ISTU 2014
Y2 - 2 April 2014 through 5 April 2014
ER -