Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study

A. Lalmohamed; M. T. Bazelier; T. P. Van Staa; B. M. J. Uitdehaag; H. G. M. Leufkens; A. De Boer; F. De Vries

doi:10.1111/j.1468-1331.2012.03668.x

Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study

A. Lalmohamed, M. T. Bazelier, T. P. Van Staa, B. M. J. Uitdehaag, H. G. M. Leufkens, A. De Boer, F. De Vries^*

^*Corresponding author for this work

Clinical Pharmacy

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and purpose: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. Methods: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). Results: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.634.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.1610.87) (but not in ex-smokers) and subjects with a body mass index of

Original language	English
Pages (from-to)	1007-1014
Number of pages	8
Journal	European Journal of Neurology
Volume	19
Issue number	7
DOIs	https://doi.org/10.1111/j.1468-1331.2012.03668.x
Publication status	Published - Jul 2012

Keywords

cause of death
mortality
mortality effect modifiers
multiple sclerosis
PRACTICE RESEARCH DATABASE
DANISH PATIENTS
US VETERANS
FOLLOW-UP
SURVIVAL
MORTALITY
SMOKING
RISK

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10.1111/j.1468-1331.2012.03668.x

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@article{72b8a2f4dc694d908b4579e6514b3c2c,

title = "Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study",

abstract = "Background and purpose: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. Methods: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). Results: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.634.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.1610.87) (but not in ex-smokers) and subjects with a body mass index of",

keywords = "cause of death, mortality, mortality effect modifiers, multiple sclerosis, PRACTICE RESEARCH DATABASE, DANISH PATIENTS, US VETERANS, FOLLOW-UP, SURVIVAL, MORTALITY, SMOKING, RISK",

author = "A. Lalmohamed and Bazelier, {M. T.} and {Van Staa}, {T. P.} and Uitdehaag, {B. M. J.} and Leufkens, {H. G. M.} and {De Boer}, A. and {De Vries}, F.",

year = "2012",

month = jul,

doi = "10.1111/j.1468-1331.2012.03668.x",

language = "English",

volume = "19",

pages = "1007--1014",

journal = "European Journal of Neurology",

issn = "1351-5101",

publisher = "Wiley-Blackwell",

number = "7",

}

TY - JOUR

T1 - Causes of death in patients with multiple sclerosis and matched referent subjects

T2 - a population-based cohort study

AU - Lalmohamed, A.

AU - Bazelier, M. T.

AU - Van Staa, T. P.

AU - Uitdehaag, B. M. J.

AU - Leufkens, H. G. M.

AU - De Boer, A.

AU - De Vries, F.

PY - 2012/7

Y1 - 2012/7

N2 - Background and purpose: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. Methods: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). Results: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.634.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.1610.87) (but not in ex-smokers) and subjects with a body mass index of

AB - Background and purpose: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. Methods: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). Results: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.634.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.1610.87) (but not in ex-smokers) and subjects with a body mass index of

KW - cause of death

KW - mortality

KW - mortality effect modifiers

KW - multiple sclerosis

KW - PRACTICE RESEARCH DATABASE

KW - DANISH PATIENTS

KW - US VETERANS

KW - FOLLOW-UP

KW - SURVIVAL

KW - MORTALITY

KW - SMOKING

KW - RISK

U2 - 10.1111/j.1468-1331.2012.03668.x

DO - 10.1111/j.1468-1331.2012.03668.x

M3 - Article

C2 - 22353360

SN - 1351-5101

VL - 19

SP - 1007

EP - 1014

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 7

ER -

Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study

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Keywords

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