TY - JOUR
T1 - Catching the Culprit
T2 - Benzylpenicillin Neurotoxicity Confirmed by Therapeutic Drug Monitoring in a Critically Ill Patient With Continuous Venovenous Hemofiltration
AU - van Gelder, Thomas G
AU - Schweitzer, Valentijn A
AU - Uijtendaal, Esther V
AU - Sikma, Maaike A
N1 - Publisher Copyright:
© 2024 The Author(s).
PY - 2024/8/1
Y1 - 2024/8/1
N2 - We present the case of a 65-year-old patient who was treated with high-dose benzylpenicillin for severe invasive pneumococcal pneumonia, complicated by acute renal failure managed with continuous venovenous hemofiltration. After cessation of continuous venovenous hemofiltration, the patient experienced multiple tonic-clonic seizures. Therapeutic drug monitoring revealed high total serum concentrations of benzylpenicillin, identifying it as the likely cause of the neurotoxicity. This case study presents the first documented total serum benzylpenicillin concentration associated with neurotoxicity.
AB - We present the case of a 65-year-old patient who was treated with high-dose benzylpenicillin for severe invasive pneumococcal pneumonia, complicated by acute renal failure managed with continuous venovenous hemofiltration. After cessation of continuous venovenous hemofiltration, the patient experienced multiple tonic-clonic seizures. Therapeutic drug monitoring revealed high total serum concentrations of benzylpenicillin, identifying it as the likely cause of the neurotoxicity. This case study presents the first documented total serum benzylpenicillin concentration associated with neurotoxicity.
KW - CRRT
KW - benzylpenicillin
KW - intensive care unit
KW - neurotoxicity
KW - therapeutic drug monitoring
UR - http://www.scopus.com/inward/record.url?scp=85198677194&partnerID=8YFLogxK
U2 - 10.1097/FTD.0000000000001215
DO - 10.1097/FTD.0000000000001215
M3 - Article
C2 - 38840334
SN - 0163-4356
VL - 46
SP - 556
EP - 558
JO - Therapeutic drug monitoring
JF - Therapeutic drug monitoring
IS - 4
ER -