TY - JOUR
T1 - Cardiovascular Health at Age 5 Years
T2 - Distribution, Determinants, and Association With Neurodevelopment
AU - Climie, Rachel E
AU - Tafflet, Muriel
AU - van Sloten, Thomas
AU - de Lauzon-Guillain, Blandine
AU - Bernard, Jonathan Y
AU - Dargent-Molina, Patricia
AU - Plancoulaine, Sabine
AU - Lioret, Sandrine
AU - Jouven, Xavier
AU - Charles, Marie-Alines
AU - Heude, Barbara
AU - Empana, Jean-Philippe
N1 - Funding Information:
The EDEN study was supported by the Foundation for Medical Research (FRM), National Agency for Research (ANR), National Institute for Research in Public Health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programs (FP7/2007–2013, HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program [through a collaboration with the French Association of Diabetic Patients (AFD)], French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l'Education Nationale a Complementary Health Insurance (MGEN), French National Agency for Food Security, and the French-Speaking Association for the Study of Diabetes and Metabolism (ALFEDIAM). This project was supported by funding from the European Union's Horizon 2020 research and innovation program under grant agreement 874739 (LongITools). RC was supported by a Postdoctoral Fellowship from the National Heart Foundation of Australia (Award ID: 102484). J-PE received support from the non-profit Fondation Française de Cardiologie to run this project.
Publisher Copyright:
Copyright © 2022 Climie, Tafflet, Sloten, Lauzon-Guillain, Bernard, Dargent-Molina, Plancoulaine, Lioret, Jouven, Charles, Heude and Empana.
PY - 2022/4/11
Y1 - 2022/4/11
N2 - Background: Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and to compare the level of cognitive development between children with and without ideal CVH at age 5 years. Methods: Using data from the Etude sur les déterminants pré et post natals précoces du Développement psychomoteur et de la santé de l'Enfant (EDEN) study, a French population-based mother–child cohort study, CVH was examined in children at 5 years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels, and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (five to six ideal metrics) or non-ideal CVH (<5 ideal metrics). Intelligence quotient (IQ) at age 5 years was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence. Results: Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR = 1.77, 95% CI 1.13–2.78), children with intermediate (1.77, 1.05–2.98) or ideal (2.58, 1.38–4.82) behavioral CVH at age 3 years and children who spent < 30 min/day watching television (1.91, 1.09–3.34) at age 3 years were more likely to have ideal CVH at age 5 years. At age 5 years, there was a significant 2.98-point difference (95% CI 0.64–5.32) in IQ between children with and without ideal biological CVH after adjusting for confounders. Conclusion: This study highlights that only a third of children aged 5 years had ideal CVH and identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.
AB - Background: Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and to compare the level of cognitive development between children with and without ideal CVH at age 5 years. Methods: Using data from the Etude sur les déterminants pré et post natals précoces du Développement psychomoteur et de la santé de l'Enfant (EDEN) study, a French population-based mother–child cohort study, CVH was examined in children at 5 years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels, and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (five to six ideal metrics) or non-ideal CVH (<5 ideal metrics). Intelligence quotient (IQ) at age 5 years was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence. Results: Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR = 1.77, 95% CI 1.13–2.78), children with intermediate (1.77, 1.05–2.98) or ideal (2.58, 1.38–4.82) behavioral CVH at age 3 years and children who spent < 30 min/day watching television (1.91, 1.09–3.34) at age 3 years were more likely to have ideal CVH at age 5 years. At age 5 years, there was a significant 2.98-point difference (95% CI 0.64–5.32) in IQ between children with and without ideal biological CVH after adjusting for confounders. Conclusion: This study highlights that only a third of children aged 5 years had ideal CVH and identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.
KW - cardiovascular disease
KW - childhood
KW - determinants
KW - neurodevelopment
KW - primordial prevention
UR - http://www.scopus.com/inward/record.url?scp=85127747211&partnerID=8YFLogxK
U2 - 10.3389/fped.2022.827525
DO - 10.3389/fped.2022.827525
M3 - Article
C2 - 35479759
SN - 2296-2360
VL - 10
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 827525
ER -