TY - JOUR
T1 - Cardiovascular disease in the elderly
T2 - proceedings of the European Society of Cardiology - Cardiovascular Round Table
AU - Lettino, Maddalena
AU - Mascherbauer, Julia
AU - Nordaby, Matias
AU - Ziegler, André
AU - Collet, Jean Philippe
AU - Derumeaux, Geneviève
AU - Hohnloser, Stefan H.
AU - Leclercq, Christophe
AU - O'neill, Deirdre E.
AU - Visseren, Frank
AU - Weidinger, Franz
AU - Richard-Lordereau, Isabelle
N1 - Funding Information:
M.N.: employment with Boehringer Ingelheim International J.-P.C.: Grants or contracts from Bristol-Myers Squibb, Medtronic, and Pfizer; and honoraria from Abbott, AstraZeneca, Boston Scientific, and Sanofi. G.D.: institutional grants to INSERM (RHU CARMMA) from Agence Nationale pour la Recherche (ANR). S.H.H.: consulting fees from Bristol-Meyers Squibb, Pfizer, Boehringer Ingelheim, Bayer, and Daiichi Sankyo; and honoraria from Bristol-Meyers Squibb, Pfizer, Boehringer Ingelheim, Bayer, and Daiichi Sankyo. D.E.O.: honoraria from Servier Canada. F.V.: research funding from Amgen. I.R.-L.: employment with and stock options from Amgen. And all other authors have no conflict of interest to declare.
Publisher Copyright:
© 2022 Published on behalf of the European Society of Cardiology.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - The growing elderly population worldwide represents a major challenge for caregivers, healthcare providers, and society. Older patients have a higher prevalence of cardiovascular (CV) disease, high rates of CV risk factors, and multiple age-related comorbidities. Although prevention and management strategies have been shown to be effective in older people, they continue to be under-used, and under-studied. In addition to hard endpoints, frailty, cognitive impairments, and patients' re-assessment of important outcomes (e.g. quality of life vs. longevity) are important aspects for older patients and emphasize the need to include a substantial proportion of older patients in CV clinical trials. To complement the often skewed age distribution in clinical trials, greater emphasis should be placed on real-world studies to assess longer-term outcomes, especially safety and quality of life outcomes. In the complex environment of the older patient, a multidisciplinary care team approach with the involvement of the individual patient in the decision-making process can help optimize prevention and management strategies. This article aims to demonstrate the growing burden of ageing in real life and illustrates the need to continue primary prevention to address CV risk factors. It summarizes factors to consider when choosing pharmacological and interventional treatments for the elderly and the need to consider quality of life and patient priorities when making decisions.
AB - The growing elderly population worldwide represents a major challenge for caregivers, healthcare providers, and society. Older patients have a higher prevalence of cardiovascular (CV) disease, high rates of CV risk factors, and multiple age-related comorbidities. Although prevention and management strategies have been shown to be effective in older people, they continue to be under-used, and under-studied. In addition to hard endpoints, frailty, cognitive impairments, and patients' re-assessment of important outcomes (e.g. quality of life vs. longevity) are important aspects for older patients and emphasize the need to include a substantial proportion of older patients in CV clinical trials. To complement the often skewed age distribution in clinical trials, greater emphasis should be placed on real-world studies to assess longer-term outcomes, especially safety and quality of life outcomes. In the complex environment of the older patient, a multidisciplinary care team approach with the involvement of the individual patient in the decision-making process can help optimize prevention and management strategies. This article aims to demonstrate the growing burden of ageing in real life and illustrates the need to continue primary prevention to address CV risk factors. It summarizes factors to consider when choosing pharmacological and interventional treatments for the elderly and the need to consider quality of life and patient priorities when making decisions.
KW - Anticoagulant
KW - Antiplatelet
KW - Coronary revascularization
KW - Older people
KW - Primary prevention
KW - Risk assessment
UR - https://www.scopus.com/pages/publications/85135599435
U2 - 10.1093/eurjpc/zwac033
DO - 10.1093/eurjpc/zwac033
M3 - Review article
C2 - 35167666
SN - 2047-4873
VL - 29
SP - 1412
EP - 1424
JO - European journal of preventive cardiology
JF - European journal of preventive cardiology
IS - 10
ER -