Cardiovasculaire en gastro-intestinale veiligheid van NSAID's

Patricia M L A van den Bemt; Eric T T L Tjwa; Martijn G H van Oijen

Cardiovasculaire en gastro-intestinale veiligheid van NSAID's

Translated title of the contribution: Cardiovascular and gastrointestinal safety of NSAIDs

Patricia M L A van den Bemt
, Eric T T L Tjwa
, Martijn G H van Oijen

Research output: Contribution to journal › Review article › peer-review

Abstract

All NSAIDs may induce cardiotoxicity. In this respect naproxen is relatively the safest choice. Selective cyclo-oxygenase-2-inhibitors (coxibs) are at least as effective in preventing clinically relevant gastrointestinal toxicity as non-selective NSAIDs plus a protonpump inhibitor (PPI). Non-selective NSAIDs plus a PPI are more effective in prevention of dyspepsia than coxibs. After a serious gastrointestinal complication while using NSAIDs, in principal the patient should no longer use NSAIDs. If needed, a coxib plus a PPI is the first choice.

Translated title of the contribution	Cardiovascular and gastrointestinal safety of NSAIDs
Original language	Dutch
Pages (from-to)	A7311
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	158
Publication status	Published - 2014
Externally published	Yes

Keywords

Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Cardiovascular Diseases/chemically induced
Cyclooxygenase 2 Inhibitors/therapeutic use
Gastrointestinal Diseases/chemically induced
Humans
Naproxen
Proton Pump Inhibitors/therapeutic use

Cite this

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title = "Cardiovasculaire en gastro-intestinale veiligheid van NSAID's",

abstract = "All NSAIDs may induce cardiotoxicity. In this respect naproxen is relatively the safest choice. Selective cyclo-oxygenase-2-inhibitors (coxibs) are at least as effective in preventing clinically relevant gastrointestinal toxicity as non-selective NSAIDs plus a protonpump inhibitor (PPI). Non-selective NSAIDs plus a PPI are more effective in prevention of dyspepsia than coxibs. After a serious gastrointestinal complication while using NSAIDs, in principal the patient should no longer use NSAIDs. If needed, a coxib plus a PPI is the first choice.",

keywords = "Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Cardiovascular Diseases/chemically induced, Cyclooxygenase 2 Inhibitors/therapeutic use, Gastrointestinal Diseases/chemically induced, Humans, Naproxen, Proton Pump Inhibitors/therapeutic use",

author = "\{van den Bemt\}, \{Patricia M L A\} and Tjwa, \{Eric T T L\} and \{van Oijen\}, \{Martijn G H\}",

year = "2014",

language = "Dutch",

volume = "158",

pages = "A7311",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Vereniging Nederlands Tijdschrift voor Geneeskunde",

}

TY - JOUR

T1 - Cardiovasculaire en gastro-intestinale veiligheid van NSAID's

AU - van den Bemt, Patricia M L A

AU - Tjwa, Eric T T L

AU - van Oijen, Martijn G H

PY - 2014

Y1 - 2014

N2 - All NSAIDs may induce cardiotoxicity. In this respect naproxen is relatively the safest choice. Selective cyclo-oxygenase-2-inhibitors (coxibs) are at least as effective in preventing clinically relevant gastrointestinal toxicity as non-selective NSAIDs plus a protonpump inhibitor (PPI). Non-selective NSAIDs plus a PPI are more effective in prevention of dyspepsia than coxibs. After a serious gastrointestinal complication while using NSAIDs, in principal the patient should no longer use NSAIDs. If needed, a coxib plus a PPI is the first choice.

AB - All NSAIDs may induce cardiotoxicity. In this respect naproxen is relatively the safest choice. Selective cyclo-oxygenase-2-inhibitors (coxibs) are at least as effective in preventing clinically relevant gastrointestinal toxicity as non-selective NSAIDs plus a protonpump inhibitor (PPI). Non-selective NSAIDs plus a PPI are more effective in prevention of dyspepsia than coxibs. After a serious gastrointestinal complication while using NSAIDs, in principal the patient should no longer use NSAIDs. If needed, a coxib plus a PPI is the first choice.

KW - Anti-Inflammatory Agents, Non-Steroidal/adverse effects

KW - Cardiovascular Diseases/chemically induced

KW - Cyclooxygenase 2 Inhibitors/therapeutic use

KW - Gastrointestinal Diseases/chemically induced

KW - Humans

KW - Naproxen

KW - Proton Pump Inhibitors/therapeutic use

M3 - Review article

C2 - 24713339

SN - 0028-2162

VL - 158

SP - A7311

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

ER -

Cardiovasculaire en gastro-intestinale veiligheid van NSAID's

Abstract

Keywords

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